Navigation Links
Zebrafish popular with researchers
Date:1/26/2011

TORONTO, Ont.-- Zebrafish are the new fruit flies.

And it's not just because they breed like rabbits.

Generations of high school students learned about genetics and developmental biology by breeding and studying fruit flies (Drosophila melanogaster).

Fruit flies were also one of the most important research animals because they reproduce quickly and, well, fruitfully; they don't require much love and attention; and they share many genes and proteins with humans.

Now there's a new kid in town: The zebrafish is becoming increasingly popular among researchers, such as Dr. Xiao-Yan Wen.

Wen already has more than 1,000 zebrafish in his state-of-the-art lab where he and others perform chemical genetic screens in which chemicals or drugs from a large library of compounds are tested for their effects on early zebrafish development. Because the tests are carried out on a complete, developing organisma vertebrate in this case--researchers get more detailed and complex information about the impact of the chemical than if they were testing them on cell cultures.

Wen is director of St. Michael's Zebrafish Facility and its Zebrafish Centre for Advanced Drug Discovery.

Zebrafish produce lots of eggs a healthy mating pair can produce 100 to 200 a week. Fertilization and development occur externally, so researchers can directly observe and manipulate the embryoes. Plus, they are transparent, so researchers can see what's going on, or inject them with fluorescent dye.

Wen's primary focus has been cardiovascular disease, the country's top public health threat. Wen's team has already identified one drug, rosuvastatina cholesterol-lowering statin sold as Crestor by AstraZenecathat suppressed the growth of transplanted human prostate cancer cells in mice. That research appeared in the September 2010 issue of the journal European Urology.

However, this screening process is labor-intensive. It takes one experienced technician about three months to screen 1,000 compounds in zebrafish embryoes. Wen's team has received $2 million from the Canada Foundation for Innovation to build the Zebrafish Centre for Advanced Drug Discovery, which would be the first automated high-throughput zebrafish screening facility in Canada and one of the most advanced screening facilities in the world.


'/>"/>

Contact: Leslie Shepherd
shepherdl@smh.ca
416-864-6094
St. Michael's Hospital
Source:Eurekalert

Related medicine news :

1. EMBL picture release: Developing zebrafish patchwork
2. Tanning Beds Still Popular Despite Skin Cancer Risk
3. Popular Mechanics breakthrough awardees announced
4. Popular prostate cancer treatment associated with bone decay
5. New guideline finds no evidence for a popular back procedure
6. Expert Panel Links Popular Bone Drugs to Rare Fracture
7. Popular diabetes drugs associated with fractures in type 2 diabetic patients
8. New research finds no evidence that popular slimming supplements facilitate weight loss
9. Iceland -- Working on its Popularity for Travellers, Iceland ProTravel Supports Ad Campaign "Inspired by Iceland"
10. SDI Reports: Roughly Half of Patients Prescribed the Most Popular Osteoporosis Drugs Discontinue Therapy Within 6 Months -- Amgen's Prolia Offers New Dosing Option
11. New iPhone App “Wing Chun Masters” Brings 400-Year-Old Kung Fu To Life Amidst Renewed Popular Interest In Culture.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading ... to advocate for action towards gender equality at their inaugural Summit in New York ... globe, and reached a social audience of over 3 million. To watch the Mobilize ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... giving viewers the lowdown on sciatica in a new episode of "Success Files," ... on current events and innovation and investigates each subject in-depth with passion and ...
(Date:10/13/2017)... ... ... “America On The Brink”: the Christian history of the United States and the loss ... author, William Nowers. Captain Nowers and his wife, Millie, have six children, ten ... the Navy. Following his career as a naval aviator and carrier pilot, he ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
(Date:10/12/2017)... ... , ... The American College of Medical Informatics (ACMI) will present the 2017 ... Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium is ... pioneer in the field of medical informatics, this prestigious award is presented to an ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... 2017  BioPharmX Corporation (NYSE MKT: BPMX) researchers were ... innovative way to use nonlinear optical imaging to confirm ... drugs. A ... show how researchers from BioPharmX and the Wellman Center ... a suite of imaging techniques in what is called ...
(Date:10/10/2017)... COUNTY, Calif. , Oct. 10, 2017  NDS received FDA ... Mobile  — a medical-grade battery-powered display stand specifically designed for endoscopy ... to transform technology into a clinical solution to support the improvement ... Innovative Design ... ZeroWire Mobile Wireless Solution ...
(Date:10/4/2017)... SEOUL, South Korea , Oct. 4, 2017 /PRNewswire/ ... launched its next-generation CPR training aide "cprCUBE" on Kickstarter. ... of chest compression during cardiac arrests with better efficiency ... patient-mannequins. It also offers real-time feedback on efficacy of ... The crowdfunding campaign has a goal to raise ...
Breaking Medicine Technology: