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Clinical trials launched for treating most aggressive brain tumor with personalized cell vaccines
Date:11/30/2009

ersity of Navarra Hospital. In that case, the procedure was based on the production and administration of idiotype vaccines and personalised for patients with first relapse follicular lymphoma. The trials demonstrated clinical efficacy on managing to change the progress of the illness.

More than 2,400 new cases each year in Spain

The glioblastoma is the most common malignant tumour of the brain. The rate is about 6 cases for every 100,000 inhabitants per year, which means that in Spain 2,400 new cases appear every year. There is no effective treatment currently, making it one of the ten tumours causing the greatest number of deaths annually. In concrete, patients with a glioblastoma, and who have been treated with the standard procedure, have an average survival period of between 12 and 15 months. Nevertheless, in the few cases studied worldwide, a number of patients undergoing immunotherapy have survived longer, the average rate being more than 30 months.

Basis of the trials

The basis of the trials developed by the Hospital is the hypothesis that the immune system of each person is capable of recognising and destroying tumour cells. This ability lies in the fact that tumour cells have surface markers different from those of healthy cells, to the point where the organism itself can detect these makers and produce antibodies and cell toxicity against incipient tumour cells. However, when the tumour has grown, the immune system is incapable of controlling it.

In this way, the new treatment currently being tested by the University of Navarra Hospital is trying to load the dendritic cells, responsible for directing and co-ordinating the immunity of the organism, with undesired tumour antigens, so that the cells of the immune system are activated and the body's defences are aimed at the remains of the tumour at a time when tumour cells are scarcer, i.e. after the extirpation of the tumour and the application of radio-chemo
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Contact: Oihane Lakar
oihane@elhuyar.com
0034-943-363-040
Elhuyar Fundazioa
Source:Eurekalert

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