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JCI online early table of contents: July 18, 2011
Date:7/18/2011

EDITOR'S PICK: IDOLizing low cholesterol

High levels of 'bad' cholesterol (LDL cholesterol) are a risk factor for developing atherosclerotic cardiovascular disease (ASCVD) a disease of the major arterial blood vessels that is one of the major causes of heart attack and stroke. Although the use of statins and the adoption of lifestyle changes to reduce LDL cholesterol levels have decreased the incidence of and mortality from ASCVD, many individuals fail to reach target levels of LDL cholesterol. Researchers are therefore seeking new targets for LDL cholesterollowering therapeutics. Human genetic and mechanistic studies by a team of researchers, led by Pivi Pajukanta, at the David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, has now identified the protein MYLIP (also known as IDOL) as a potential new target in this context.

TITLE: The N342S MYLIP polymorphism is associated with high total cholesterol and increased LDL receptor degradation in humans

AUTHOR CONTACT:
Pivi Pajukanta
David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Phone: 310.267.2011; Fax: 310.794.5446; E-mail: ppajukanta@mednet.ucla.edu.

View this article at: http://www.jci.org/articles/view/45504?key=d5edfd2925fed609d5f4

ONCOLOGY: Platinum-based drugs: double trouble for tumors

One of the reasons that tumors are able to grow rapidly is that they actively prevent immune cells from generating effective antitumor immune responses. Researchers are developing approaches to combat the mechanisms used by tumors to inhibit immune responses, but such approaches don't kill tumor cells directly. A team of researchers, led by Jolanda de Vries and Joost Lesterhuis, at Radboud University Nijmegen Medical Centre, Netherlands, has ide
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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
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