Navigation Links
Blood-based genomic test better than imaging test for ruling out obstructive coronary artery disease
Date:11/15/2011

measurements for diagnosis of coronary artery disease. A total of 431 patients were eligible for analysis, having completed gene expression testing, MPI and either invasive angiography or CTA.

In the COMPASS study, the gene expression test was superior to MPI in diagnostic accuracy, sensitivity (89 percent vs. 27 percent, p<0.001) and negative predictive value (96 percent vs. 88 percent, p<0.001) and demonstrated excellent performance for ruling out obstructive coronary artery disease relative to both invasive angiography and CTA.

Better methods for risk stratification of patients with obstructive coronary artery disease are needed. A study published in the March 11, 2010 issue of The New England Journal of Medicine found that in nearly 400,000 patients who underwent elective invasive angiographic procedures, 62 percent were found to have no obstructive coronary artery blockage.

The gene expression test used in the study, called Corus CAD (CardioDx, Palo Alto, Calif.), measures the RNA levels of 23 genes from a whole blood sample. Because these RNA levels are increased or decreased when obstructive coronary artery disease is present, the Corus CAD score indicates the likelihood that an individual patient does not have obstructive coronary artery disease.

"Chest pain symptoms account for two percent of all visits to the doctor's office each year," said Dr. Mark Monane, chief medical officer of CardioDx. "Corus CAD has now been validated in more than 1,100 patients in three separate studies. For physicians, methods to improve the diagnosis of symptoms suggestive of coronary artery disease represent a huge unmet need, and the Corus CAD test may help clinicians make better decisions. For patients, the test may lead to better diagnostic accuracy as well as avoidance of unnecessary procedures. For payers, we believe that Corus CAD can address a major expense category."


'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert  

0

GOOD

Page: 1 2

Related medicine news :

1. Toronto-based genomics center gets $5 million injection
2. From genomic data to new cancer drug
3. Dana-Farber, Brigham and Womens launch large-scale genomic database project
4. Structural Genomics Project creates blueprint for infectious disease and biodefense research
5. Lung tumors in never-smokers show greater genomic instability than those in smokers
6. Novel analysis method organizes genomic cancer data
7. Genomic test shows promise as chemotherapy response, survival predictor for women with breast cancer
8. Genomic signature in post-menopausal women may explain why pregnancy reduces breast cancer risk
9. New genomics research investigates metastatic childhood cancers
10. Promise of genomics research needs a realistic view
11. NHGRI charts course for the next phase of genomics research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Blood-based genomic test better than imaging test for ruling out obstructive coronary artery disease
(Date:6/19/2013)... According to Transparency Market Research “Endoscopy ... Analysis and Forecast, 2011 – 2017,” the global endoscopy ... year 2011 and is expected to reach USD 10.8 ... from 2011 to 2017. Flexible endoscopes formed the largest ... 2,201 million for the year 2011. , Related Report ...
(Date:6/19/2013)... Ore. For years, Alzheimer,s researchers have focused on ... with Alzheimer,s and may contribute to the disease: plaques ... another protein, called tau. , But for the first ... the two proteins independently, but at the interaction of ... brain tissue of post-mortem Alzheimer,s patients and in mouse ...
(Date:6/19/2013)... 19, 2013 AquaPrint Solutions in Thomson, IL ... Grub with a newly-designed Harley Davidson motorcycle gas tank. A ... Solutions with an idea of taking a split tank motorcycle ... and transforming it into a work of art. , ... Grub several toilet seats that had been dipped in a ...
(Date:6/19/2013)... 19, 2013 The Cancer Support Community ... of cancer care for the whole patient with the ... Cancer Support Community. This inaugural event, held at the ... MD., Ph.D., recognition of Congress members who have made ... of patients and families currently engaged in the cancer ...
(Date:6/19/2013)... (PRWEB) June 19, 2013 North ... PT continuing education course with an online ... therapy assistants and occupational therapists. , ... course supplemented by an online continuing education ... level algorithmic problem solving skills needed to evaluate ...
Breaking Medicine News(10 mins):Health News:Endoscopy Devices Market Will Reach USD 10.8 Billion in 2017 : Transparency Market Research 2Health News:Endoscopy Devices Market Will Reach USD 10.8 Billion in 2017 : Transparency Market Research 3Health News:New Alzheimer's research suggests possible cause: The interaction of proteins in the brain 2Health News:AquaPrint Solutions Transforms Harley Davidson Gas Tank into a Work Of Art for Poopy’s Pub & Grub 2Health News:Keeping the Promise of Cancer Care for the Whole Patient 2Health News:Keeping the Promise of Cancer Care for the Whole Patient 3Health News:New Evidence Based Information on Treatment for Over 8 Million People in the U.S. Affected With Disorders of the Vestibular System 2
... Nursing (NYUCN) received a four-year, $ 2.8M grant from ... and Infectious Diseases (NIH/NIAID) to study "Combination HIV ... is a collaboration between NYUCN, the University of Nairobi, ... Principal Investigator Ann Kurth notes that HIV ...
... FRIDAY, Oct. 28 (HealthDay News) -- Surgery to remove ... as a thyroidectomy, appears to reduce snoring and other ... study. Researchers compared symptoms in patients with obstructive ... a thyroidectomy. Symptoms of obstructive sleep apnea include snoring, ...
... -- In 2008, as part of a larger initiative aimed ... reimbursing for the treatment of injuries related to in-hospital falls. ... could have an unintended negative consequence. In trying to ... that hospitals might discourage patients from moving about at all. ...
... against a whole range of bacterial pathogens, have been ... drugs to treat viral diseases, on the other hand, ... led by Dr. Albrecht von Brunn of LMU Munich ... have identified a compound that inhibits the replication of ...
... than 1.5 billion overweight adults, including 400 million who are obese. ... women and 60 per cent of men are either overweight or ... weight loss, more than 80 per cent of obese dieters fail ... overweight or obese adults, with a BMI of between 27 and ...
... Trying to avoid eating the entire bag of candy bars ... that you won,t have the willpower to resist midnight raids ... be scary for your diet, according to Kara Smith, special ... several tips on how to limit empty Halloween calories, including: ...
Cached Medicine News:Health News:NYUCN receives $2.8 million NIH/NIAID grant to study combination HIV prevention for Kenyan youth 2Health News:Thyroid Surgery Linked to Improved Sleep Apnea Symptoms 2Health News:Study finds no link between elderly patient activity and hospital falls 2Health News:Novel strategy stymies SARS et al. 2Health News:Novel strategy stymies SARS et al. 3Health News:Obese people regain weight after dieting due to hormones 2
(Date:6/18/2013)... N.Y. , June 18, 2013  Millennium ... it has entered into an exclusive 25-year Supply ... regions with eWellness Corporation ("EWC") for its Distance ... easy to use physical therapy program is a ... and cardiovascular disease," said Chris Amandola , ...
(Date:6/18/2013)...  Cataracts are the leading cause of blindness in ... aging is the leading cause of eye diseases such ... 22 million Americans age 40 and older have cataracts, ... that number will increase over 30 million.  In a ... and computers, the demographic of ages 40 plus works ...
(Date:6/18/2013)... Calif. , June 18, 2013  Women are ... families, but unfortunately they often do not give the ... women have kept information from their doctor because they ... it, according to a recent survey conducted by Allergan ... organization dedicated to bringing education, funding and research to ...
Breaking Medicine Technology:Millennium HealthCare Signs Exclusive Distribution Agreement with eWellness Corporation for Northeast and Mid-Atlantic Regions 2Millennium HealthCare Signs Exclusive Distribution Agreement with eWellness Corporation for Northeast and Mid-Atlantic Regions 3New Vision Hope For Millions Undergoing Cataract Surgery 2New Vision Hope For Millions Undergoing Cataract Surgery 3New Survey Reveals One in Five Women Have Information They Keep Secret from their Doctors 2New Survey Reveals One in Five Women Have Information They Keep Secret from their Doctors 3New Survey Reveals One in Five Women Have Information They Keep Secret from their Doctors 4New Survey Reveals One in Five Women Have Information They Keep Secret from their Doctors 5New Survey Reveals One in Five Women Have Information They Keep Secret from their Doctors 6New Survey Reveals One in Five Women Have Information They Keep Secret from their Doctors 7New Survey Reveals One in Five Women Have Information They Keep Secret from their Doctors 8New Survey Reveals One in Five Women Have Information They Keep Secret from their Doctors 9
...   FHSSA counts its partnership initiative among its ... the Foundation for Hospices in Sub-Saharan Africa) has ... hospice programs and organizations providing care in 15 ... and friendship.  They are working collaboratively to expand ...
... TIANJIN, China, Oct. 27, 2011 /PRNewswire-Asia/ -- On October ... Centre" was co-founded at Teda by TEDA International Cardiovascular ... and BIOTRONIK (Beijing) SE & Co. KG of Germany. ... engages the professional medical staff for the online monitoring ...
Cached Medicine Technology:FHSSA Launches New Campaign to Partner US Hospices with Programs in Sub-Saharan Africa 2"TICH- BIOTRONIC Pacemaker Wireless Monitoring Services Centre" Founded 2"TICH- BIOTRONIC Pacemaker Wireless Monitoring Services Centre" Founded 3
... is a medical practice management ... tools and interfaces. This medical ... scheduling, patient demographics, insurance company ... paper and electronic claims filing ...
A.I.med's medical billing software is a medical billing software. The billing module integrates with A.I.med's Electronic Medical Record software. A.I.med's medical billing module also integrates wit...
... INTERACTANT is an integrated ... applications include general ledger, ... and comprehensive management reporting. ... are designed for multi-site, ...
... The Infinity Amylase CPNG3 single liquid ... the convenience of single liquid stability ... operator error and provide quick result ... the Infinity Amylase CPNG3 reagent provides ...
Medicine Products: