Inflammation may trigger Alzheimer's disease, Saint Louis University findin...(foreign substances. We induced inf...),Health

"We induced inflammation in mice and found that it turned off the LRP pump that lets amyloid beta protein exit the brain into the bloodstream. It also revved up an entrance pump that transports amyloid beta into the brain. Both of these actions would increase the amount of amyloid beta protein in the brain."

Banks then gave mice indomethacin, which prevented inflammation from turning off the LRP (exit pump).

His findings help to explain what doctors who are studying the use of indomethacin to treat people with Alzheimer's disease are seeing in their clinical practice.

"Nonsteroidal anti-inflammatory drugs, especially indomethacin, have been associated with protection against Alzheimer's disease. Our work could influence that debate and thinking at the patient-care level," Banks said.

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