drugstore.com inc. Reports Results for the First Quart...(is included in the financial data accomp...),Health

this press release.

2. Net sales from repeat customers exclude Weil-related CNS net sales and

reflect only the activity of customers making purchases through the

Web sites of drugstore.com and its subsidiaries.

3. Active customer base reflects those customers who have purchased at

least once within the last 12 months. Both the active customer base (a

trailing 12-month number) and average annual spend per active customer

exclude net sales and orders generated by the company's CNS

fulfillment relationship with Weil, and reflect only the activity of

customers making purchases through the Web sites of drugstore.com and

its subsidiaries.

Conference Call

Investors, analysts, and other interested parties are invited to join the drugstore.com, inc. quarterly conference call on May 5, 2008 at 5:00 p.m. ET (2:00 p.m. PT). To participate, callers should dial 800-240-6709 (international callers should dial 303-262-2141) five minutes beforehand. Investors may also listen to the conference call live at http://investor.drugstore.com/, by clicking on the "audio" hyperlink. A replay of the call will be available through Wednesday, May 7, 2008 by dialing 800-405-2236 (enter pass code 11112232#) or internationally at 303-590-3000 (enter pass code 11112232#) beginning two hours after completion of the call.

Non-GAAP Measures

To supplement the consolidated financial statements presented in accordance with GAAP, drugstore.com, inc. uses the non-GAAP measure of adjusted EBITDA, defined as earnings before interest, taxes, depreciation, and amortization of intangible assets and non-cash marketing expenses, adjusted to exclude the impact of stock-based compensation expense. This non-GAAP measure is provided to enhance the user's overall understanding of the
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