Navigation Links
iNOS expression may links chronic biliary inflammation to malignant transformation
Date:12/19/2007

It is well known that chronic biliary inflammation is a risk factor for biliary carcinogenesis. However, the molecular mechanisms of biliary carcinogenesis as a consequence of chronic biliary inflammation remain unclear.

Inducible nitric oxide synthase (iNOS) is induced in inflamed tissues and generates large amounts of nitric oxide (NO) that can promote mutagenic changes in DNA through DNA oxidization and protein nitrosylation.

In a research article to be published on December 21 in the World Journal of Gastroenterology, Dr. Kitasato and colleagues investigated the role of iNOS activation, NO generation, and DNA damage as the link between chronic inflammation and biliary carcinogenesis, utilizing normal hamster gallbladder epithelial cells cultured in the presence of inflammatory cytokines.

NO generation was increased significantly following cytokine stimulation. Furthermore, the production of NO in the presence of inflammatory cytokines was completely suppressed by the addition of an iNOS inhibitor. The expression of iNOS mRNA in the gallbladder epithelial cells was clearly demonstrated in the presence of cytokine-stimulation, compared with that in the absence of stimulatory cytokines. Moreover, NO-dependent DNA damage was increased significantly by cytokines, and decreased to control levels by an iNOS inhibitor.

In this study, the researchers used primary epithelial cells isolated from hamster gallbladders. These normal epithelial cells are suitable for estimating the involvement of iNOS and NO in biliary carcinogenesis, especially in the initiation of biliary carcinoma as a response to chronic inflammation.

In normal hamster gallbladder epithelial cells, cytokine stimulation induced iNOS expression and NO generation, which was sufficient to cause DNA damage. The results of this study suggest that NO-mediated genotoxicity induced by inflammatory cytokines through activation of iNOS is involved in the process of biliary carcinogenesis in response to chronic inflammation of the biliary tree. These findings represent a new link between infection and carcinogenesis that may be applied broadly beyond the biliary tract.


'/>"/>

Contact: Jing Zhu
j.zhu@wjgnet.com
0086-108-538-1892
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. Altered expression of ultraconserved noncoding RNAs linked to human leukemias and carcinomas
2. 10th Anniversary of Revolutionary Teaching Approach that Offers the Severely Disabled the Gift of Self-Expression - Through Painting
3. New study shows that therapeutic gene expression can be sustainable for 1 year
4. Xceed Molecular Launches Ziplex(R) Automated Gene-Expression System at the Association for Molecular Pathology, Booth 84/85
5. Flip-flopping gene expression can be advantageous
6. Facial expressions have greater impact on kids with bipolar disorder
7. Biolytix to Offer Industrial Gene Expression Analysis and Genotyping Services Using Affymetrix GeneChip(R) Technology
8. Pathway links inflammation, angiogenesis and breast cancer
9. Research Links TV/Video Game Playing With Child Obesity; Health Experts Back a New Approach
10. Study links education to risk of cancer death
11. Study Links Coronary Disease, Colon Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2017)... ... ... The Industrial Designers Society of America (IDSA) hosted the ... Aug. 19, 2017 in Atlanta, GA—revealing which 25 designs won Gold and which 52 ... See all the winners at http://www.idsa.org/awards/idea/gallery . , “I hope you’re as excited ...
(Date:8/20/2017)... ... August 20, 2017 , ... State Farm Neighborhood Assist® has named The ... a $25,000 grant. If the initiative wins, Gals Lead – Dream Queen Foundation’s signature ... Tri-County area of St. Mary’s, Calvert and Charles Counties. The program could potentially impact ...
(Date:8/19/2017)... ... 18, 2017 , ... Western University of Health Sciences will host a special ... new Center for Innovation on Wednesday, September 6, 2017. , The symposium will be ... by a technology exhibition from 1 to 3 p.m. showcasing virtual reality education technology, ...
(Date:8/19/2017)... New York, New York (PRWEB) , ... August ... ... Fruit Street Health has announced that it is the first organization with pending ... the CDC’s National Diabetes Prevention Program (“DPP”) via group telehealth classes and live ...
(Date:8/19/2017)... ... , ... Yesterday, the President of the United States retracted his condemnation of ... not two sides to hatred, bigotry, discrimination, and a white supremacy nationalist agenda. ... against all forms of such hatred and discrimination in this country and globally. ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... Aug. 7, 2017 Zimmer Biomet Holdings, Inc. (NYSE ... announced that its Board of Directors has approved the payment ... quarter of 2017. The ... or about October 27, 2017 to stockholders of record as ... declarations of dividends are subject to approval of the Board ...
(Date:8/4/2017)... , Aug. 4, 2017 The search ... shortly after a physician/patient consult has long been the ... was a notable focus of the largest meeting of ... according to healthcare market research firm Kalorama Information.  The ... testing (POCT) offerings or related supplies and software were ...
(Date:8/2/2017)... BENTON, Ky. , Aug. 2, 2017   Marshall County Hospital in ... (ES) team to proactively reduce the risk of hospital-acquired infections (HAIs). The new addition, ... uses UVC light energy to kill deadly pathogens such as C. diff , MRSA, ... Tru-D SmartUVC ... Tru-D in action in a patient room ...
Breaking Medicine Technology: