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ACE inhibitors may increase risk of recurrence in breast cancer survivors
Date:4/20/2011

study were exposed to either a beta blocker or an ACE inhibitor. The women taking these drugs were generally older, post-menopausal and had other health issues, such as being overweight and having hypertension or diabetes.

In analyses that controlled for these differences in health issues, Ganz found that women exposed to ACE inhibitors had a significantly increased risk for recurrence, while those on beta blockers alone had a lower risk of recurrence. Exposure to both beta blockers and ACE inhibitors had an intermediate risk for recurrence, suggesting that the beta blockers might modify the increased risk associated with ACE inhibitor therapy.

"The ACE inhibitor findings were not expected. These observations need to be confirmed and suggest that greater attention should be focused on the potential effect of these commonly used medications on recurrence and breast cancer survival," Ganz said.

In addition, along with Jonsson Cancer Center researchers Steve Cole and Erica Sloan, Ganz is examining the effects of ACE inhibitors in the mouse model system to develop a better understanding of what is happening at the tissue level.

Ganz said that understanding the biology of stress and inflammation at the cellular level is critical, as healthy lifestyle behaviors such as exercise and stress reduction techniques also may influence the same biological pathways in the tumor microenvironment. Those strategies might also be employed to help prevent recurrence.

"There is an increasing interest in the relationship between host lifestyle factors and the outcomes of cancer treatment," the study states. "Behavioral factors, comorbid conditions and non-cancer-related pharmaceutical exposures may affect breast cancer outcomes."

Ganz currently is working with researchers in Denmark and Canada to examine these same medications and their relationship to recurrence in much larger samples of breast cancer patients. She hopes to confir
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Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles Health Sciences
Source:Eurekalert

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