Navigation Links
Increased arm swing asymmetry is early sign of Parkinson's disease
Date:12/13/2011

People with Parkinson's disease swing their arms asymmetrically -- one arm swings less than the other -- when walking. This unusual movement is easily detected early when drugs and other interventions may help slow the disease, according to Penn State researchers who used inexpensive accelerometers on the arms of Parkinson's disease patients to measure arm swing.

"Scientists have known for some time that people with Parkinson's disease exhibit reduced arm swing during the later stages of the disease, but no one had come up with an easy way to measure this," said Stephen Piazza, associate professor of kinesiology. "We found that not only do people with the disease exhibit reduced arm swing, but they also exhibit asymmetric arm swing, and this asymmetric arm swing can easily be detected early in the disease's progression."

No cure for Parkinson's disease exists, but according to Piazza, if taken early, certain drugs can improve some of the disease's symptoms and even reduce the likelihood of death, making early diagnosis important. Some people also believe that changes in nutrition and other lifestyle factors can modify the progression of the disease.

The researchers attached inexpensive accelerometers to the arms of eight Parkinson's disease patients who were in the early stages of the disease -- within three years of clinical diagnosis. They also attached the accelerometers to the arms of eight age- and sex-matched people who did not have the disease. The team asked the subjects to walk continuously for about eight minutes at a comfortable pace. The researchers downloaded the acceleration data and used software they developed -- that will be available free to interested doctors -- to analyze it. They published their results in the current issue of Gait & Posture.

The scientists found significantly higher acceleration asymmetry, lower cross-correlation between the arms and reduced synchronization of the arms in the early Parkinson's disease patients. According to Joseph Cusumano, professor of engineering science and mechanics, the lower cross-correlation and reduced synchronization suggest that the arm movements are poorly coordinated.

"In other words, if I measure the location of your right arm, it is difficult to use that measurement to predict the location of your left arm," he said. "It is well known that Parkinson's disease has an impact on how people move -- neurologists have been using this fact as the basis for clinical examinations for a very, very long time -- but here we are for the first time precisely quantifying how the disease not only affects the relative amount of limb movements, but also how well coordinated in time these movements are."

To diagnose patients with Parkinson's disease early, some doctors and scientists have proposed the use of a smell test, because people with the disease lose their ability to distinguish odors, according to Xuemei Huang, movement disorders physician, Penn State Milton S. Hershey Medical Center. "But conditions other than Parkinson's disease also can affect a person's ability to smell," she said.

The Penn State team's method of evaluating arm swing can be applied quickly and inexpensively by primary care physicians in their own offices when the smell test is inconclusive and before the application of an expensive brain scan.

"Measuring arm swing asymmetry and coordination with our method may be the cheapest and most effective way to detect Parkinson's disease early in patients' lives when it still is possible to treat the symptoms of the disease and to improve longevity," said Piazza.

The scientists plan to further investigate whether the arm swing evaluation in combination with a smell test can enhance early diagnosis even more. They also plan to further develop their technique so that the accelerometers give immediate readings, which, they said, would save the extra step of downloading the data to a computer and analyzing it, thereby making the arm swing assessments of Parkinson's disease even easier.

Penn State graduate students Joseph Mahoney, Mechelle Lewis and Guangwei Du also worked on this project.


'/>"/>

Contact: A'ndrea Elyse Messer
aem1@psu.edu
814-865-9481
Penn State
Source:Eurekalert

Related medicine news :

1. Migraine Linked to Increased Heart Attack Risk
2. Attorney Joe Belluck Hails Department Of Defense For Increased Funding Of Mesothelioma Research
3. Increased HAART coverage associated with 50 percent drop
4. RetireSafe Survey Says Seniors Are Struggling With Increased Costs Without an Increased Social Security Cost of Living Adjustment
5. Arsenic exposure activates an oncogenic signaling pathway; leads to increased cancer risk
6. Increased Government Scrutiny of Companies That Use Independent Contractors, Consultants, or Freelancers: Are You Ready? Learn More at Complimentary Breakfast Briefing
7. Hormone thought to slow aging associated with increased risk of cancer death
8. Hormone replacement therapy linked to increased lung cancer risk
9. NACDS RxIMPACT "Hill Day" Features More Advocates Increased Focus on Medication Adherence
10. Weight-bearing exercise does not prevent increased bone turnover during weight loss
11. Increased radiation dose does not increase long-term side effects for prostate cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/9/2016)... ... ... Cellairis is a worldwide mobile device and computer repair franchise that is known ... Samsung Galaxy devices with premium parts and accessories. Cellairis has recently set-up for business ... customers. While customers do their shopping, Cellairis can accomplish a number of mobile device ...
(Date:12/9/2016)... ... December 09, 2016 , ... An inventor from Cana, ... safely ride all types of amusement park rides. , The patent-pending SAFETY STRAP FOR ... easy to use and could be set up in a matter of minutes, or ...
(Date:12/9/2016)... Harrisburg, PA (PRWEB) , ... December 09, 2016 ... ... concussion education program through the Pennsylvania Cable Network (PCN) during the summer of ... Brain Injury Implementation Grant provided by the United States Department of Health and ...
(Date:12/8/2016)... ... 2016 , ... ZyDoc , a New York-based medical ... Capture Methods for Input to Electronic Health Records: A Comparative Usability Study” has ... usability study demonstrate that a dictation-based method (“NLP Entry”) using ZyDoc’s MediSapien™ natural ...
(Date:12/8/2016)... Boston (PRWEB) , ... December 08, 2016 , ... ... shareholders with global law firm Greenberg Traurig, LLP, will speak at DeviceTalks West, Dec. ... sponsor of the DeviceTalks series, and attorneys from the firm’s global Life Sciences & ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)...  Eli Lilly and Company (NYSE: LLY ... EXPEDITION3 trial at the 9 th Clinical Trials ... did not meet the primary endpoint in the EXPEDITION3 ... with mild dementia due to Alzheimer,s disease (AD), and ... the treatment of mild dementia due to AD. ...
(Date:12/8/2016)... QUEBEC CITY , Dec. 8, 2016 /PRNewswire/ ... key US patents for improving the accuracy, reproducibility ... CD images in long and small bone orthopaedic ... proprietary approach to creating personalized orthopaedic restorations based ... create personalized orthopaedic restorations, the company harnesses the ...
(Date:12/8/2016)... , Dec. 8, 2016  EIP Pharma, ... has obtained proof-of-mechanism for neflamapimod (previously code named ... Phase 2a clinical trials that demonstrated significant Alzheimer,s ... 302 (12-week treatment) and Study 303 (6-week treatment) ... Trials in Alzheimer,s Disease (CTAD) scientific conference in ...
Breaking Medicine Technology: