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JCI online early table of contents: Nov. 8, 2010
Date:11/8/2010

m diabetic mice improved their wound healing functionality. The authors therefore suggest that a similar gene therapy approach may be of benefit to patients with diabetes.

TITLE: Manganese superoxide dismutase expression in endothelial progenitor cells accelerates wound healing in diabetic mice

AUTHOR CONTACT:
Alex F. Chen
University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Phone: 412.624.6769; Fax: 412.648.7107; E-mail: chena5@upmc.edu.

View this article at: http://www.jci.org/articles/view/36858?key=a299074908118e6d4901

MUSCLE BIOLOGY: A complement to muscle wasting

Individuals with mutations in their dysferlin gene develop one of a group of muscle-wasting diseases sometimes referred to as dysferlinopathies. The exact mechanism(s) underlying the muscle wasting in these individuals is not completely understood. Now, a team of researchers, led by Kevin Campbell, at The University of Iowa, Iowa City, has identified a role for a component of the immune system that is involved in promoting inflammation (specifically, the complement system) in the muscle disease experienced by mice that lack dysferlin and thereby model dysferlinopathies. Among the several lines of evidence generated to support this conclusion was the observation that genetic manipulation of dysferlin-deficient mice such that the lacked the central complement protein C3 ameliorated the muscle wasting observed in dysferlin-deficient mice. These data lead the authors to suggest that targeting the complement system might provide a way to treat dysferlinopathies.

TITLE: Genetic ablation of complement C3 attenuates muscle pathology in dysferlin-deficient mice

AUTHOR CONTACT:
Kevin P. Campbel
Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa
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Journal of Clinical Investigation
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