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JCI online early table of contents: July 18, 2011
Date:7/18/2011

LOGY: Understanding the formation of valves in veins

Most veins have one-way flaps called venous valves that ensure that blood flows in one direction. Dysfunction of venous valves leads to serious clinical conditions, including leg swelling and chronic ulceration. Despite this, little is known about the molecular mechanisms regulating the formation and maintenance of venous valves. However, a team of researchers, led by Taija Makinen, at the Cancer Research UK London Research Institute, United Kingdom, has now identified in mice several signaling pathways regulating venous valve formation. Of particular interest, the cells lining venous valves were found to closely resemble the cells lining valves in lymphatic vessels at the molecular level, suggesting plasticity in the ability of a valve-lining cell to take on a different identity.

TITLE: Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice

AUTHOR CONTACT:
Taija Makinen
Cancer Research UK London Research Institute, London, United Kingdom.
Phone: 44.207.269.3459; Fax: 44.207.269.3147; E-mail: taija.makinen@cancer.org.uk.

View this article at: http://www.jci.org/articles/view/58050?key=7f740e9a8a6a8a3437a1

MUSCLE BIOLOGY: Endurance protein IL-15R-alpha

The protein IL-15R-alpha is perhaps best known as a component of the protein to which the immune-modulating factor IL-15 binds to mediates its effects. However, recent studies have indicated that this is not the only function of IL-15R-alpha, as some of the characteristics of mice lacking IL-15R-alpha differ from those lacking IL-15. In this context, a team of researchers, led by Tejvir S. Khurana, at the University of Pennsylvania School of Medicine, Philadelphia, has now defined a unique role for IL-15R-alpha in
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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
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