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JCI online early table of contents: June 13, 2011
Date:6/13/2011

cure for PAH. However, recent advances in understanding the mechanisms underlying PAH have led to new, clinically beneficial therapeutic approaches. A team of researchers, led by Jean-Sbastien Hulot, at Universit Pierre et Marie Curie, France, has gained new insight into the mechanisms underlying PAH that leads them to suggest that inhibiting the protein MRP4 could provide a new way to treat individuals with PAH.

The initial analysis of Hulot and colleagues indicated that expression of MRP4 was markedly higher in lung samples from patients with clinical pulmonary hypertension than in those from healthy individuals. Consistent with a role for MRP4 in the development of PAH, mice lacking MRP4 were protected from pulmonary hypertension. Of clinical importance, treatment of normal mice with an inhibitor of MRP4 reversed pulmonary hypertension. These data provide the rationale for the authors' suggestion that MRP4 could be targeted for the treatment of PAH.

TITLE: Inhibition of MRP4 prevents and reverses pulmonary hypertension in mice

AUTHOR CONTACT:
Jean-Sbastien Hulot
Universit Pierre et Marie Curie, INSERM UMR956, Paris, France.
Phone: 33.1.40.77.95.84; Fax: 33.1.40.77.96.45; E-mail: jean-sebastien.hulot@psl.aphp.fr.

View this article at: http://www.jci.org/articles/view/45023?key=1fd07cf00b53be57277f

AGING: Growing old gracefully: premature aging condition provides clues about normal aging

A team of researchers, led by Francis Collins, at the National Institutes of Health, Bethesda, has now linked a mutant protein that is key to a devastating premature aging disease to the normal aging process.

Hutchinson-Gilford progeria syndrome (HGPS) is a genetic disease that dramatically accelerates the aging process; children with HGPS die at an average a
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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
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