Navigation Links
Zooming in on bacterial weapons in 3-D
Date:5/21/2012

This press release is available in German.

The plague, bacterial dysentery, and cholera have one thing in common: These dangerous diseases are caused by bacteria which infect their host using a sophisticated injection apparatus. Through needle-like structures, they release molecular agents into their host cell, thereby evading the immune response. Researchers at the Max Planck Institute for Biophysical Chemistry in Gttingen in cooperation with colleagues at the Max Planck Institute for Infection Biology in Berlin and the University of Washington in Seattle (USA) have now elucidated the structure of such a needle at atomic resolution. Their findings might contribute to drug tailoring and the development of strategies which specifically prevent the infection process.

Hundreds of tiny hollow needles sticking out of the bacterial membrane it is a treacherous tool that makes pathogens causing plague or cholera so dangerous. Together with a base, embedded in the membrane, these miniature syringes constitute the so-called type III secretion system an injection apparatus through which the pathogens introduce molecular agents into their host cell. There, these substances manipulate essential metabolic processes and disable the immune defines of the infected cells. The consequences are fatal as the pathogens can now spread within the organism without hindrance. To date, traditional antibiotics are prescribed to fight the infection. However, as some bacterial strains succeed in developing resistances, researchers worldwide seek to discover more specific drugs.

The exact structure of the 60 to 80 nanometre (60 to 80 millionths of a millimetre) long and about eight nanometre wide needles has so far been unknown. Classical methods such as X-ray crystallography or electron microscopy failed or yielded wrong model structures. Not crystallisable and inso
'/>"/>

Contact: Dr. Adam Lange
adla@nmr.mpibpc.mpg.de
49-551-201-2214
Max-Planck-Gesellschaft
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Fish Pedicure a Recipe for Bacterial Infection, Researchers Warn
2. University of Minnesota startup to treat challenging bacterial infection
3. Children with juvenile arthritis have higher rates of bacterial infection
4. Pharmacy Robots Linked to Bacterial Contamination of Drugs
5. Jefferson researchers mirror human response to bacterial infection and resolution in mice
6. Bacterial Strain Behind Black Death Plague Is Likely Extinct: Study
7. CDC Report Shows Bacterial Meningitis Cases on the Decline
8. Get a whiff of this: Low-cost sensor can diagnose bacterial infections
9. Antibacterial Soap Additive Accumulates in Fish: Study
10. Novel approaches to bacterial caries management: An efficacious solution in view?
11. Use of alcohol-free antibacterial mouth-rinse is associated with decrease in preterm birth
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Zooming in on bacterial weapons in 3-D
(Date:7/12/2014)... The report, "Phthalic Anhydride and Derivatives ... Application & Geography – Trends & Forecast to 2018," ... forecasting of market volume and value. The report also ... The market of phthalic anhydride is projected to grow ... million by 2018, with a CAGR of 5.24% from ...
(Date:7/12/2014)... In this cognitive assessment ... and training’ is defined as solution that ... enhance cognitive functions. These solutions are applied ... screening, clinical trials, driver’s safety, rehabilitation, academic ... brain training, and employers’ assessment and training ...
(Date:7/12/2014)... 2014 The fastest-growing mobile technology is ... measurement of LTE networks continues to grow due to ... devices have increased mobile data traffic, which is a ... market. Communications Test and Measurement equipment comply with industry ... Communications Test and Measurement Market is estimated to grown ...
(Date:7/12/2014)... News) -- If you make exercise fun, you,ll eat less ... 56 adults were led on a 1.4-mile walk and were ... scenic walk. The participants were given lunch after the walk, ... ate 35 percent more chocolate pudding for dessert than those ... another experiment, 46 adults were given mid-afternoon snacks after their ...
(Date:7/12/2014)... ON Canada (PRWEB) July 12, 2014 Sean Francis, ... for throwing out special challenges to his clients. He’s also known ... Club. He recently found a way to combine the two and ... has raised $2,000 for the Boys and Girls Club. , The ... Program, which started on June 23rd. Francis sent out emails and ...
Breaking Medicine News(10 mins):Health News:Phthalic Anhydride Market Projected to Reach $8.42 Billion by 2018 – Report by MarketsandMarkets 2Health News:Phthalic Anhydride Market Projected to Reach $8.42 Billion by 2018 – Report by MarketsandMarkets 3Health News:Phthalic Anhydride Market Projected to Reach $8.42 Billion by 2018 – Report by MarketsandMarkets 4Health News:Global Cognitive Assessment & Training Market: 27.3% CAGR to 2018 Says a New Research Report Available at LifeScienceIndustryResearch.com 2Health News:Global Cognitive Assessment & Training Market: 27.3% CAGR to 2018 Says a New Research Report Available at LifeScienceIndustryResearch.com 3Health News:Global Cognitive Assessment & Training Market: 27.3% CAGR to 2018 Says a New Research Report Available at LifeScienceIndustryResearch.com 4Health News:Global Cognitive Assessment & Training Market: 27.3% CAGR to 2018 Says a New Research Report Available at LifeScienceIndustryResearch.com 5Health News:North America Communication Test and Measurement (CT&M) Market Worth $1.9 Billion by 2018 - New Report by MicroMarket Monitor 2Health News:North America Communication Test and Measurement (CT&M) Market Worth $1.9 Billion by 2018 - New Report by MicroMarket Monitor 3Health News:North America Communication Test and Measurement (CT&M) Market Worth $1.9 Billion by 2018 - New Report by MicroMarket Monitor 4Health News:North America Communication Test and Measurement (CT&M) Market Worth $1.9 Billion by 2018 - New Report by MicroMarket Monitor 5Health News:Make Exercise Fun, Eat Less Afterwards 2Health News:Kawartha Lakes Fit Body Boot Camp’s Successful Fat Loss Challenge Results in $2,000 to Boys and Girls Club 2Health News:Kawartha Lakes Fit Body Boot Camp’s Successful Fat Loss Challenge Results in $2,000 to Boys and Girls Club 3
... ... ... ... ...
... ... , ... , , , ... NEW YORK , March 4 ...
... ... ... ... ...
... third leading cause of cancer death among men and ... CRC screening receive it. The American Gastroenterological Association (AGA) ... of screening and to encourage everyone age 50 and ... that those without insurance have limited access to screening, ...
... Calculus Bovis compound preparation (ICCBco) in the treatment ... schistosomiasis as the experimental animal model, a research ... trial to observe pathological changes and pathological effect ... the lung tissue of portal hypertensive rabbits with ...
... at risk, but elderly women are too, study finds , ... common cause of shoulder dislocation, and young males have the ... study shows. , Researchers studied 8,940 shoulder dislocations treated at ... to 2006 and found that the overall incidence rate was ...
Cached Medicine News:Health News:'Less Is More' with the Innovation of Avemar(R) Fermented Wheat Germ Extract 2Health News:'Less Is More' with the Innovation of Avemar(R) Fermented Wheat Germ Extract 3Health News:'Less Is More' with the Innovation of Avemar(R) Fermented Wheat Germ Extract 4Health News:'Less Is More' with the Innovation of Avemar(R) Fermented Wheat Germ Extract 5Health News:Cowen Group Announces Promotions in Health Care Investment Banking 2Health News:Cowen Group Announces Promotions in Health Care Investment Banking 3Health News:Alan Henry, M.D. Joins MedSolutions as Chief Medical Officer of Premerus 2Health News:Alan Henry, M.D. Joins MedSolutions as Chief Medical Officer of Premerus 3Health News:Alan Henry, M.D. Joins MedSolutions as Chief Medical Officer of Premerus 4Health News:Alan Henry, M.D. Joins MedSolutions as Chief Medical Officer of Premerus 5Health News:Alan Henry, M.D. Joins MedSolutions as Chief Medical Officer of Premerus 6Health News:Physicians come together on National Colorectal Cancer Awareness and Screening Day 2Health News:Treatment of portal hypertensive pulmonary lesions induced by schistosomiasis 2Health News:Shoulder Dislocations a Sports Hazard 2
(Date:7/11/2014)... SAN DIEGO , July 11, 2014 ... Therapies Corp. ("Biotie") to end the option held by ... to commence further development of NRL-1 (intranasal diazepam) for ... seizures. Over the past year, Biotie has ... Neurelis in preparation for the pivotal clinical work required ...
(Date:7/10/2014)... 10, 2014 Integrated Silicon Solution, Inc. (Nasdaq: ... and analog IC solutions, today announced that it will ... 2014, at 7:00 a.m. Pacific Time (10:00 a.m. Eastern ... fiscal 2014 third quarter ended June 30, 2014. ... 1-888-556-4997 before 6:50 a.m. Pacific time on July 24, ...
(Date:7/10/2014)... , July 10, 2014   Ventana Medical ... today announced it has entered into an agreement with ... operates as EMD Serono in the United ... to collaborate with Merck KGaA,s biopharmaceutical division on the ... an undisclosed target using Ventana,s proprietary diagnostic assays. In ...
Breaking Medicine Technology:Neurelis Regains Rights to Intranasal Diazepam Program 2Neurelis Regains Rights to Intranasal Diazepam Program 3Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 3
... breakthrough in specimen radiography. The XPERT represents a ... shades of gray in every digital x-ray image, ... in density that heretofore were lost to the ... 2 x 2 to 8 x 8 in ...
The Triage Profiler Shortness of Breath Panel provides rapid risk assessment and differential diagnosis of patients presenting to the emergency department with shortness of breath and risk assessment...
... The 6303 is an affordable ... provide full height, seat, and back ... 6303 accepts the full line of ... the perfect table for your needs; ...
... Sonesta 6202 is the ultimate ... our most popular accessories, the ... a myriad of exam and ... quiet) motors allow fast & ...
Medicine Products: