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JCI online early table of contents: June 13, 2011
Date:6/13/2011

is article at: http://www.jci.org/articles/view/44489?key=4b09fd39d7a54a394fb1


ONCOLOGY: Small but powerful cancer probe

Nanoparticle-based materials are under development for many clinical uses; for example, they are being developed for use as drug-delivery vehicles and diagnostic probes. However, many such materials currently under evaluation in oncology clinical trials are not tumor selective. Now, a team of researchers, led by Michelle Bradbury, at the Sloan-Kettering Institute for Cancer Research, New York, has characterized an approximately 7-nm diameter multimodal silica nanoparticle that is tumor selective and nontoxic. Importantly, the team used these particles to image tumor spread in a spontaneous skin cancer miniswine model. The authors therefore suggest that their data highlight the potential of these cancer-selective silica nanoparticles for determining disease spread in the clinical setting, something that could become a reality sooner rather than later because the nanoparticles were recently approved for a first-in-human clinical trial.

TITLE: Multimodal silica nanoparticles are effective cancer-targeted probes in a model of human melanoma

AUTHOR CONTACT:
Michelle S. Bradbury
Sloan-Kettering Institute for Cancer Research, New York, New York, USA.
Phone: 212.639.8938; Fax: 212.794.4010; E-mail: bradburm@mskcc.org.

View this article at: http://www.jci.org/articles/view/45600?key=30564f662e8f215b7d0a


PULMONARY: New way to treat pulmonary hypertension?

Pulmonary arterial hypertension (PAH) is a severe disease of the arterial blood vessels in the lungs that leads to progressive failure of the right side of the heart and premature death. There is no
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Journal of Clinical Investigation
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