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Joan Massagué wins BBVA Foundation Frontiers of Knowledge Award in Biomedicine
Date:6/17/2009

tice. Massagu has this to say about the applied side of his work: "More than ever science permeates our everyday life. Biomedicine, at least, is a subject of great public interest and growing public understanding. Scientists respond to this demand by looking for faster ways to translate basic discoveries into practical knowledge with the power to solve health problems."

Hence the succinct phrase the scientist employs to express his research motivation: "To uncover the unknown for the service of mankind".

Massagu has over 340 publications to his name in leading scientific journals. He heads the Cancer Biology and Genetics Program at the Sloan-Kettering Institute, where he has pursued most of his scientific career. He is also a researcher at the Howard Hughes Medical Institute and adjunct director of the Institute for Biomedical Research (IRB Barcelona). His professional life, in other words, is a constant "shuttling between New York and Barcelona".

Among the milestones in his scientific career was the isolating of TGF- (transforming growth factor beta), a group of molecules segregated by tumor cells that make normal cells behave like cancer cells. We now know that TGF- is the principle inhibitor of cell growth. It is essential for the organism's normal development but, when disrupted, is also implicated in disease processes such as malformations and cancer. Massagu and his group identified the molecular pathway conveying the TGF- signal from the cell membrane to the nucleus rather like decoding the language it uses to communicate with other molecules and in this way have helped to elucidate one of the fundamental processes controlling cell division.

Award presentation ceremony

The presentation ceremony will take place on June 18 in the BBVA Foundation's Madrid headquarters under the presidency of the Minister of Science and Innovation, Cristina Garmendia, and the BBVA Foundation President, Francisco Gonzlez
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Contact: Javier Fernandez
comunicacion@fbbva.es
34-915-376-615
Fundacin BBVA
Source:Eurekalert

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