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Encouraging findings suggest new avenues for treating liver disease in overweight Americans
Date:10/18/2010

versus 16 percent of those on placebo (p=0.01). Pentoxifylline significantly improved steatosis (fat in the liver) and inflammation, but no significant changes in ballooning were observed. A trend suggesting lack of progression of fibrosis (scar tissue in the liver) was also noted in the pentoxifylline group compared to placebo.

"There is a need for effective treatments for NASH. Previous experimental and pilot data suggesting potential benefits of pentoxifylline in NASH encouraged us to conduct this randomized, placebo controlled trial," explained Dr. Zein.

"The higher frequency of biochemical and histological improvement observed in our study among patients who received pentoxifylline compared to placebo, suggest both a reason for hope and a need for further studies," added Dr. Zein. She advises that physicians should suspect and investigate for fatty liver disease among patients who are at high risk, including those who are overweight, diabetic, or have other elements of the metabolic syndrome. "General recommendations in the management of patients with fatty liver disease include weight reduction for obese patients, and optimized management of the components of the metabolic syndrome, if present. However, there is still a need for effective medical therapeutic agents for NASH, and that is why the results of this study are so encouraging," Dr. Zein concluded.

Indiana Study Explores Changes in Adipose Tissue Insulin Resistance in NASH

Although insulin sensitizers have been the main focus for developing new treatments for NASH, the study by Dr. Zein and another study by the NIDDK‐funded NASH Clinical Research Network (NASH CRN) presented at the ACG Annual Scientific meeting in San Antonio as a late breaking abstract indicate that pathways other than insulin resistance could be used for developing effective treatments for NASH.

The investigators from the NASH CRN have recently published a paper in The New England Journal of Medi
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Contact: Jacqueline Gaulin
jgaulin@acg.gi.org
202-255-5541
American College of Gastroenterology
Source:Eurekalert

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