Finnish researchers find a compound that prevents the growth of prostate ca... ( Evidence pointing to the effects of ...)

Navigation Links

Biology News Medicine News Biology Products Medicine Products Biology Definition Medicine Definition Biology Technology Medicine Technology Biology Dictionary Medicine Dictionary

HOME >> MEDICINE >> NEWS

Finnish researchers find a compound that prevents the growth of prostate cancer cells

Date:12/20/2010

Evidence pointing to the effects of monensin emerged in a project investigating the effects of nearly 5,000 drugs and micromolecules on the growth of prostate cancer cells. The project involved most of the drugs on the market today. Researchers found that small amounts of compounds disulfiram (Antabus), thiram, tricostatin A, and monensin can prevent the growth of prostate cancer cells without significant effects on the growth of the normal human prostate epithelial cells.

Further studies revealed that monensin caused prostate cancer cell death by reducing the amount of testosterone receptor and by increasing production of reactive oxygen species and inducing DNA damage. In addition, monensin was shown to have combined effects with anti-androgens the drugs suppressing the effects of androgens in preventing prostate cancer cell growth.

"These research findings give rise to a potential new use for the monensin. The results also demonstrate that the effects of anti-androgens in suppressing the growth of cancer cells can be enhanced by using drugs inducing production of reactive oxygen species", say Senior Research Scientist Kristiina Iljin from VTT and Research Scientist Kirsi Ketola from the University of Turku.

The research findings concerning the effects of drugs and micromolecules were published in the Clinical Cancer Research journal in 2009. The effects of monensin on preventing the growth of prostate cancer was published in the Molecular Cancer Therapeutics journal in December 2010.

Recently, medical companies have shown great interest in these kinds of projects aiming at finding novel indications for established drugs. Since the dosage and adverse effects of drugs already in use and their combined effects with other drugs are relatively well known, this kind of drug repositioning may result in considerable cost savings.

Prostate cancer is the second most common cause of cancer death in men after l
'/>"/>

Contact: VTT, Senior Research Scientist Kristiina Iljin
kristiina.iljin@vtt.fi
358-020-722-2839
VTT Technical Research Centre of Finland
Source:Eurekalert

0

GOOD

Page: 1 2
Related medicine news :

1. Ben-Gurion U. researchers: High resistance rates among acute otitis media pathogens in children
2. Breast inflammation is key to cancer growth, Kimmel Cancer Center researchers say
3. Researchers discover new signaling pathway linked to inflammatory disease
4. UCI researchers find novel memory-enhancing mechanism in brain
5. Researchers make critical leukemia stem cell discovery
6. U-M researchers discover way to block neurodegeneration in an adult form of Fragile X syndrome
7. Leibniz Prize 2011: 10 researchers awarded €2.5 million ($3.3 million) each
8. Researchers Turn Stem Cells Into Intestinal Tissue in Lab
9. Expert analysis of HER2 tests reveals issues with reliability, Mayo Clinic researchers say
10. Researchers establish new rule to predict risk of stroke, death from surgery that prevents it
11. Hospital shootings rare, but rate of other assults high, Johns Hopkins researchers find

Post Your Comments:

(Date:5/20/2013)... ESMO 32nd ESTRO European Cancer Congress will take ... ), from Friday 17 September to Tuesday 1 October ... The congress will build on the success of the ... Medical Oncology) and ESTRO (European Society for Therapeutic Radiology ... in Europe to offer presentations of cutting-edge research across ...

(Date:5/20/2013)... 2013 Ariosa Diagnostics, maker of the ... syndrome and other chromosome conditions, has announced today the ... conceived or conceived using the patient’s own egg. ... analysis as an option to those women electing to ... the evaluation of fetal sex and sex chromosome genetic ...

(Date:5/20/2013)... Soliant Health, a leading specialty healthcare staffing provider ... its fifth annual Most Beautiful Hospitals in the U.S. contest. ... decided to bypass its routine selection process and include not ... be in the running for the 2013 Most Beautiful Hospitals ... and runs through June 23. Winners will be revealed on ...

(Date:5/20/2013)... Cayman, Cayman Islands (PRWEB) May 20, 2013 ... knowledge-based, high tech Special Economic Zone in the ... Referral Network, an initiative to grow the zone’s ... with Cayman’s business-friendly environment and tax benefits are ... many of them referrals from zone channel partners. ...

(Date:5/20/2013)... Jointly established by The Hong ... (Sichuan U), China's first Institute for Disaster ... officially opened. Both institutions also held the ... Reduction" to conclude lessons learnt from Wenchuan ... Margareta Wahlström, Special Representative of the Secretary-General ...

[0] Media registration for the European Cancer Congress [0] Ariosa Diagnostics Expands Harmony Prenatal Test to Twin Pregnancies and Launches New X,Y Analysis Test [0] Vote for Soliant Health's 2013 Most Beautiful Hospitals in the U.S.[0] Cayman Enterprise City Introduces Referral Network [0] PolyU and Sichuan U Jointly Set Up China's First Institute for Disaster Management and Reconstruction

... identified a possible cause for the loss of a tumour ... development of more aggressive forms of prostate cancer. , ... prostate cancer develops because we now have some insight into ... Jeremy Squire, a professor in the Department of Pathology and ...

... HPV infection is more common among men than women, explaining ... HPV related head and neck cancer, according to a study ... by AHNS, ASCO, ASTRO and SNM., Human papillomavirus, or HPV, ... neck cancer that are becoming more prominent in the United ...

... or without chemotherapy is less effective for patients with HIV ... patients who do not have HIV, according to a study ... by AHNS, ASCO, ASTRO and SNM. , Treating head and ... Because of the advancements in treating HIV, these patients are ...

... of positron emission tomography/computed tomography (PET/CT) scans in head ... before they become clinically apparent and may improve the ... presented at the Multidisciplinary Head and Neck Cancer Symposium, ... is a relatively new test and its use as ...

... HOUSTON Scientists have connected two signature characteristics of pancreatic ... a new potential target for drugs to treat one of ... in the journal Cancer Cell and led by ... connected the molecular dots between: Mutated versions ...

... By Steven Reinberg HealthDay Reporter , WEDNESDAY, ... developing high blood pressure, diabetes or other risk factors for ... attack or stroke by age 80 than their less healthy ... to middle age with an optimal profile, it,s really like ...

Cached Medicine News:Health News:Oral HPV infection, HPV-related cancers more common in men 2 Health News:Standard treatments for head and neck cancer less effective in HIV-positive patients 2 Health News:Mutated Kras spins a molecular loop that launches pancreatic cancer 2 Health News:Mutated Kras spins a molecular loop that launches pancreatic cancer 3 Health News:Optimal Heart Health Starts Early: Study 2 Health News:Optimal Heart Health Starts Early: Study 3

New Queen's University research sheds light on gene destruction linked to aggressive prostate cancer Oral HPV infection, HPV-related cancers more common in men Standard treatments for head and neck cancer less effective in HIV-positive patients Routine follow-up scans can detect head and neck cancer recurrences earlier Mutated Kras spins a molecular loop that launches pancreatic cancer Optimal Heart Health Starts Early: Study

(Date:5/17/2013)... , May 17, 2013 Orexigen® Therapeutics, Inc. (Nasdaq: ... a company overview at the UBS Global Healthcare Conference in ... for Wednesday, May 22 nd at 11 a.m. Eastern ... of the presentation, please visit the Investor Relations section of ... will be available for 14 days after the event. ...

(Date:5/17/2013)... 17, 2013 Sony Biotechnology Inc. ("Sony") today announced the ... and 130um sorting chip. Sony will also be exhibiting its ... SH800 Cell Sorter, the EC800 flow cytometer, and new SP6800 ... 2013, which will be held at the San ... California , from May 20 - 22. ...

(Date:5/17/2013)... -- Research explores data on treatments ... to be presented Shire ... global specialty biopharmaceutical company, announces that it will present ... Psychiatric Association (APA) 166th Annual Meeting in ... presented represent Shire,s ongoing commitment to the clinical research ...

[0] Orexigen Therapeutics to Present at the UBS Global Healthcare Conference [0] Sony Delivers New Technology for Science to CYTO 2013 [0] Shire to Present Scientific Data Across a Range of Psychiatric Disorders at American Psychiatric Association Annual Meeting

... Ontario, Sept. 2, 2011 Valeant Pharmaceuticals International, Inc. (NYSE: ... members of its senior management team will be participating at ... and Chief Executive Officer will make a presentation at the ... London on Thursday, September 15, 2011 at 10:35 a.m. BT ...

... Lifetime Products, Inc. -- a worldwide Utah-based manufacturer ... storage sheds, and lawn and garden products -- announced ... adding a new Health and Wellness product category. ... will feature products like the award-winning Lifetime Tru-Motion™ ...

Cached Medicine Technology:Lifetime Products Enters New Product Category: Health and Wellness 2

Valeant Pharmaceuticals to Present at Industry Conferences Lifetime Products Enters New Product Category: Health and Wellness

Spetzler titanium microsurgical instrument. Small spatula dissector, bayonet, angled up 30°....

Instrument for transphenoidal hypophysectomy, bayonet-shaped, dissector, sharp inner edge, left....

Cushing-landolt bi-valve speculum for trans-sphenoidal hypophysectomie....

Hardy pituitary spoon, bayonet, malleable....

Medicine Products:

Small Spatula Dissector Hardy Dissector Cushing-Landolt Bi-valve Speculum Hardy Pituitary Spoons