Navigation Links
Zebrafish provide useful screening tool for genes, drugs that protect against hearing loss
Date:2/29/2008

ovement of fluid (triggered by sound vibrations in the inner ear or changes in water pressure in the fishs environment) causes the stereocilia to tilt to one side, generating an electrical impulse that travels to the brain.

The researchers first set out to identify genes that may be involved in how hair cells respond to ototoxic medicines. Using a chemical that causes random mutations in zebrafish, the researchers bred various fish families, with each family exhibiting a different set of mutations. The researchers then exposed five-day-old larval offspring to the drug neomycin, a type of antibiotic that damages these hair cells as well as those in the human inner ear. The larvae were then stained to determine if the hair cells were still intact. Fish that were resistant to damage were quickly identified as were those that were especially vulnerable.

Using genetic techniques, the group then examined the larvaes DNA, searching for segments that were closely tied to the desired property. In doing so, they zoomed in on five mutationseach located on different genesthat, when inherited from each parent, protected against hair cell damage. Further examination revealed that one of the identified genes corresponds to a gene that is also found in other vertebrates, including humans. Another five mutations were identified that offer protection under more complex genetic conditions.

Next, the team investigated whether they could identify chemical compounds that protect hair cells against ototoxic medicines. Using the same screening techniqueexposing five-day-old zebrafish larvae to neomycin and later applying special stains to the hair cellsthe researchers screened more than 10,000 compounds and narrowed them down to two similar chemicals that provide robust protection of hair cells against the neomycin. One of the compounds was later found to protect hair cells from a mouses inner ear against the drug, indicating that the same compound may be prot
'/>"/>

Contact: Jennifer Wenger
jwenger@mail.nih.gov
301-496-7243
NIH/National Institute on Deafness and Other Communication Disorders
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Phylonix granted broad European patent for transplanting human cells into zebrafish
2. Transparent zebrafish help researchers track breast cancer
3. NIH awards Phylonix phase II SBIR to develop zebrafish models for eye diseases
4. Microbiotic technology developed for microinjection of zebrafish embryos
5. Johnson & Johnson Diabetes Institute, LLC Launches New Center to Provide State-of-the-Art Education, Training to Health Professionals
6. Crdentia Selected by Leading Staffing Vendor to Provide Health Care Staffing Services to One of the Largest Hospital Chains in the U.S.
7. Hooper Holmes to Provide Business Update
8. XCPT(TM) Patient Engagement and Communication Software and DentalXP.com, a Leading Provider of Online Dental Education and Content, Sign a Co-Marketing Agreement
9. AMN Healthcare Reports Fourth Quarter and Year End 2007 Results; Provides Full Year 2008 Guidance
10. HASP Online Provides Free Job Safety Analysis Tool Available Online
11. Microsoft to Showcase Innovative Solutions for Healthcare Providers and Consumers at HIMSS 2008 Annual Conference & Exhibition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... active in almost all types of cancer sends the ... help fuel a tumour,s uncontrolled growth, new research suggests. ... identified a molecular trigger responsible for ratcheting up activity ... that makes the building blocks cancer cells need to ... pathway, called SREBP, controls the flow of messages to ...
(Date:7/9/2014)... most common type of lung cancer, researchers have uncovered ... in forming tumors. The new knowledge may expand treatments ... changes already are available or are in clinical trials. ... from The Cancer Genome Atlas (TCGA), including researchers at ... Medical School and other institutions, studied tumors from 230 ...
(Date:7/9/2014)... a relatively optimistic picture of women,s chances of surviving ... the chest wall or skin, but not beyond. ... size and whether they have involved lymph nodes, are ... advanced" tumors, suggesting that they are a relatively serious ... breast cancers of this and other types account for ...
(Date:7/9/2014)... drug users in Russia might contribute to HIV ... conducted by researchers from Boston University Schools of ... Petersburg Pavlov State University, sought to discover the ... of a cohort of HIV-positive people with lifetime ... arrested by police were more likely to share ...
(Date:7/9/2014)... Although feelings are personal and subjective, the ... that objectively represents emotions across different senses, situations ... Cornell University neuroscientist Adam Anderson. , "We discovered ... orbitofrontal cortex, an area of the brain associated ... which captures an individual,s subjective feeling," says Anderson, ...
Breaking Medicine News(10 mins):Health News:Signal may send cancer's cellular factories into overdrive 2Health News:Lung cancer study hints at new treatments 2Health News:Fox Chase researchers recommend updating the staging criteria for breast cancer diagnoses 2Health News:Fox Chase researchers recommend updating the staging criteria for breast cancer diagnoses 3Health News:BU researchers relate arrests with HIV risk environment 2Health News:Study cracks how the brain processes emotions 2
... that post-menopausal women who gain weight in adulthood are at ... irrespective of whether they are on hormone replacement therapy (HRT). ... have explored the relationship between breast cancer types and weight ... publication of the American Cancer Society. ,The effect ...
... officials in Tripura have announced that, they are taking preventive ... malaria from the past three months//. ,A ... also scheduled to visit Tripura to assess the situation and ... resistance. He also stated that almost 200 teams, consisting ...
... many youth under a spell. Recent figures have revealed the ... an increase of 400%, ever since the labour has come ... specialized services to remedy this menace, among children. Neil McKeganey, ... said: "These figures are shocking and they underline the reason ...
... is witness to an International Aids Candlelight Memorial which is ... very much a domestic problem and disassociating from it is ... estimated that nearly 2700 New Zealanders are suffering HIV. The ... people who had died of AIDS. But this time, it ...
... to end the medicos stir, the government has issued ... senior faculty members// who are supporting them. ... vacate hostels if they fail to return to work," ... step was taken after government issued advertisements for recruiting ...
... havoc with health, a new study has found that more ... suffers// from metabolic syndrome, a condition which predisposes people to ... per cent of the people in the age group of ... signified by combination of factors like high blood pressure, high ...
Cached Medicine News:Health News:Obese Women At Increased Risk Of Developing Breast Cancer 2Health News:Striking Students Asked to Vacate Hostels 2
(Date:1/15/2014)... MultiCell Technologies, Inc. (OTC Bulletin Board: MCET.OB ... composition of matter, biological targets, mechanism of action, methods ... This patent application describes a novel class ... which interfere with the basic homeostatic cellular processes in ...
(Date:1/15/2014)... Jan. 15, 2014  According to Millennium Research Group ... intelligence, the United States ... markets will expand moderately through 2022, with embolization ... particular, increasing interest in drug-eluting beads (DEBs) and ...
(Date:1/15/2014)... 2014  Valeant Pharmaceuticals International, Inc. (NYSE: VRX ... period under the Hart-Scott-Rodino Antitrust Improvements Act of 1976 ... by its indirect wholly-owned subsidiary, Sapphire Subsidiary Corp. ("Purchaser"), ... of Solta Medical, Inc. (NASDAQ: SLTM ) ...
Breaking Medicine Technology:MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 3US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 2US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 3Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 2Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 3
... the heart of the Espion2 Electrophysiology system. ... aluminum chassis, real-time DSP, USB control, an ... differential amplifiers. The E2 connects to any ... over standard wi-fi Ethernet. The E2 includes ...
... breakthrough in visual field testing that's so ... FDT, the first visual field instrument that's ... to be used even in pre-test. Affordably ... clinical trials behind it to validate performance. ...
... Automatic Perimeter, a compact version of ... reputation, provides an accurate visual field ... and has function required for visual,field ... visual field very quickly. It ...
... AAA Endoprosthesis is an innovative device designed ... for patients with abdominal aortic aneurysms (AAA). ... bifurcated graft with an outer self-expanding Nitinol ... and material durability. The function of the ...
Medicine Products: