Navigation Links
iCardiac's Highly Automated QT(sm) Technology Now Validated in Over 10 Clinical QT Studies
Date:2/5/2009

Validation Study Affirms Highly Automated Cardiac Safety ECG Analysis for Global Leader in Drug Development

Rochester, New York (PRWEB) February 5, 2009 -- iCardiac Technologies, Inc., a leading innovator in advanced cardiac safety biomakers and automated QT analysis, today announced the successful completion of a study for one of the world's leading pharmaceutical companies. The study validated the use of its Highly Automated QT(sm) technology to measure a full spectrum of ECG-based cardiac safety study data from mild to pronounced QT prolongation.

The study, performed with data from an existing compound, compared results from iCardiac's Highly Automated QT analysis with measurements performed independently by a large ECG core laboratory. The analysis was performed on data that included patients who ingested a placebo, moxifloxin (used as a positive control in cardiac safety studies), a normal and a supra-therapeutic dose of a study drug.

"This represents one of several validation studies of our technology with industry-leading drug developers," said iCardiac's Co-Founder and Executive Vice President Sasha Latypova. "To date our Highly Automated QT technology has been applied in over 10 clinical QT data analyses. Pharmaceutical companies are gaining more accurate results and are lowering substantially the cost per TQT study."

The study is part of iCardiac's broader validation program that aims at both reducing the cost of cardiac safety studies and developing the next generation of ECG biomarkers that are more predictive than the QT interval for characterizing arrhythmia risk associated with novel medicines.

The drive to automate more of the cardiac safety analysis process stems from general dissatisfaction in the industry regarding "gold standard" manual measurements that are both time-consuming and expensive. iCardiac's Highly Automated QT technology is different from "fully automated" approaches - which are based solely on computers - because it combines advanced ECG signal processing algorithms, developed over the past decade, with a robust quality assurance process conducted by cardiologists.

The technology performs a precise automated QT measurement and, using sophisticated statistical models and algorithms, guides cardiologists to those ECGs that require attention. It produces significant cost savings because only a portion of the entire Thorough QT (TQT) dataset requires manual over-reading.

Highly Automated QT analysis is part of iCardiac's software platform COMPAS 3.0, originally developed at the University of Rochester Heart Research Follow-Up Program, the international leader in electrophysiology research and the study of the congenital Long QT Syndrome. The platform provides comprehensive analysis of cardiac repolarization signals and contains several advanced arrhythmia biomarkers, as well as advanced ECG signal processing tools. The COMPAS platform serves as the core technology behind the leading cardiac safety analysis services that iCardiac provides to pharmaceutical, biotech companies and clinical research organizations.

About iCardiac Technologies
iCardiac Technologies, Inc. develops and implements advanced ECG-based cardiac safety biomarkers and tools. iCardiac's advanced ECG-based cardiac safety analysis service stems from more than 30 years of research at the University of Rochester, a leading institution for ventricular arrhythmias and cardiac repolarization. iCardiac's analysis service provides drug developers with more precise and cost-effective methods for QT interval measurement. In addition, it provides Beyond QT(sm), a suite of advanced ECG-based cardiac safety markers that deliver a more accurate assessment the cardiac safety profile of drugs in development. For more information, visit: www.icardiac.com.

###

Read the full story at http://www.prweb.com/releases/2009/02/prweb1957024.htm.


'/>"/>
Source: PRWeb
Copyright©2009 Vocus, Inc.
All rights reserved

Related medicine news :

1. Consumer Specialty Products Association Highly Critical of NRDC Study on Home Air Fresheners
2. 454 Sequencing(TM): Science Paper Describes a Novel, Highly Efficient Method of Sequencing Ancient DNA; Sequences the Mitochondria of 10 Individual Mammoths to Prove It
3. 18F-DG PET/CT can highly increase the detection of colorectal cancer
4. Plastic Surgery Complications and Deaths are Rare, Despite Highly Publicized Death of Donda West
5. CT angiography highly accurate, multicenter trials show
6. CT Angiography Highly Accurate: Multicenter Trials Show
7. SGX Pharmaceuticals Submits Investigational New Drug Application for SGX523, a Highly Potent, Selective, Orally Bioavailable cMET Inhibitor
8. Highly Promising Dutch Research Into Alzheimers Disease and Parkinsons Disease
9. Songbirds offer clues to highly practiced motor skills in humans
10. LASIK works well, according to long-term study of highly myopic patients
11. Researchers find less invasive, highly accurate methods
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... Toronto, Ontario (PRWEB) , ... February 05, 2016 , ... ... the Scarborough General Hospital Burn Unit, plastic and cosmetic surgeon Dr. Wayne Carman transitioned ... the Scarborough Hospital. He successfully completed his first three-year term as chief and began ...
(Date:2/5/2016)... ... 2016 , ... In the fourth quarter of 2015, document ... La Valencia Hotel in San Diego, California to discuss changes in the industry ... outstanding franchise, walking away with the coveted David Wright Award of Excellence. ...
(Date:2/5/2016)... Texas (PRWEB) , ... February 05, 2016 , ... ... to allow users to search for and donate to Give To Cure’s campaign that ... an app that lets users make and share payments through a smart device. In ...
(Date:2/5/2016)... New York, New York (PRWEB) , ... February 05, 2016 , ... ... (APDA) announced the election of Patrick McDermott as Chairman of the National Board of ... welcome Pat as Chairman of the Board,” stated Leslie A. Chambers , APDA ...
(Date:2/5/2016)... CA (PRWEB) , ... February 05, 2016 , ... ... and founder of CitiDent, announces that it is now welcoming orthodontist, Dr. ... Cheng, CitiDent offers a complete range of oral health care, including general dentistry, ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... 2016  Zimmer Biomet Holdings, Inc. (NYSE and SIX: ... underwritten secondary offering of 11,027,558 shares of its common ... of Blackstone and Goldman Sachs.  The shares are being ... $96.45 per share. The selling stockholders will receive all ... nor any of its directors, officers or other stockholders ...
(Date:2/5/2016)... Feb. 5, 2016 ... the "Global Obstetrics Partnering 2010-2016: Deal ... to their offering. --> http://www.researchandmarkets.com/research/hcdvg6/global_obstetrics ... "Global Obstetrics Partnering 2010-2016: Deal trends, ... their offering. --> Research and ...
(Date:2/4/2016)... , Feb. 4, 2016   Bernstein Liebhard LLP ... in the United States District Court for the District of ... (the "Class") consisting of all persons or entities who purchased ... (NASDAQ: INSY ) from March 3, 2015 through January ... certain of its officers with violations of the Securities Exchange ...
Breaking Medicine Technology: