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Brain's response to seeing food may be linked to weight loss maintenance
Date:9/15/2009

PROVIDENCE, RI A difference in brain activity patterns may explain why some people are able to maintain a significant weight loss while others regain the weight, according to a new study by researchers with The Miriam Hospital.

The investigators report that when individuals who have kept the weight off for several years were shown pictures of food, they were more likely to engage the areas of the brain associated with behavioral control and visual attention, compared to obese and normal weight participants.

Findings from this brain imaging study, published by the American Journal of Clinical Nutrition, suggest that successful weight loss maintainers may learn to respond differently to food cues.

"Our findings shed some light on the biological factors that may contribute to weight loss maintenance. They also provide an intriguing complement to previous behavioral studies that suggest people who have maintained a long-term weight loss monitor their food intake closely and exhibit restraint in their food choices," said lead author Jeanne McCaffery, PhD, of The Miriam Hospital's Weight Control and Diabetes Research Center.

Long-term weight loss maintenance continues to be a major problem in obesity treatment. Participants in behavioral weight loss programs lose an average of 8 to 10 percent of their weight during the first six months of treatment and will maintain approximately two-thirds of their weight loss after one year. However, despite intensive efforts, weight regain appears to continue for the next several years, with most patients returning to their baseline weight after five years.

Researchers used functional magnetic resource imaging (fMRI), a non-invasive technique that localizes regions of the brain activated during cognition and experience, to study the brain activity of three groups: 18 individuals of normal weight, 16 obese individuals (defined as a body mass index of at least 30), and 17
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Contact: Jessica Collins Grimes
jgrimes2@lifespan.org
401-793-7484
Lifespan
Source:Eurekalert

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