Navigation Links
Zebrafish may help speed drug discovery
Date:1/17/2012

AUGUSTA, Ga. Tiny zebrafish just may give scientists one solution to information overload in the search for new drugs therapies.

High throughput screening, which uses robotics and computers to rapidly screen drugs, genes or proteins, to identify, for example, compounds that are best at destroying cancer or restoring insulin-producing cells. The technology has both revolutionized and stymied research, said Dr. Jeffrey Mumm, biologist in the Medical College of Georgia at Georgia Health Sciences University.

While the decade-old technology can screen 100,000 compounds in a day, there is no efficient next step for whittling to a manageable number the resulting say, 2,500 compounds that on first blush appear to have potential. Consequently, drug discovery has actually stalled, creating a scientific "indigestion," Mumm said. Drug failure rates and discovery costs, on the other hand, have escalated.

"The next best thing to do is probably take all the compounds and put them into an animal model that mimics the disease you are trying to cure but nobody has that kind of budget or would know where to start with that number of candidates," Mumm said.

One solution is pairing zebrafish with reporter-based assays that make certain parts glow, according to Mumm's research published in the journal PLoS ONE. He calls it Automated Reporter Quantification.

"It's a way to cut to the chase rather than having to make educated guess about which of the 2,500 compounds are really of interest," said Mumm. Zebrafish, which start out as single cell organisms that are fully functioning by day four, already are an invaluable research model for a wide variety of diseases, such as Mumm's efforts to regenerate cells in the face of degenerative diseases of the eyes or pancreas.

To produce a model of type 1 diabetes, for example, he uses a single drug to destroy insulin-producing cells; 24 hours later, he knows those cells are gone because the glow is gon
'/>"/>

Contact: Toni Baker
tbaker@georgiahealth.edu
706-721-4421
Georgia Health Sciences University
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. EMBL picture release: Developing zebrafish patchwork
2. Zebrafish popular with researchers
3. Researchers use zebrafish to identify new gene linked to melanoma
4. Alzheimers Foundation of America Applauds Social Security for Speeding Disability Benefits for Early-Onset Alzheimers Disease
5. Pro Athletes Brains React at Olympic Speed
6. USA's Greatest Speed Skater Takes His Medical Practice to the Cutting Edge
7. Keeping up with the neighbors speeds vaccine use
8. Bees see super color at super speed
9. After Teeth Are Pulled, Platelet-Rich Plasma May Speed Healing
10. Nausea and speeding heart can be signs of flu in pregnant women
11. Getting Help with Initial Social Security Disability Application Can Speed Access to Benefits
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Zebrafish may help speed drug discovery
(Date:8/29/2015)... ... August 30, 2015 , ... Rio Salado College ... serve as the college’s Vice President of Strategic Initiatives and Information Services. O’Shea, who ... help the college expand its reach and impact through innovative technologies and strategies. , ...
(Date:8/29/2015)... (PRWEB) , ... August 29, 2015 , ... ... one of two inventors from Miller Place, N.Y. "I specialize in manual therapy, ... discomfort. In addition, it can be used for additional muscle dysfunction throughout the ...
(Date:8/29/2015)... ... August 29, 2015 , ... Brands like Toppik , Eau Thermale ... costs. , “Before, a threshold of $49.00 was required to qualify for free standard ... for free standard shipping for customers regardless of the item’s selling price.” , With ...
(Date:8/29/2015)... ... August 29, 2015 , ... ... treating the localized area with stretching, soft tissue manipulation. Platelet rich plasma injections ... have shown through research to improve treatment outcomes. This localized treatment seems ...
(Date:8/28/2015)... ... August 28, 2015 , ... Joining a growing number ... recently transitioned management companies to partner with Wound Care Advantage (WCA) to utilize ... center. , Transitioning wound care management providers can be a complex undertaking. ...
Breaking Medicine News(10 mins):Health News:Rio Salado College Appoints New Vice President of Strategic Initiatives and Information Services 2Health News:Inventors and InventHelp Clients Develops Tension Reliever (LGI-1951) 2Health News:TheBeautyPlace.com Discounts Shipping on Select Brands 2Health News:NEW APPROACH for Treatment of Recurrent Hamstring Strains and Hamstring Tendinosis is Available for the First Time in NYC 2Health News:NEW APPROACH for Treatment of Recurrent Hamstring Strains and Hamstring Tendinosis is Available for the First Time in NYC 3Health News:Decatur County Memorial Hospital Transitions Wound Center Management To Wound Care Advantage and the Luvo Operating System 2Health News:Decatur County Memorial Hospital Transitions Wound Center Management To Wound Care Advantage and the Luvo Operating System 3Health News:Decatur County Memorial Hospital Transitions Wound Center Management To Wound Care Advantage and the Luvo Operating System 4
... Texas Mutual Insurance Company, an,aggressive tort reform advocate ... pending litigation in which the insurance company tried,to overturn ... for a workplace injury,a Dallas state district judge ruled ... falsified medical record,Texas Mutual had no evidence to continue ...
... CHICAGO, Jan. 9 To make your New ... Pretzels(R) (K&SGP) introduces its,Empowered Pretzel(TM), the first of ... healthful twist on the traditional pretzel. The,pretzel is ... http://www.kimandscotts.com or by calling the company at ...
... Health Care,Associates, Inc. (MHA), the nation,s largest alternate ... members, Mr. Barry R. Freedman and,Mr. Brian Wheelan ... and Mr.,Wheelan join seven existing board members representing ... Barry Freedman is President and Chief Executive Officer ...
... GSI Group Inc.,(Nasdaq: GSIG ), a leading ... it will be presenting at both the,Needham & Company ... January,10th and the Fifth Annual Sidoti & Company Emerging ... Mr. Robert Bowen, Chief Financial Officer, will be speaking ...
... Jan. 9 /PRNewswire-FirstCall/ - AlphaRx (OTC BB:ALRX -,News) stated ... of,AlphaRx Inc Common Stock in the open market, bringing ... last 60 days, reflecting his,continued confidence in the Company,s ... of 720,000 AlphaRx shares for,an average price of $0.24 ...
... 2008 Meeting of the American Psychoanalytic Association, psychoanalysts Susan ... Ph.D. (Boston, MA) will lead a discussion regarding "Psychoanalytic ... Dialogue between Psychoanalysis and Neurobiology." This session will be ... 10: 00 pm at the Waldorf-Astoria Hotel, 301 Park ...
Cached Medicine News:Health News:Judge Rules Texas Mutual Insurance Co. Committed Litigation Fraud With Falsified Document, According to Doyle Raizner LLP 2Health News:Kim & Scott's Gourmet Pretzels(R) Introduces Its First Empowered Pretzel(TM) Available Online and to Wholesale 2Health News:MHA Announces: Managed Health Care Associates, Inc. (MHA) Expands Board of Directors 2Health News:MHA Announces: Managed Health Care Associates, Inc. (MHA) Expands Board of Directors 3Health News:GSI to Present at Upcoming Investor Growth Conferences 2
(Date:8/28/2015)... CHAPEL HILL, N.C. , Aug. 28, 2015 ... critical market research projects can slow down the ... costs. It is, therefore, absolutely critical for biopharmaceutical ... the market research approval process for quicker and ... recent research by Best Practices, LLC, nearly three-quarters ...
(Date:8/28/2015)... 2015 Research and ... of the "Investigation Report on China,s Pranoprofen ... Originally discovered by Welfide (Mitsubishi Tanabe Pharma ... as an inflammatory drug, pranoprofen was later developed ... under the trade name of pranopulin for the ...
(Date:8/28/2015)... 2015 Research and Markets ... "Investigation Report on China,s Tobramycin Market, 2010-2019" ... traditional antibiotic whose eye drop and ointment are the ... infection or inflammation caused by eye infection. Currently, dozens ... able to produce tobramycin, among which the Top 5 ...
Breaking Medicine Technology:Expediting the Pharmaceutical Market Research Process for Faster Insights 2Investigation Report on China's Pranoprofen Market, 2010-2019 2Investigation Report on China's Tobramycin Market, 2015-2019 2
... 2010 Genomic Health, Inc. (Nasdaq: GHDX ) today ... 30, 2010. Total revenue increased to $46.3 million in ... third quarter of 2009.  Product revenue was $45.8 million in the ... $38.9 million in the third quarter of 2009. ...
... Nov. 8, 2010 PRNewswire-FirstCall/ -- Mesa Laboratories, Inc. (Nasdaq: ... has declared a regular quarterly dividend of $.12 per share ...  The dividend will be payable December 15, 2010, to shareholders ... public in 1984 Mesa Labs has maintained strong cash positions ...
Cached Medicine Technology:Genomic Health Announces Third Quarter 2010 Financial Results and Business Progress 2Genomic Health Announces Third Quarter 2010 Financial Results and Business Progress 3Genomic Health Announces Third Quarter 2010 Financial Results and Business Progress 4Genomic Health Announces Third Quarter 2010 Financial Results and Business Progress 5Genomic Health Announces Third Quarter 2010 Financial Results and Business Progress 6Genomic Health Announces Third Quarter 2010 Financial Results and Business Progress 7Genomic Health Announces Third Quarter 2010 Financial Results and Business Progress 8
... revised charts incorporate the slight change in ... 10 Sloan letters derived from the best ... during the ETDRS study. The original charts ... of 234 eyes. In addition to the ...
... The Stereo Tower is used to ... and adults without the use of ... tests can be used for study, testing ... form and depth perception. The instruction card ...
... to simplify stereopsis screening in children. It is ... gratings. Lang Stereotest II measures disparities: Moon and ... seconds of arc plus monocularly visible star. In ... are smaller and less dense. This disparity is ...
... This "natural" Stereotest consists of three test plates(6mm, ... measurements in a range of 600 - 15 ... shape can only be detected if stereopsis is ... the risk of the patient learning the correct ...
Medicine Products: