Navigation Links
Zebrafish enable scientists to study the migration of neurons that enable sexual maturity
Date:6/5/2008

testes to produce testosterone and sperm. But first, GnRH neurons must get to the brain. "This occurs very early in the life of a zebrafish, probably after the heart forms, at about 48 to 72 hours of life," says Dr. Kozlowski. "One class of patients Dr. Layman sees has Kallmann syndrome in which there is evidence that the GnRH neurons gets stuck about halfway. People want to know the molecular mechanism that allows these neurons to find the right place." Dr. Kozlowski is principal investigator on a new $1.4 million grant from the National Institutes of Health that should help.

The zebrafish embryo, which is transparent and develops outside the mother, is ideal for studying early development. Dr. Kozlowski's lab, in collaboration with UCLA's Dr. Wayne, made a transgenic fish whose GnRH neurons turn fluorescent green at birth for easy tracking. "We can put them under the microscope and image them for as long as it takes for these cells to get from point A to point B and ask how they got there," says Dr. Kozlowski. "Do they go straight there or take the long way? Then we can start asking questions about the signals that direct them and dissect out the genes expressed along the route which may function as road signs."

In live embryos, researchers are watching GnRH neurons as they first appear near the developing nose, then migrate with nearby olfactory neurons. "People actually think they use these olfactory neurons as the highway, which makes sense," says Dr. Kozlowski. "They are already there and moving to the brain. Why not follow the yellow brick road?" In fact, some patients with Kallmann syndrome, who have delayed puberty, also have impaired or no ability to smell, indications both neuron types may get off route.

Dr. Wayne uses tiny recording pipettes to measure the GnRH neuron's electrical activity as they travel. In cell culture systems at least, there is a known relationship between electrical activity in these neurons and thei
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Secret to Treating Tinnitus in Vets May Be Unlocked in Zebrafish
2. Zebrafish may help solve ringing in vets ears
3. Zebrafish provide useful screening tool for genes, drugs that protect against hearing loss
4. Phylonix granted broad European patent for transplanting human cells into zebrafish
5. Transparent zebrafish help researchers track breast cancer
6. NIH awards Phylonix phase II SBIR to develop zebrafish models for eye diseases
7. Microbiotic technology developed for microinjection of zebrafish embryos
8. Techno-Savvy Public Awareness Campaign Enables Families to Send a Powerful Message About Childrens Mental Health
9. Anthem Blue Cross and Blue Shield in Connecticut Introduces Industrys First Electronic Tool to Help Members Search In-Network Doctors and Hospitals; Transparency Tool to Enable Searches Via Web-Enabled Cell Phones or Hand-Held Devices
10. Preoperative assessment of cancer patients enables early diagnosis, treatment of lymphedema
11. Intronis Technologies to Launch Partner Enablement Program at INTEROP 2008
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Zebrafish enable scientists to study the migration of neurons that enable sexual maturity
(Date:7/31/2015)... West Orange, NJ (PRWEB) , ... July 31, ... ... of obstructive sleep apnea (OSA) and the growing number of individuals who remain ... millions of Americans continue to shy away from traditional CPAP therapy due to ...
(Date:7/30/2015)... ... , ... Dale Sky Jones, Executive Chancellor of Oaksterdam University , the ... Expo held at the Caribe Royal All Suites Hotel and Convention Center in Orlando, ... the largest medical cannabis expo in the country and this year’s expo will be ...
(Date:7/30/2015)... Islands, BWI (PRWEB) , ... July 31, 2015 , ... The Venetian on Grace Bay ... 2015. Guests who stay at the Venetian will save 40% on their stay while ... months are always quiet in the Turks & Caicos, providing a chance to reconnect with ...
(Date:7/30/2015)... York (PRWEB) , ... July 31, 2015 , ... Committed ... call to action by asking community members to contribute to the College’s “My Brother’s ... more of our young people stay on track. Providing the support they need to ...
(Date:7/30/2015)... ... July 30, 2015 , ... As more hospitals across the country see ... becomes a serious challenge. Because of growing competition, it is more important than ... community. , The team at Wound Care Advantage has found that ...
Breaking Medicine News(10 mins):Health News:Oravan Sleep Apnea Device Gains Traction in Sleep Industry 2Health News:Finally…First Ever Professional Training Event for Doctors and Nurses Wanting to Offer Medical Marijuana Recommendations to Patients 2Health News:Finally…First Ever Professional Training Event for Doctors and Nurses Wanting to Offer Medical Marijuana Recommendations to Patients 3Health News:Finally…First Ever Professional Training Event for Doctors and Nurses Wanting to Offer Medical Marijuana Recommendations to Patients 4Health News:Finally…First Ever Professional Training Event for Doctors and Nurses Wanting to Offer Medical Marijuana Recommendations to Patients 5Health News:The Venetian on Grace Bay in Turks & Caicos Islands Offers 40% Savings This Fall. 2Health News:Mercy College a “My Brother’s Keeper” Community 2Health News:Mercy College a “My Brother’s Keeper” Community 3Health News:WCA Offers Shockwave; The Marketing Module for Hospital Wound Care Programs 2Health News:WCA Offers Shockwave; The Marketing Module for Hospital Wound Care Programs 3Health News:WCA Offers Shockwave; The Marketing Module for Hospital Wound Care Programs 4
... Fair Trade-Certified Drink Featured in ... of Top Great-For-You Products, NEWTOWN, Pa., Sept. 3 ... beverages, has been included on,Women,s Health list of the 125 ... was featured on the list in the Drinks,category. In recognizing ...
... of aggressive disease , , WEDNESDAY, Sept. 3 (HealthDay News) ... high end of the normal range are three times ... report shows. , The results suggest the possibility of ... said. But one expert cautioned against reading too much ...
... July, Christine Demers and Areeba Sadiq set off for a family reunion ... for Medical Research were not blood relatives but they were going West ... DNA. , ... (PRWEB) September 3, 2008 -- In July, Christine Demers ...
... The CtW Investment Group sent the,following letter today to ... Mary S. Metz in response to the news,that Longs ... to reveal the value of its real estate portfolio., ... 2, 2008, Dr. Mary S. Metz, Chairperson, ...
... MUNDELEIN, Ill., Sept. 3 Z Trim Holdings,Inc. (Amex: ... September 3, 2008, To: Z ... Dear Fellow Shareholders, In this second installment of periodic ... shed more light on the motives and,outcomes -- realized and ...
... Imagine having to copy an entire book by hand without ... time they divide. They must duplicate both their DNA and ... as methylation. , Scientists at Emory University School of Medicine ... use to maintain their pattern of methylation. Visualized by X-ray ...
Cached Medicine News:Health News:Steaz Named to Women's Health List of 125 Best Packaged Foods for Women 2Health News:Study Links Serum Calcium, Prostate Cancer Death 2Health News:Study Links Serum Calcium, Prostate Cancer Death 3Health News:Feinstein Institute: Researching a Family Tree of Autoimmune Disorders 2Health News:Feinstein Institute: Researching a Family Tree of Autoimmune Disorders 3Health News:Feinstein Institute: Researching a Family Tree of Autoimmune Disorders 4Health News:Feinstein Institute: Researching a Family Tree of Autoimmune Disorders 5Health News:CtW Investment Group Believes Longs RE Undervalued - Calls for Greater Disclosure 2Health News:CtW Investment Group Believes Longs RE Undervalued - Calls for Greater Disclosure 3Health News:CtW Investment Group Believes Longs RE Undervalued - Calls for Greater Disclosure 4Health News:CtW Investment Group Believes Longs RE Undervalued - Calls for Greater Disclosure 5Health News:CtW Investment Group Believes Longs RE Undervalued - Calls for Greater Disclosure 6Health News:CtW Investment Group Believes Longs RE Undervalued - Calls for Greater Disclosure 7Health News:Z Trim Holdings, Inc. Releases Letter to Shareholders 2Health News:Z Trim Holdings, Inc. Releases Letter to Shareholders 3Health News:Z Trim Holdings, Inc. Releases Letter to Shareholders 4Health News:Z Trim Holdings, Inc. Releases Letter to Shareholders 5Health News:Z Trim Holdings, Inc. Releases Letter to Shareholders 6Health News:DNA editing tool flips its target 2
(Date:7/30/2015)...  Amgen (NASDAQ: AMGN ) today announced the appointment ... Warburg Pincus LLC, to the Amgen Board of Directors. ... and the deep, global experience he brings in the ... Bradway , chairman and chief executive officer of Amgen. "Fred,s breadth ... well." Mr. Hassan has been Partner and Managing ...
(Date:7/30/2015)... Ohio , July 30, 2015  Cleveland Clinic ... OMTEC® 2015 keynote address last month that industry is ... in order to gain the efficiencies—and develop the transformational ... Dr. Barsoum,s comments were preceded by Doug ... entrepreneur and OMTEC moderator, who stressed that industry must ...
(Date:7/30/2015)...  Growth of the U.S. nonprescription market is primarily ... users to the OTC market. Due to an increasingly ... switch activity over the next five years with several ... brands entering the market into existing categories. ... (even those with low to moderate likelihood), the market ...
Breaking Medicine Technology:Amgen Announces Appointment Of Fred Hassan To Board Of Directors 2Amgen Announces Appointment Of Fred Hassan To Board Of Directors 3Orthopaedic Surgery Reimbursement Shifts to Episode of Care 2Rx-to-OTC Switches -- Game Changers for the U.S. OTC Drugs Market through 2019, Sees Kline 2Rx-to-OTC Switches -- Game Changers for the U.S. OTC Drugs Market through 2019, Sees Kline 3
... , SAN DIEGO, Sept. 11 Calixa ... development and commercialization of novel antibiotics for the treatment ... in 20 posters at the Interscience Conference on Antimicrobial ... San Francisco on September 12 to 15, 2009. ...
... , , , ... preliminary schedule of events at the Cardiovascular Research Foundation,s (CRF) ... September 21st to Friday, September 25th, in San Francisco, CA. ... the world,s largest events for those performing cardiac diagnostics and ...
Cached Medicine Technology:Calixa Therapeutics to Make Multiple Presentations on CXA-101 and CXA-101/tazobactam at the 49th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy 2Calixa Therapeutics to Make Multiple Presentations on CXA-101 and CXA-101/tazobactam at the 49th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy 3Calixa Therapeutics to Make Multiple Presentations on CXA-101 and CXA-101/tazobactam at the 49th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy 4InfraReDx to Showcase the LipiScan(TM) Coronary Imaging System at the Cardiovascular Research Foundation's (CRF) Annual Transcatheter Cardiovascular Therapeutics (TCT) Scientific Meeting 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: