Navigation Links
Zebrafish offer clues to treatments for motor neurone disease
Date:4/29/2009

Tiny zebrafish could hold the key to stem cell treatments for motor neurone disease.

Scientists at the University of Edinburgh have found that these fish are able to produce motor neurones cells that control all muscle activity such as speaking, walking and breathing in humans when they repair damage to their spinal cords.

Researchers are now screening small molecules with a view to finding drugs that could kick-start the process of motor neurone regeneration in zebrafish, with a view to translating their findings into treatments for humans.

The discovery could help patients with motor neurone disease, in which the motor neurone cells die and are not replaced. This disease can cause paralysis and severe breathing difficulties and is an ultimately fatal condition for which no cure exists.

Dr Catherina Becker, from the University of Edinburgh's Centre for Neuroregeneration and Euan MacDonald Centre for Motor Neurone Disease Research, said: "Understanding how zebrafish can regenerate large numbers of motor neurones after damage to the spinal cord and how these motor neurones are produced by natural stem cells could help in finding treatments for Motor Neurone Disease.

"This could take the form of improving methods of generating motor neurones in the laboratory that could be transplanted or finding drugs which could help patients renew their motor neurone supply."

The tropical zebrafish, which are transparent and around 3 cm long, produce the motor neurones from progenitor cells found in the spinal cord that are able to turn into certain types of cells.

As well as looking at stimulating the production of motor neurones, scientists are working on ways to ensure that these cells are able to function by sending messages from the brain to the spine and then on to muscles. The research could also have implications for treating spinal cord injuries following accidents.

The research team is the first to benefit from the Edinburgh BioQuarter commercialisation initiative, funded by the University of Edinburgh and Scottish Enterprise, to assist translating research into therapies. Researchers have also received a joint grant from the Robert Packard Center in Baltimore and Euan MacDonald Centre in Edinburgh, which specialise in research into amyotrophic lateral sclerosis (ALS), the most common form of Motor Neurone Disease.


'/>"/>

Contact: Tara Womersley
tara.womersley@ed.ac.uk
01-316-509-836
University of Edinburgh
Source:Eurekalert

Related medicine news :

1. Microbiotic technology developed for microinjection of zebrafish embryos
2. NIH awards Phylonix phase II SBIR to develop zebrafish models for eye diseases
3. Transparent zebrafish help researchers track breast cancer
4. Phylonix granted broad European patent for transplanting human cells into zebrafish
5. Zebrafish provide useful screening tool for genes, drugs that protect against hearing loss
6. Zebrafish may help solve ringing in vets ears
7. Secret to Treating Tinnitus in Vets May Be Unlocked in Zebrafish
8. Zebrafish enable scientists to study the migration of neurons that enable sexual maturity
9. Zebrafish Journal Publishes Skin Pigmentation Studies That Shed Light on the Evolution of Race
10. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
11. Health care incentive model offers collaborative approach
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... 13, 2017 , ... The Visiting Nurse Association (VNA) of Somerset Hills is ... vendors and unique items from across the nation, this holiday-themed event will raise funds ... by the VNA. The boutique will be open Saturday, November 4 (10:00 a.m. ...
(Date:10/13/2017)... ... 2017 , ... Coveros, a leader in agile coaching services ... by the Center for Medicare and Medicaid Services (CMS). The Enterprise Agile Transformation ... Agile methodologies in a consistent and high value manner across CMS programs. Coveros ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the ... today its plans to open a flagship location in Covington, LA at 401 N. ... To Go store next to Office Depot in the Holiday Square shopping center. Its ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information about the technology: ... develop to enable prevention of a major side effect of chemotherapy in children. ... pediatric patients. For cisplatin, hearing loss is FDA listed on-label as a dose ...
(Date:10/12/2017)... ... October 12, 2017 , ... Women-owned and Grand Rapids-based ... and Brightest in Wellness® by Best and Brightest. OnSite Wellness will be honored ... 20 from 7:30 a.m. to 2 p.m. at the Henry Autograph Collection Hotel, ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... , Sept. 25, 2017  EpiVax, Inc., a ... design, and immune-engineering today announced the launch of ... development of personalized therapeutic cancer vaccines. EpiVax has ... exclusive access to enabling technologies to the new ... will lead EpiVax Oncology as Chief Executive Officer. ...
(Date:9/22/2017)... -- As the latest Obamacare repeal effort moves is debated, ... and Lindsey Graham (R-SC) medical device market ... is in an odd place.  The industry wants repeal ... on medical device sales passed along with the Affordable ... visits and hospital customers with the funding to invest ...
(Date:9/19/2017)... 19, 2017 HistoSonics, Inc., a venture-backed medical device company developing a non-invasive, robotically ... announced three leadership team developments today:   ... ... Tom ... Veteran medical device executive Josh Stopek , PhD, who ...
Breaking Medicine Technology: