Navigation Links
Zoloft, Lexapro the Best of Newer Antidepressants
Date:1/29/2009

Review looked at 12 drugs, 117 studies and 25,000 patients to arrive at ranking

THURSDAY, Jan. 29 (HealthDay News) -- Sertraline (Zoloft) and escitalopram (Lexapro) are the best of 12 new-generation antidepressants, while reboxetine is the least effective, a new analysis shows.

The Italian researchers reviewed 117 studies that included more than 25,000 patients with major depression to come to this conclusion.

The drugs tested in the trials were bupropion (Wellbutrin/Zyban), citalopram (Celexa), duloxetine (Cymbalta), escitalopram, fluoxetine (Prozac), fluvoxamine (Luvox), milnacipran (Savella), mirtazapine (Remeron), paroxetine (Paxil), reboxetine (Edronax/Vestra), sertraline, and venlafaxine (Effexor).

Based on their analysis, the review authors concluded sertraline and escitalopram were the best antidepressants overall in terms of efficacy and patient acceptability. Sertraline was found to be more effective than duloxetine by 30 percent, fluvoxamine (27 percent), fluoxetine (25 percent), paroxetine (25 percent), and reboxetine (85 percent). Escitalopram was more effective than duloxetine by 33 percent, fluoxetine (32 percent), fluvoxamine (35 percent), paroxetine (30 percent), and reboxetine (95 percent).

Mirtzapine and venlafaxine were as effective as sertraline and escitalopram. But the latter two drugs had the best patient acceptability, which meant significantly fewer patients stopped treatment.

The review was published online Jan. 29 and was expected to be published in an upcoming print issue of The Lancet.

"The most important clinical implication of the results is that escitalopram and sertraline might be the best choice when starting a treatment for moderate to severe major depression, because they have the best possible balance between efficacy and acceptability," Dr. Andrea Cipriani, of the University of Verona in Italy, and colleagues said in a news release from the journal.

"Sertraline seems to be better than escitalopram because of its lower cost in most countries. However, in the absence of a full economic model, this recommendation cannot be made unequivocally, because several other costs are associated with the use of antidepressants," they added.

More information

The U.S. Agency for Healthcare Research and Quality has more about antidepressants.



-- Robert Preidt



SOURCE: The Lancet, news release, Jan. 29, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Caraco Pharmaceutical Laboratories, Ltd. Announces Tentative FDA Approval for Generic Lexapro(R)
2. Newer Contraceptives Dont Increase Heart Risk
3. Newer Antipsychotics Pose Cardiac Risk: Study
4. Most Newer Antipsychotics No Better Than Older Ones, Just Different
5. Newer antipsychotics no better than older drug in treating child and adolescent schizophrenia
6. First generation antipsychotic drugs as effective as newer ones in some children
7. Newer Blood Pressure Drug Better for Some Heart Patients, Diabetics
8. Newer Blood Pressure Drug No Better Than Placebo in Preventing Stroke
9. Newer Prostate Cancer Treatment Similar to Traditional Surgery
10. Newer Rheumatoid Arthritis Drugs Lower Production of B Cells
11. Newer Sedative Might Help Patients on Ventilators
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Zoloft, Lexapro the Best of Newer Antidepressants
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) of Somerset ... of specialty vendors and unique items from across the nation, this holiday-themed event will ... services offered by the VNA. The boutique will be open Saturday, November 4 ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader ... been awarded a contract by the Center for Medicare and Medicaid Services (CMS). ... the enterprise use of Agile methodologies in a consistent and high value manner ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the ... today its plans to open a flagship location in Covington, LA at 401 N. ... To Go store next to Office Depot in the Holiday Square shopping center. Its ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... delivery system that we intend to develop to enable prevention of a major ... to severe hearing loss, especially in pediatric patients. For cisplatin, hearing loss is ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... of Michigan’s 2017 Best and Brightest in Wellness® by Best and Brightest. OnSite ... program on Friday, Oct. 20 from 7:30 a.m. to 2 p.m. at the ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... -- Eli Lilly and Company (NYSE: LLY ) ... of 2017 on Tuesday, October 24, 2017. Lilly will ... the investment community and media to further detail the ... begin at 9 a.m. Eastern time. Investors, media and ... the conference call through a link that will be ...
(Date:9/28/2017)... , Sept. 28, 2017 Hill-Rom Holdings, Inc. ... earnings conference call and webcast on Friday, November 3, ... (EDT) and ending at approximately 8:30 a.m. (CDT) / ... the company,s 2017 financial performance and guidance for 2018, ... initiatives to enhance operational performance, and long-range financial outlook ...
(Date:9/25/2017)... 25, 2017   Montrium , an industry ... today—from the IQPC Trial Master Files & Inspection ... that EastHORN Clinical Services has selected eTMF ... TMF management. EastHORN, a leading European contract research ... increase transparency to enable greater collaboration with sponsors, ...
Breaking Medicine Technology: