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Clinical trials launched for treating most aggressive brain tumor with personalized cell vaccines
Date:11/30/2009

The University of Navarra Hospital has launched a series of clinical trials in order to assess the efficacy of an immunotherapy treatment. This approach involves the application of personalised vaccines produced from healthy and tumour cells from the patient him or herself and designed to combat glioblastomas, one of the most aggressive and frequent malignant tumours. The new therapy is administered to participating patients combined with the standard, first-line treatment involving surgical extirpation of the tumour followed by radiotherapy and chemotherapy treatment with temozolomide. The Hospital is currently the only centre in Spain undertaking a study of this nature, and for which it has recently received authorisation from the Medication Agency of the Spanish Health Ministry. It is planned to involve a sample of 37 patients for the research.

The trials have been devised and developed by the Neuro-oncology and Cell Therapy Areas of the University of Navarra Hospital, in collaboration with the Centre for Applied Medical Research (CIMA) through the Scientific and Technological Institute (ICT) of the same university. The investigation has received funding from FIS (Health Research Fund) announcement by the Ministry of Health for financing the development of non-commercial pharmaceutical drugs.

In essence, the production of the personalised vaccines is carried out at the University of Navarra Hospital's Cell Therapy Good Manufacturing Practices Laboratory, where tumour proteins are processed and then combined with immune system cells obtained from the patient's blood, which are taught how to organise an immune response to the tumour. These prepared items are frozen and then administered to the patient as vaccines over the following months, in combination with conventional therapy.

It should be recalled that an immunotherapy treatment with similar characteristics was developed over two years ago by a research team at CIMA and the Univ
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Contact: Oihane Lakar
oihane@elhuyar.com
0034-943-363-040
Elhuyar Fundazioa
Source:Eurekalert

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