For the fruit fly, everything changes...( This release is also available in a h...),Health

This release is also available in German.

IMP Director Barry Dickson and his group are interested in the genetic basis of innate behaviour. They focus on the reproductive behaviour of the fruit fly Drosophila melanogaster. Two years ago, the team was able to identify the fruitless gene as a key regulator of mating behaviour.

For 20 years, scientists have been trying to identify another molecular switch which changes the behaviour of female insects after mating. It makes them lose interest in further sexual contact and start laying eggs. Mosquitoes, once fertilized, look out for a meal of blood and may transmit the malaria parasite along the way.

The trigger for the behavioral switch is a factor present in the seminal fluid of male insects. This sex peptide (SP), as it is called in Drosophila, has been known to scientists for quite a while. Nilay Yapici, a PhD student in Barry Dicksons team, has now identified the receptor (SPR) responsible for the effect of SP and thus revealed the underlying molecular mechanism. She also showed that the gene for SPR is active in the reproductive organs as well as the brain of the flies.

To get this far, it took two years of painstaking work and a scientific tool which was developed over the past few years by the Dickson group. This Drosophila RNAi Library is a collection of 22,000 fly strains and has recently been made available to researchers worldwide. Due to this collection, it is now possible to switch off any chosen gene in the fly. By doing so, neurobiologists are able to identify genes that influence behaviour.

Nilay Yapici studied 22,000 female flies and observed how they behaved after mating. In 130 cases, she found flies which continued to mate and laid very few or no eggs. Further evaluation of these genes and subsequent experiments with cell cultures led to the identification of the lo
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