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Longer-term follow-up of users of estrogen therapy finds some changes in risks
Date:4/5/2011

group. Similarly, the increase in deep vein thrombosis and pulmonary embolism with CEE use compared with placebo during the intervention phase was not maintained during the postintervention phase.

The risk of invasive breast cancer in women randomized to CEE vs. placebo was similar during the intervention and postintervention phases. "Consequently, a statistically significant lower cumulative breast cancer incidence of 0.27 percent was seen in the CEE group (n = 151) compared with 0.35 percent in the placebo group (n=199). Colorectal cancer incidence did not differ between the women in the CEE group and the placebo group during the intervention or postintervention periods," the authors write.

They add that the reduced hip fracture risk seen during the intervention phase with CEE was not maintained in the postintervention phase, with hip fracture incidence slightly higher in the CEE group compared with the placebo group during the postintervention phase. Randomization to CEE did not influence total mortality during the intervention or postintervention phase. Health outcomes were more favorable for younger compared with older women for CHD, heart attack, colorectal cancer, total mortality, and a global index of chronic diseases .

"Our results emphasize the need to counsel women about hormone therapy differently depending on their age and hysterectomy status. A postmenopausal woman who has had a hysterectomy and is considering initiation of CEE should be counseled about the increased risks of venous thromboembolism and stroke during treatment, which diminish with treatment cessation. Among younger women, no new safety concerns emerged and some risk reductions became apparent during the postintervention period. Among older women, risks of colorectal cancer, death, and the global index of chronic diseases were elevated over the cumulative follow-up period. The risks and benefits of CEE use for periods of longer than 5 to 6 years cannot be infe
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Contact: Kristen Woodward
kwoodwar@fhcrc.org
206-667-5095
JAMA and Archives Journals
Source:Eurekalert

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