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Fred Hutchinson Cancer Research Center to lead Immunotherapy Clinical Trials Network
Date:4/6/2011

eries of three NCI immunotherapy workshops conducted between 2007 and 2009 during which participants prioritized a list of agents with high potential to serve as immunotherapeutic drugs for cancer. While all of these agents had proven immunologic or physiologic function, even today, none are broadly available for testing in patients with cancer.

"The goal of the CITN is to conduct studies likely to make effective immunotherapy agents broadly available for cancer therapy," said Cheever. "The testing of novel immunotherapy agents for clinical use in cancer treatment involves several hurdles to clear. A network of top immunotherapists will have better access to the priority agents and be better suited to design and carry out the trials than individual scientists running single trials alone," said Cheever.

There are many existing agents for activating and augmenting immune responses. One of the difficulties in developing cancer immunotherapy agents is that the drugs are not likely to do much on their own, but will need to be used in combinations of two or more, said Cheever. The reason for this is that T cells, the immune cells that have the potential to specifically attack cancer cells, need to be selectively activated, expanded in number and stimulated to survive long-term. It is unlikely that a single compound could accomplish all of these steps, especially as the treatments will also need to override the natural checks and balances our bodies have in place to prevent overexpansion of T cells.

The CITN will be managed in concert with the federally funded HIV Vaccine Trials Network, also based at the Hutchinson Center. Data coordination will be operated by the NCI's Cancer Trials Support Unit, managed by Westat, a Washington-based contract research organization.

CITN member institutions and their principal investigators are listed in the table below:

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Contact: Dean Forbes
dforbes@fhcrc.org
206-667-2896
Fred Hutchinson Cancer Research Center
Source:Eurekalert

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