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Clinical trials launched for treating most aggressive brain tumor with personalized cell vaccines
Date:11/30/2009

fundamental tool in the operating theatre - the fluorescent microscope -, with which the percentage of tumour extirpation has increased enormously.

In concrete, the surgical fluorescent microscope has enabled specialists at the Hospital to reach the total extirpation of glioblastomas in more than 80% of the cases operated over the last two years. After the extirpation, the tumour tissue obtained has to be sent - in conditions of maximum sterility - directly to the Pathological Anatomy Laboratory to corroborate or contradict the diagnosis. If the tumour is confirmed to be a glioblastoma, the tumour tissue is then transferred to the Cell Therapy GMP Laboratory at the Hospital for its processing and the subsequent obtaining of personalised vaccines produced with the tissue of each patient taking part in the clinical trials.

Production of personalised vaccines

The personalised vaccines are produced in the Cell Therapy GMP Laboratory at the University of Navarra Hospital given its advance therapy medication nature and having to be produced under correct manufacturing norms. They are treated as individualised (personalised) units of medication, each being produced by the combination of two elements obtained from the patient him or herself: the dendritic cells (of the immune system) and the tumour cells (obtained and processed from the tumour itself).

The dendritic cells are obtained by a process known as leukapheresis which involves the separation and extraction of white blood cells from the rest of the patient's blood, and returning it to the organism.

After the pheresis and by means of immunomagnetic selection, monocytes are obtained - a type of white blood cell the function of which in the body is to pass to the tissues, converting themselves into dendritic cells and capture antigens (molecules capable of triggering an immune response), amongst these tumoural antigens. Once captured, the dendritic cells teach the lymphocy
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Contact: Oihane Lakar
oihane@elhuyar.com
0034-943-363-040
Elhuyar Fundazioa
Source:Eurekalert

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