Navigation Links
Zebrafish popular with researchers
Date:1/26/2011

TORONTO, Ont.-- Zebrafish are the new fruit flies.

And it's not just because they breed like rabbits.

Generations of high school students learned about genetics and developmental biology by breeding and studying fruit flies (Drosophila melanogaster).

Fruit flies were also one of the most important research animals because they reproduce quickly and, well, fruitfully; they don't require much love and attention; and they share many genes and proteins with humans.

Now there's a new kid in town: The zebrafish is becoming increasingly popular among researchers, such as Dr. Xiao-Yan Wen.

Wen already has more than 1,000 zebrafish in his state-of-the-art lab where he and others perform chemical genetic screens in which chemicals or drugs from a large library of compounds are tested for their effects on early zebrafish development. Because the tests are carried out on a complete, developing organisma vertebrate in this case--researchers get more detailed and complex information about the impact of the chemical than if they were testing them on cell cultures.

Wen is director of St. Michael's Zebrafish Facility and its Zebrafish Centre for Advanced Drug Discovery.

Zebrafish produce lots of eggs a healthy mating pair can produce 100 to 200 a week. Fertilization and development occur externally, so researchers can directly observe and manipulate the embryoes. Plus, they are transparent, so researchers can see what's going on, or inject them with fluorescent dye.

Wen's primary focus has been cardiovascular disease, the country's top public health threat. Wen's team has already identified one drug, rosuvastatina cholesterol-lowering statin sold as Crestor by AstraZenecathat suppressed the growth of transplanted human prostate cancer cells in mice. That research appeared in the September 2010 issue of the journal European Urology.

However, this screening process is labor-intensive. It takes one experienced technician about three months to screen 1,000 compounds in zebrafish embryoes. Wen's team has received $2 million from the Canada Foundation for Innovation to build the Zebrafish Centre for Advanced Drug Discovery, which would be the first automated high-throughput zebrafish screening facility in Canada and one of the most advanced screening facilities in the world.


'/>"/>

Contact: Leslie Shepherd
shepherdl@smh.ca
416-864-6094
St. Michael's Hospital
Source:Eurekalert

Related medicine news :

1. EMBL picture release: Developing zebrafish patchwork
2. Tanning Beds Still Popular Despite Skin Cancer Risk
3. Popular Mechanics breakthrough awardees announced
4. Popular prostate cancer treatment associated with bone decay
5. New guideline finds no evidence for a popular back procedure
6. Expert Panel Links Popular Bone Drugs to Rare Fracture
7. Popular diabetes drugs associated with fractures in type 2 diabetic patients
8. New research finds no evidence that popular slimming supplements facilitate weight loss
9. Iceland -- Working on its Popularity for Travellers, Iceland ProTravel Supports Ad Campaign "Inspired by Iceland"
10. SDI Reports: Roughly Half of Patients Prescribed the Most Popular Osteoporosis Drugs Discontinue Therapy Within 6 Months -- Amgen's Prolia Offers New Dosing Option
11. New iPhone App “Wing Chun Masters” Brings 400-Year-Old Kung Fu To Life Amidst Renewed Popular Interest In Culture.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2017)... ... 2017 , ... Houston dentist , Dr. Behzad Nazari, ... Center. Currently, patients can get single dental implants for $3,599 and All On ... more about these offers by contacting Antoine Dental Center. Both of these options ...
(Date:2/24/2017)... , ... February 24, 2017 , ... The Smart Machine ... from Oxford University predict that 47 percent of all jobs in the United States ... “smart” and “successful.” The day of the aggressive know-it-all who steamrolls over colleagues is ...
(Date:2/24/2017)... ... February 24, 2017 , ... With ProGlass Prism users now have the ... have total control over position, rotation, distortion, edge softness, edge blur, chromatic aberration, individual ... X. , With ProGlass Prism users are given the tools and effects to ...
(Date:2/24/2017)... ... February 24, 2017 , ... The Radiology Business Management Association will ... at the annual Building Better Radiology Marketing Programs conference, held this year ... Worth, Texas. Nine awards are given out in five categories. They are:, ...
(Date:2/23/2017)... MA (PRWEB) , ... February 23, 2017 , ... ... and Department of Justice jointly issued a letter to withdraw previous ... accordance with their gender identity. The guidance issued in May 2016 by the ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... and Markets has announced the addition of the "Dry eye Drugs ... ... Drugs Price Analysis and Strategies - 2016, provides drug pricing data and ... following questions: What are the key drugs ... in the Global Dry eye market? What are the ...
(Date:2/24/2017)... CHAPEL HILL, N.C. , Feb. 24, 2017 ... sector are exploring ways to increase their self-service ... as Health Care Providers (HCPs). New ... that many pharma organizations have developed self-service website ... questions electronically.  This is just one of many ...
(Date:2/24/2017)... 2017 Report analyzes the worldwide markets for Endodontic ... for the US, Canada , ... Asia-Pacific , Latin America , and ... the period 2015 through 2022. Also, a six-year historic analysis ... derived from primary and secondary research. Company profiles are primarily ...
Breaking Medicine Technology: