Navigation Links
Zebrafish offer clues to treatments for motor neurone disease
Date:4/29/2009

Tiny zebrafish could hold the key to stem cell treatments for motor neurone disease.

Scientists at the University of Edinburgh have found that these fish are able to produce motor neurones cells that control all muscle activity such as speaking, walking and breathing in humans when they repair damage to their spinal cords.

Researchers are now screening small molecules with a view to finding drugs that could kick-start the process of motor neurone regeneration in zebrafish, with a view to translating their findings into treatments for humans.

The discovery could help patients with motor neurone disease, in which the motor neurone cells die and are not replaced. This disease can cause paralysis and severe breathing difficulties and is an ultimately fatal condition for which no cure exists.

Dr Catherina Becker, from the University of Edinburgh's Centre for Neuroregeneration and Euan MacDonald Centre for Motor Neurone Disease Research, said: "Understanding how zebrafish can regenerate large numbers of motor neurones after damage to the spinal cord and how these motor neurones are produced by natural stem cells could help in finding treatments for Motor Neurone Disease.

"This could take the form of improving methods of generating motor neurones in the laboratory that could be transplanted or finding drugs which could help patients renew their motor neurone supply."

The tropical zebrafish, which are transparent and around 3 cm long, produce the motor neurones from progenitor cells found in the spinal cord that are able to turn into certain types of cells.

As well as looking at stimulating the production of motor neurones, scientists are working on ways to ensure that these cells are able to function by sending messages from the brain to the spine and then on to muscles. The research could also have implications for treating spinal cord injuries following accidents.

The research team is the first to benefit from the Edinburgh BioQuarter commercialisation initiative, funded by the University of Edinburgh and Scottish Enterprise, to assist translating research into therapies. Researchers have also received a joint grant from the Robert Packard Center in Baltimore and Euan MacDonald Centre in Edinburgh, which specialise in research into amyotrophic lateral sclerosis (ALS), the most common form of Motor Neurone Disease.


'/>"/>

Contact: Tara Womersley
tara.womersley@ed.ac.uk
01-316-509-836
University of Edinburgh
Source:Eurekalert

Related medicine news :

1. Microbiotic technology developed for microinjection of zebrafish embryos
2. NIH awards Phylonix phase II SBIR to develop zebrafish models for eye diseases
3. Transparent zebrafish help researchers track breast cancer
4. Phylonix granted broad European patent for transplanting human cells into zebrafish
5. Zebrafish provide useful screening tool for genes, drugs that protect against hearing loss
6. Zebrafish may help solve ringing in vets ears
7. Secret to Treating Tinnitus in Vets May Be Unlocked in Zebrafish
8. Zebrafish enable scientists to study the migration of neurons that enable sexual maturity
9. Zebrafish Journal Publishes Skin Pigmentation Studies That Shed Light on the Evolution of Race
10. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
11. Health care incentive model offers collaborative approach
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... , ... June 27, 2016 , ... TopConsumerReviews.com recently awarded ... Eyeglasses . , Millions of individuals in the United States and Canada wear ... a way to both correct vision and make a fashion statement. Even celebrities use ...
(Date:6/26/2016)... ... ... legally blind and certified personal trainer is helping to develop a weight loss fitness plan ... fix the two major problems leading the fitness industry today:, , ... They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... ... 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily ... of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures ... . Simply select a ProHand generator and drag it above media or text in ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits ... terms of the latter, setting the bar too high can result in disappointment, perhaps ... slow progress toward their goal. , Research from PsychTests.com reveals that ...
(Date:6/24/2016)... ... 2016 , ... The Pulmonary Hypertension Association (PHA) learned during ... two significant new grants to support its work to advance research and patient ... recognizing patients, medical professionals and scientists for their work in fighting pulmonary hypertension ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... SAN CLEMENTE, Calif. , June 24, 2016 /PRNewswire/ ... pulmonary function testing company, is now able to perform sophisticated lung ... ndd Medical Technologies , Inc. Patients are ... labs.  Thanks to ndd,s EasyOne PRO ® , ARL patients like ... any needed testing done in the comfort of her own home. ...
(Date:6/24/2016)... 24, 2016   Pulmatrix, Inc ., (NASDAQ: ... inhaled drugs, announced today that it was added to ... its comprehensive set of U.S. and global equity ... an important milestone for Pulmatrix," said Chief Executive Officer ... of our progress in developing drugs for crucial unmet ...
(Date:6/23/2016)... HOUSTON , June 23, 2016  MedSource ... platform as its e-clinical software solution of choice.  ... the best possible value to their clients by ... nowEDC.  The preferred relationship establishes nowEDC as the ... pricing for MedSource,s full-service clients.  "nowEDC has long ...
Breaking Medicine Technology: