Navigation Links
Drug Targets Faulty Process That Drives Cystic Fibrosis
Date:11/17/2010

ydrated.

Overtime, the abnormal mucus builds up in the lungs and in the pancreas, which helps to break down and absorb food, causing both breathing and digestive problems.

In the lungs, the accumulation of the mucus leaves people prone to serious, hard-to-treat and recurrent infections. Overtime, the repeated infections destroy the lungs.

The average life expectancy for a person with cystic fibrosis is about 37, according to the Cystic Fibrosis Foundation.

While inhaled antibiotics and other treatments have led to substantial improvements in life expectancy, no treatments specifically target the CFTR protein. That's where VX-770 comes in, said Dr. Frank Accurso, lead study author and a professor of pediatrics at University of Colorado Denver and The Children's Hospital in Denver.

With $76 million in funding from the Cystic Fibrosis Foundation, Vertex Pharmaceuticals screened hundreds of thousands of molecules in the lab, searching for those that might work to alter the chloride channels in cystic fibrosis cells.

"You can think of the gate as being closed," Accurso said. "What this treatment does is open up the gate, allowing the chloride channel to open and the water to get out."

In the Phase II trial, 39 adults with cystic fibrosis took either the drug or a placebo for two weeks, and then again for 28 days. All patients had the G551D mutation, present in 4 to 5 percent of patients, according to the study.

Tests showed that not only did lung function improve, participants reported feeling better.

Levels of chloride in sweat also fell, indicating the drug is working on the cellular level to better regulate the release of chloride.

"That is telling us that we have improved the function of the CFTR," Accurso said.

The primary objective of the study was to evaluate the safety and tolerability of the drug. There was no difference in the frequency of reported adverse events among those taking the drug
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. New Study: Improved Immune System with Gene-Eden, a Natural Antiviral Supplement that Targets Chronic Viruses
2. Hot Pepper Itch Remedy Targets Kidney Disease Patients Suffering From Chronic Pruritus
3. Scott & White Healthcare researchers studying investigational agent that targets breast cancer
4. Global Leader Readied For Healthy Aging Boom, Targets Wall Street With New Center In Trump Building
5. FDA Targets Safety Problems With Infusion Drug Pumps
6. Global Summit on International Breast Health Targets Breast Health Improvements in Developing Countries, June 9-11, 2010, in Chicago
7. Combination therapy targets stubborn leukemia stem cells
8. Miami meeting on radiation therapy targets patient safety
9. Researcher targets gene regulators on link between arsenic, cancer
10. MSU targets womens health research with $2.5 million grant
11. TGen finds therapeutic targets for rare cancer in children
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drug Targets Faulty Process That Drives Cystic Fibrosis
(Date:7/24/2014)... Journal of Oral Implantology —Success of a ... the alveolar ridge—an indication of the amount of bone ... exist, each with their own advantages, to determine bone ... highlighted as a strategy for treating horizontally collapsed alveolar ... comparison of two commonly used techniques , the ...
(Date:7/24/2014)... The U.S. Preventive Services Task Force recently ... at high risk for cancer, but a potential ... have positive results on the screening test, only ... policymakers have expressed concern that this high false-positive ... A new study of National Lung Screening Trial ...
(Date:7/24/2014)... Voted one of the most reliable online dress ... on providing its new and old customers with the ... has announced its new collection of high end wedding ... according to the latest fashion trends. Additionally, they are ... , As a matter of fact, high end special ...
(Date:7/24/2014)... 2014 Four Seasons Resort Maui ... its $3 million renovation of the famed Maile suite ... suites, just in time to welcome summer guests vacationing ... direction from the internationally-acclaimed BraytonHughes Design Studios, San Francisco ... property and the largest in Hawaii—received a complete re-envisioning. ...
(Date:7/24/2014)... HealthDay Reporter THURSDAY, July 24, 2014 (HealthDay News) -- ... according to a small study that asked boys what they really ... the ages of 14 and 16, researchers found that most said ... trust. Very few boasted about sexual conquests or saw sex as ... "In our culture, we have lots of assumptions about how guys ...
Breaking Medicine News(10 mins):Health News:A Comparison of Graft Techniques for the Alveolar Ridge Prior to Oral Implant 2Health News:A Comparison of Graft Techniques for the Alveolar Ridge Prior to Oral Implant 3Health News:Informed consent: False positives not a worry in lung cancer study 2Health News:Informed consent: False positives not a worry in lung cancer study 3Health News:BellasDress Helps Brides Get High End Wedding Dresses for Their Romantic Weddings 2Health News:Four Seasons Resort Maui's Newly Designed Top Suites Debut 2Health News:Four Seasons Resort Maui's Newly Designed Top Suites Debut 3Health News:Four Seasons Resort Maui's Newly Designed Top Suites Debut 4Health News:Four Seasons Resort Maui's Newly Designed Top Suites Debut 5Health News:Teenage Boys Want Intimacy, Not Just Sex, Survey Finds 2Health News:Teenage Boys Want Intimacy, Not Just Sex, Survey Finds 3
... By Steven Reinberg HealthDay Reporter , TUESDAY, ... called infective endocarditis, coupled with heart failure, heart valve surgery ... new study suggests. Infective endocarditis, an infection of ... valves, has been associated with a high risk of death. ...
... , TUESDAY, Nov. 22 (HealthDay News) -- ,Taking slightly ... the brand name Tylenol) over time can lead to an ... a new study. These "staggered overdoses" can occur when ... acetaminophen than they should, explained Dr. Kenneth Simpson, author of ...
... By Steven Reinberg HealthDay Reporter , TUESDAY, ... "energy" drinks skyrockets, so do related health problems, a ... almost 10 times more cases of reactions to beverages such ... to a new U.S. government report released Tuesday. More ...
... , TUESDAY, Nov. 22 (HealthDay News) -- Elderly black ... are much more likely to die in the hospital than ... risk of death was present even when black patients had ... researchers found. Diverticulitis occurs when small pouches in the ...
... discovered the novel protective role dendritic cells play in ... issue of journal Gastroenterology , shows dendritic cells ... dangerous swelling and inflammation of the pancreas gland. ... dendritic cells are needed in the pancreas for normal, ...
... News) --,College students tend to smoke when they are partying, ... are using social events and work as cues to remind ... an assistant professor of family and community medicine at the ... "This research is important for those working with college students ...
Cached Medicine News:Health News:Surgery May Boost Survival With Dangerous Heart Condition 2Health News:Surgery May Boost Survival With Dangerous Heart Condition 3Health News:Too Much Acetaminophen Over Time May Damage Liver 2Health News:ER Visits for Energy-Drink Ills Soar in U.S. 2Health News:ER Visits for Energy-Drink Ills Soar in U.S. 3Health News:More Blacks Die in Hospital After Diverticulitis Surgery 2Health News:Dendritic cells protect against acute pancreatitis 2Health News:Dendritic cells protect against acute pancreatitis 3Health News:College Students Smoke When They Party, Drink and Work 2
(Date:7/24/2014)... , July 24, 2014  In any given hospital ... 25 patients has at least one hospital-acquired infection, according ... more, many of these infections prove fatal. And as ... alarming number of patient deaths per year, infection control ... Consequently, a stronger emphasis is being ...
(Date:7/24/2014)... DALLAS , July 24, 2014 /PRNewswire-iReach/ -- ... days once order is placed. Photo ... is a professional and in-depth market survey on ... firstly reviews the basic information of Hemodialysis Machine ... report then explores global and China,s top manufacturers ...
(Date:7/24/2014)... -- Questcor Pharmaceuticals, Inc. (NASDAQ: QCOR ) today ... 2014. Three Months Ended 06/30/14Three Months Ended 06/30/13 ,  Percentage ... 51% Non-GAAP Net Sales , $278.8 Million , $196.1 ... , $1.12 , 37% Non-GAAP Diluted ... 37%  Six Months Ended 06/30/14Six Months Ended 06/30/13 , ...
Breaking Medicine Technology:Employees, Equipment and the Environment: Top Infection Prevention Focuses in Hospitals 2Employees, Equipment and the Environment: Top Infection Prevention Focuses in Hospitals 3Hemodialysis Machine Industry for Global and Chinese Markets Forecast to 2019 2Hemodialysis Machine Industry for Global and Chinese Markets Forecast to 2019 3Hemodialysis Machine Industry for Global and Chinese Markets Forecast to 2019 4Hemodialysis Machine Industry for Global and Chinese Markets Forecast to 2019 5Questcor Reports Record Second Quarter Financial Results 2Questcor Reports Record Second Quarter Financial Results 3Questcor Reports Record Second Quarter Financial Results 4Questcor Reports Record Second Quarter Financial Results 5Questcor Reports Record Second Quarter Financial Results 6Questcor Reports Record Second Quarter Financial Results 7Questcor Reports Record Second Quarter Financial Results 8Questcor Reports Record Second Quarter Financial Results 9Questcor Reports Record Second Quarter Financial Results 10Questcor Reports Record Second Quarter Financial Results 11Questcor Reports Record Second Quarter Financial Results 12Questcor Reports Record Second Quarter Financial Results 13Questcor Reports Record Second Quarter Financial Results 14Questcor Reports Record Second Quarter Financial Results 15Questcor Reports Record Second Quarter Financial Results 16Questcor Reports Record Second Quarter Financial Results 17Questcor Reports Record Second Quarter Financial Results 18Questcor Reports Record Second Quarter Financial Results 19Questcor Reports Record Second Quarter Financial Results 20Questcor Reports Record Second Quarter Financial Results 21Questcor Reports Record Second Quarter Financial Results 22Questcor Reports Record Second Quarter Financial Results 23Questcor Reports Record Second Quarter Financial Results 24Questcor Reports Record Second Quarter Financial Results 25Questcor Reports Record Second Quarter Financial Results 26Questcor Reports Record Second Quarter Financial Results 27Questcor Reports Record Second Quarter Financial Results 28
... WaferGen Biosystems, Inc. (OTC Bulletin Board: WGBS ... today announced that it has appointed world-renowned clinical genomics ... Scientific Advisory Board.   Dr. Chinnaiyan is ... the clinic to choose appropriate therapies for cancer patients. ...
... SAN DIEGO, Jan. 19, 2011 ADVENTRX Pharmaceuticals, Inc. (NYSE ... Food and Drug Administration (FDA) has established a Prescription Drug ... the review of the Exelbine (ANX-530) New Drug Application (NDA). ... that the application is sufficiently complete to permit a substantive ...
Cached Medicine Technology:WaferGen Appoints World-Renowned Clinical Genomics Cancer Researcher Dr. Arul M. Chinnaiyan to Scientific Advisory Board 2WaferGen Appoints World-Renowned Clinical Genomics Cancer Researcher Dr. Arul M. Chinnaiyan to Scientific Advisory Board 3WaferGen Appoints World-Renowned Clinical Genomics Cancer Researcher Dr. Arul M. Chinnaiyan to Scientific Advisory Board 4ADVENTRX Pharmaceuticals Receives PDUFA Date for Exelbine™ NDA 2ADVENTRX Pharmaceuticals Receives PDUFA Date for Exelbine™ NDA 3
... (PxE) is a licensed 96 well PCR machine, ... for money thermal cycling. It is built ... in manufacturing and retains a high level of ... products in the range. The combination of ...
Custom programming of 3 hot blocks and 1 cold block, 30% reduction in cycling time, Unmatched well-to-well uniformity, No gradient feature...
... With Exceptional Performance The sleek ... might be the first things ... is designed for performance. With ... premium, its small footprint is ...
... The 96-Well GeneAmp PCR System 9700 ... and Aluminum Sample Blocks Modules. The aluminum ... of PCR reactions and cycle sequencing in ... This allows the 96-well 9700 system to ...
Medicine Products: