amfAR will release grants annually under the Krim Fellowship program. Recipients of 2008 Fellowships are:
Ivan DOrso, Ph.D./Mentor: Alan Frankel, Ph.D.
University of California, San Francisco, San Francsico, CA
HIV Tat-mediated transfer of P-TEFb to nascent RNA and its inhibition: In order to successfully reproduce, HIV must make full-length copies of its entire genome as well as copies of each of its genes. In order to ensure that full-length copies are made, the virus recruits a cell protein, P-TEFb, which interacts with a segment of the virus called Tat. Dr. DOrso plans to elucidate the precise details of the process whereby Tat and P-TEFb bind together and the structure of these protein complexes. Understanding the process of assembly and the shape taken by these proteins when they are bound together will help point towards potential therapies aimed at disrupting the vital relationship between the two proteins.
Felipe Diaz-Griffero, Ph.D./Mentor: Joseph Sodroksi, M.D.
Dana-Farber Cancer Institute, Inc., Boston, MA
Modulation of HIV-1 reverse transcription and integration by TRIM5: Successful infection requires that the virus undergo several transformations before inserting itself into the human DNA. Several proteins within human and animal cells can prevent HIV infection from occurring and are largely the reason most other animals cannot be infected with HIV. Dr. Diaz-Griffero plans to determine whether one such infection-blocking protein, TRIM5alpha from rhesus monkeys, ca
|Contact: Donald Kaplan|
amfAR, The Foundation for AIDS Research