Navigation Links
Zoloft, Lexapro the Best of Newer Antidepressants

Review looked at 12 drugs, 117 studies and 25,000 patients to arrive at ranking

THURSDAY, Jan. 29 (HealthDay News) -- Sertraline (Zoloft) and escitalopram (Lexapro) are the best of 12 new-generation antidepressants, while reboxetine is the least effective, a new analysis shows.

The Italian researchers reviewed 117 studies that included more than 25,000 patients with major depression to come to this conclusion.

The drugs tested in the trials were bupropion (Wellbutrin/Zyban), citalopram (Celexa), duloxetine (Cymbalta), escitalopram, fluoxetine (Prozac), fluvoxamine (Luvox), milnacipran (Savella), mirtazapine (Remeron), paroxetine (Paxil), reboxetine (Edronax/Vestra), sertraline, and venlafaxine (Effexor).

Based on their analysis, the review authors concluded sertraline and escitalopram were the best antidepressants overall in terms of efficacy and patient acceptability. Sertraline was found to be more effective than duloxetine by 30 percent, fluvoxamine (27 percent), fluoxetine (25 percent), paroxetine (25 percent), and reboxetine (85 percent). Escitalopram was more effective than duloxetine by 33 percent, fluoxetine (32 percent), fluvoxamine (35 percent), paroxetine (30 percent), and reboxetine (95 percent).

Mirtzapine and venlafaxine were as effective as sertraline and escitalopram. But the latter two drugs had the best patient acceptability, which meant significantly fewer patients stopped treatment.

The review was published online Jan. 29 and was expected to be published in an upcoming print issue of The Lancet.

"The most important clinical implication of the results is that escitalopram and sertraline might be the best choice when starting a treatment for moderate to severe major depression, because they have the best possible balance between efficacy and acceptability," Dr. Andrea Cipriani, of the University of Verona in Italy, and colleagues said in a news release from the journal.

"Sertraline seems to be better than escitalopram because of its lower cost in most countries. However, in the absence of a full economic model, this recommendation cannot be made unequivocally, because several other costs are associated with the use of antidepressants," they added.

More information

The U.S. Agency for Healthcare Research and Quality has more about antidepressants.

-- Robert Preidt

SOURCE: The Lancet, news release, Jan. 29, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Caraco Pharmaceutical Laboratories, Ltd. Announces Tentative FDA Approval for Generic Lexapro(R)
2. Newer Contraceptives Dont Increase Heart Risk
3. Newer Antipsychotics Pose Cardiac Risk: Study
4. Most Newer Antipsychotics No Better Than Older Ones, Just Different
5. Newer antipsychotics no better than older drug in treating child and adolescent schizophrenia
6. First generation antipsychotic drugs as effective as newer ones in some children
7. Newer Blood Pressure Drug Better for Some Heart Patients, Diabetics
8. Newer Blood Pressure Drug No Better Than Placebo in Preventing Stroke
9. Newer Prostate Cancer Treatment Similar to Traditional Surgery
10. Newer Rheumatoid Arthritis Drugs Lower Production of B Cells
11. Newer Sedative Might Help Patients on Ventilators
Post Your Comments:
Related Image:
Zoloft, Lexapro the Best of Newer Antidepressants
(Date:10/13/2015)... ... 2015 , ... Sir Grout of Greater Boston donated an expansive, seven room ... McDonald House Charities® (RMHC®). This donation was made in an effort to give back ... its inception. , “We believe strongly in the Ronald McDonald House Charities, and they ...
(Date:10/13/2015)... Diego, CA (PRWEB) , ... October 13, 2015 ... ... launch of its newest technology platform, ENGAGE, at HIMSS’s Patient Engagement Summit ... to end. , ENGAGE delivers innovative health programs and interventions via mobile devices ...
(Date:10/13/2015)... ... 2015 , ... Element Blue ™, a leading IT ... RightSensor™ LLC, an Internet of Things (IoT) hardware supplier that delivers custom and ... for customers requiring sensor hardware for critical data environments. , RightSensor™, working with ...
(Date:10/13/2015)... ... October 13, 2015 , ... NavaFit Inc. today announced the launch of its ... with, participate in local fitness & sporting events, and stay motivated. Users ... medical costs drive us to get more serious about fitness and wellness, individuals are ...
(Date:10/13/2015)... (PRWEB) , ... October 13, ... ... Postnatal Omega-3, a first-of-its kind product that targets the unique health needs ... Omega-3” of the American Pregnancy Association ( ), utilizes Nordic Naturals’ ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... SAN FRANCISCO , October 13, 2015 ... it will be sharing additional findings from the multicenter ... Therapeutics (TCT) meeting in San Francisco ... Device , announced that it will be sharing additional ... community at the Trans-Catheter Therapeutics (TCT) meeting in ...
(Date:10/13/2015)... , Oct. 13, 2015  The spine division of ... in musculoskeletal healthcare, will showcase its portfolio of innovative ... Society (NASS) annual meeting, October 14-17, 2015, in ... host two clinical events: "Supplemental MIS Fixation ... Wednesday, October 14 12:30 – 1 p.m. --> ...
(Date:10/13/2015)... , Oct. 13, 2015  Human Longevity, Inc. (HLI), ... of medicine, announced today the launch of the company,s ... that has the potential to transform healthcare. The inaugural ... CA , at HLI,s headquarters facility. More Health ... other US and International cities. ...
Breaking Medicine Technology: