Navigation Links
Cancer Cells May Be Able to Urge Their Own Death
Date:12/22/2010

WEDNESDAY, Dec. 22 (HealthDay News) -- New research suggests that many cancer cells are equipped with a kind of suicide pill: a protein on their surfaces that gives them the ability to send an "eat me" signal to immune cells.

The challenge now, the researchers say, is to figure out how to coax cancer cells into emitting the signal rather than a dangerous "don't eat me" signal.

A study published online Dec. 22 in Science Translational Medicine reports that the cells send out the enticing "eat me" signal by displaying the protein calreticulin. But another molecule, called CD47, allows most cancer cells to avoid destruction by sending the opposite signal: "Don't eat me."

In earlier research, Stanford University School of Medicine scientists found that an antibody that blocks CD47 -- turning off the signal -- could help fight cancer, but mysteries remained.

"Many normal cells in the body have CD47, and yet those cells are not affected by the anti-CD47 antibody," Mark Chao, a Stanford graduate student and the study's lead author, said in a university news release. "At that time, we knew that anti-CD47 antibody treatment selectively killed only cancer cells without being toxic to most normal cells, although we didn't know why."

Now, the new research has shown that calreticulin exists in a variety of cancers, including some types of leukemia, non-Hodgkin's lymphoma and bladder, brain and ovarian cancers. "This research demonstrates that the reason that blocking the CD47 'don't eat me' signal works to kill cancer is that leukemias, lymphomas and many solid tumors also display a calreticulin 'eat me' signal," Dr. Irving Weissman, director of the Stanford Institute for Stem Cell Biology and Regenerative Medicine and a co-principal investigator of the study, said in the release. "The research also shows that most normal cell populations don't display calreticulin and are, therefore, not depleted when we expos
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved  

0

GOOD

Page: 1 2

Related medicine news :

1. Enhancing arrest of cell growth to treat cancer in mice
2. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
3. The National Coalition for Cancer Survivorship Joins the Commission on Cancer
4. Low forms of cyclin E reduce breast cancer drugs effectiveness
5. Racial disparities persist in the diagnosis of advanced breast cancer and colon cancer in the U.S.
6. Soft drinks may increase risk of pancreatic cancer
7. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
8. Genes Play Role in Prognosis With Non-Small Cell Lung Cancers
9. Single gene mutation induces endometrial cancer
10. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
11. Molecular pathways linked to sex, age affect outcomes in lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cancer Cells May Be Able to Urge Their Own Death
(Date:6/17/2013)... Cell Institute (HSCI) researchers have identified in the most ... embryonic stem cell self-renewal, beginning a creative search for ... gene, SALL4, gives stem cells their ability to continue ... Typically, cells only express SALL4 during embryonic development, but ... acute myeloid leukemia and 10 to 30 percent of ...
(Date:6/17/2013)... The Woodstock Fruit Festival is proud to extend an ... which will be held in Diamond Point, New York from ... professes the benefits he's received by regularly eating up ... class sprinting abilities. Fruit is commonly considered health food, but ... Blake believes in the power of natural foods, and the ...
(Date:6/17/2013)... 2013 MelanSol® All Natural Skin Care ... the US distributor for MelanSol®, has partnered with the ... Food Bank to support their efforts to feed ... that they receive a portion of every sale of ... Moisturizer. Contributions will be given on sales from ...
(Date:6/17/2013)... YORK, NY (June 17, 2013) A team from ... and the Naomi Berrie Diabetes Center of Columbia University ... accurately reflect the features of maturity-onset diabetes of the ... of MODY patients to produce induced pluripotent stem (iPS) ... into a mouse, the stem cell-derived beta cells secreted ...
(Date:6/17/2013)... Tarrant Plastic Surgery is pleased to announce a summer mommy ... undergone a mainstream culture explosion. Interpretation of the term may ... regard the term to mean a combination of breast and ... effects of pregnancy on a woman’s body. , Effects ... with gain or loss of volume, widening of the nipple ...
Breaking Medicine News(10 mins):Health News:A new target for cancer drug development 2Health News:Yohan Blake Invited to The Woodstock Fruit Festival as Guest of Honor 2Health News:All Natural Sunscreen Fights Hunger 2Health News:NYSCF and Columbia researchers demonstrate use of stem cells to analyze causes, treatment of diabetes 2Health News:NYSCF and Columbia researchers demonstrate use of stem cells to analyze causes, treatment of diabetes 3Health News:Tarrant Plastic Surgery Announces Summer Makeover Special 2
... Boston Scientific Corporation (NYSE: BSX ) ... Company 29th Annual Health Care Conference.Jim Tobin, Chief Executive ... 17th, beginning at approximately 3:55 p.m. E.T. Following ... Financial Officer will join Mr. Tobin in a question ...
... 10 Representatives Gene Green (D-TX), Ed Whitfield (R-KY), ... Mike Rogers (R-MI), Betty Sutton (D-OH), Bart Gordon (D-TN), ... H.R. 1392. This bill will amend title XVIII of ... amounts for drugs and biologicals under Part B of ...
... , , GEORGETOWN, Texas, March 10 ... provider, ranked 21st overall in the recent Dun & ... Clips is listed as the highest-ranked, fastest-growing hair-care franchise ... AllBusiness.com "Top 10 Franchises for Veterans." ...
... Coronado, Washington Four Seasons and seven additional hotels join ... Luxury hotel owner, Strategic Hotels, today announced that ... UNICEF-supported clean water campaign known as the Tap ... award-winning, lifesaving initiative helps UNICEF provide clean water to ...
... are highlights from the March issue of Mayo ... as often as you wish. Mayo Clinic ... Reprinting is allowed for a fee. Include the following ... www.bookstore.mayoclinic.com or call toll-free for subscription information, 800-876-8633, ...
... Ltd. announced today that OAD Orthopaedics of Warrenville, Illinois, has ... is designed to save precious clinical time for busy ... seeing large volumes of patients each day. When a ... a reader, and the images for that patient are instantly ...
Cached Medicine News:Health News:House Bill to Improve Accuracy of Medicare Reimbursement Introduced: Members of Congress Seek to Stem Growing Healthcare Coverage Shortfalls, Community Oncology Alliance Advocates for Swift Passage of Bill 2Health News:House Bill to Improve Accuracy of Medicare Reimbursement Introduced: Members of Congress Seek to Stem Growing Healthcare Coverage Shortfalls, Community Oncology Alliance Advocates for Swift Passage of Bill 3Health News:Sport Clips Tops Hair-care Franchises in '2009 AllBusiness AllStars' 2Health News:Tap Project Partners With Strategic Hotels for 2009 UNICEF Clean Water Campaign 2Health News:Tap Project Partners With Strategic Hotels for 2009 UNICEF Clean Water Campaign 3Health News:March 2009 Mayo Clinic Women's HealthSource Highlights Molecular Breast Imaging, Canes and Walkers, Training for an Event and Hormone Therapy for Women 2Health News:March 2009 Mayo Clinic Women's HealthSource Highlights Molecular Breast Imaging, Canes and Walkers, Training for an Event and Hormone Therapy for Women 3Health News:March 2009 Mayo Clinic Women's HealthSource Highlights Molecular Breast Imaging, Canes and Walkers, Training for an Event and Hormone Therapy for Women 4Health News:March 2009 Mayo Clinic Women's HealthSource Highlights Molecular Breast Imaging, Canes and Walkers, Training for an Event and Hormone Therapy for Women 5Health News:March 2009 Mayo Clinic Women's HealthSource Highlights Molecular Breast Imaging, Canes and Walkers, Training for an Event and Hormone Therapy for Women 6Health News:'Swipe Card, See Image': OAD Orthopaedics Improves Clinical Workflow with OrthoFlow 2
(Date:6/17/2013)... 2013 Velplex, LLC announced this week that ... that connects buyers and sellers of discount dental ... Why? It,s because the business leaders ... with the dental industry. They have 50 years of ... worked to negotiate some of the best prices in ...
(Date:6/17/2013)... , June 17, 2013 Vanda ... presented additional data today at ENDO 2013, the ... that tasimelteon can entrain (synchronize) both melatonin and ... to reset the master body clock and address ... Disorder (Non-24).  The SET (Safety and Efficacy of ...
(Date:6/17/2013)...  Hanger, Inc. (NYSE:  HGR) today announced the signing ... senior secured facilities to an aggregate of up to ... agreement includes a $200 million revolving credit facility and ... agreement was comprised of a $100 million revolving credit ... facility matures on June 17, 2018, and is subject ...
Breaking Medicine Technology:TopProdeals.com Rises to Top as Discount Dental Supply Leader 2Vanda Presents Data From Phase III Studies that Demonstrate Tasimelteon Restores Daily Cortisol Rhythm In Blind Patients With Non-24-Hour Disorder 2Vanda Presents Data From Phase III Studies that Demonstrate Tasimelteon Restores Daily Cortisol Rhythm In Blind Patients With Non-24-Hour Disorder 3Vanda Presents Data From Phase III Studies that Demonstrate Tasimelteon Restores Daily Cortisol Rhythm In Blind Patients With Non-24-Hour Disorder 4Hanger Enters New 5-Year Credit Agreement to Refinance Senior Secured Credit Facilities 2Hanger Enters New 5-Year Credit Agreement to Refinance Senior Secured Credit Facilities 3
... 2011 Watson Pharmaceuticals, Inc. (NYSE: ... has received U.S. Food and Drug Administration ("FDA") ... for Enoxaparin Sodium Injection in the 100mg/mL and ... equivalent to Sanofi-aventis, LOVENOX®, and is a low ...
... SYDNEY, Sept. 19, 2011 HeartWare International, Inc. (NASDAQ: ... innovator of less invasive, miniaturized circulatory support technologies that ... announced that CEO Doug Godshall is scheduled to present ... Device Day at 1:55 p.m. ET on Thursday, September ...
Cached Medicine Technology:Watson Pharmaceuticals Announces Approval of Amphastar's Generic LOVENOX(R) 2Watson Pharmaceuticals Announces Approval of Amphastar's Generic LOVENOX(R) 3HeartWare to Present at The Lazard Capital Markets 3rd Annual Circulatory Assist Device Day 2
... The model 55S Rocking Shaker provides ... and blotted membranes. The very slow ... degree of tilt provide a gentle ... over gels and blotted membranes to ...
Plate Roller...
Conversion Kits For Modular Incubator Chamber...
Multi-Tier Shaker...
Medicine Products: