Navigation Links
Zebrafish enable scientists to study the migration of neurons that enable sexual maturity
Date:6/5/2008

testes to produce testosterone and sperm. But first, GnRH neurons must get to the brain. "This occurs very early in the life of a zebrafish, probably after the heart forms, at about 48 to 72 hours of life," says Dr. Kozlowski. "One class of patients Dr. Layman sees has Kallmann syndrome in which there is evidence that the GnRH neurons gets stuck about halfway. People want to know the molecular mechanism that allows these neurons to find the right place." Dr. Kozlowski is principal investigator on a new $1.4 million grant from the National Institutes of Health that should help.

The zebrafish embryo, which is transparent and develops outside the mother, is ideal for studying early development. Dr. Kozlowski's lab, in collaboration with UCLA's Dr. Wayne, made a transgenic fish whose GnRH neurons turn fluorescent green at birth for easy tracking. "We can put them under the microscope and image them for as long as it takes for these cells to get from point A to point B and ask how they got there," says Dr. Kozlowski. "Do they go straight there or take the long way? Then we can start asking questions about the signals that direct them and dissect out the genes expressed along the route which may function as road signs."

In live embryos, researchers are watching GnRH neurons as they first appear near the developing nose, then migrate with nearby olfactory neurons. "People actually think they use these olfactory neurons as the highway, which makes sense," says Dr. Kozlowski. "They are already there and moving to the brain. Why not follow the yellow brick road?" In fact, some patients with Kallmann syndrome, who have delayed puberty, also have impaired or no ability to smell, indications both neuron types may get off route.

Dr. Wayne uses tiny recording pipettes to measure the GnRH neuron's electrical activity as they travel. In cell culture systems at least, there is a known relationship between electrical activity in these neurons and thei
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Secret to Treating Tinnitus in Vets May Be Unlocked in Zebrafish
2. Zebrafish may help solve ringing in vets ears
3. Zebrafish provide useful screening tool for genes, drugs that protect against hearing loss
4. Phylonix granted broad European patent for transplanting human cells into zebrafish
5. Transparent zebrafish help researchers track breast cancer
6. NIH awards Phylonix phase II SBIR to develop zebrafish models for eye diseases
7. Microbiotic technology developed for microinjection of zebrafish embryos
8. Techno-Savvy Public Awareness Campaign Enables Families to Send a Powerful Message About Childrens Mental Health
9. Anthem Blue Cross and Blue Shield in Connecticut Introduces Industrys First Electronic Tool to Help Members Search In-Network Doctors and Hospitals; Transparency Tool to Enable Searches Via Web-Enabled Cell Phones or Hand-Held Devices
10. Preoperative assessment of cancer patients enables early diagnosis, treatment of lymphedema
11. Intronis Technologies to Launch Partner Enablement Program at INTEROP 2008
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Zebrafish enable scientists to study the migration of neurons that enable sexual maturity
(Date:12/20/2014)... 20, 2014 Today, Balfleet.com, one of ... Christmas Sale, offering 50%-70% off on its Mother ... , The mother of the bride dresses from Balfleet.com ... is 24/7 accessible and takes pride in providing high ... “We are offering great discounts on our mother of ...
(Date:12/19/2014)... It’s very easy to become overwhelmed with the holidays ... the wayside until Christmas and the New Year are over. ... that burning desire to just escape it all and get ... Telluride with a no-fuss, affordable package. Montrose Days Inn will ... and ensure that all accommodations are met. Plus, everyone has ...
(Date:12/19/2014)... Florida (PRWEB) December 19, 2014 Sub Zero ... to sponsor a blood drive Sunday the 28th from 2pm-6pm ... Road & Sawyer Road in Sarasota, FL. , Inquiries regarding ... thank you for participating in the donating process, Sub Zero ... free flash frozen, custom ice cream. , About Sub Zero ...
(Date:12/19/2014)... (PRWEB) December 19, 2014 ... dedicated to developing educational events, tools and resources ... Rouxbe Cooking School , the world’s leading online ... prescription every human being needs: Culinary Rx. As ... cooking course, Culinary Rx, scheduled for debut spring ...
(Date:12/19/2014)... Santa Rosa, CA (PRWEB) December 19, 2014 ... 2x4 and 5x5 SuperClone Rooms. SuperCloset continues to offer ... grow solutions. Pair one of the new SuperClone Rooms ... truly professional, perpetual, and turnkey indoor hydroponic grow room ... cloner in the world, SuperCloset’s SuperPonic SuperCloner 50 ...
Breaking Medicine News(10 mins):Health News:Balfleet.com is Offering 50%-70% Off of its Mother of the Bride Dresses 2Health News:Days Inn Montrose Colorado Delivers Last Minute Holiday Season Ski Getaway Accommodations 2Health News:Shark Tank’s Sub Zero Ice Cream Sponsors Blood Drive 2Health News:The Plantrician Project and the Rouxbe Cooking School Join Forces to Develop Culinary Rx – a Plant-Prescription Course 2Health News:The Plantrician Project and the Rouxbe Cooking School Join Forces to Develop Culinary Rx – a Plant-Prescription Course 3Health News:The Plantrician Project and the Rouxbe Cooking School Join Forces to Develop Culinary Rx – a Plant-Prescription Course 4Health News:SuperCloset Continues to Innovate with New Complete Indoor Grow Room Packages, The SuperClone Rooms are the Newest Addition to the Award Winning SuperRoom Lineup 2
... Massachusetts General Hospital (MGH), together with a coalition of ... world,s largest registry of patients who have had optical ... an intravascular imaging technology that researchers hope will give ... plaques that cause heart attacks and sudden cardiac death. ...
... finds , THURSDAY, March 25 (HealthDay News) -- More than ... said that they drank alcohol in the past month, according ... The analysis of 2006-2008 data from the National Survey on ... rates were as high as 40 percent in some states, ...
... The effectiveness of ordinary surgical masks as opposed to ... H1N1 influenza virus has been the subject of debate. ... issue of Clinical Infectious Diseases, available online ... as effective as respirators in this regard. ...
... ... strategy to treat motor symptoms in rats with a disease designed to mimic Parkinson,s disease. ... San Francisco, CA (Vocus) ... symptoms in rats with a disease designed to mimic Parkinson,s disease., , , , ,The ...
... This press release is available in French . ... a previously hidden channel to attack leukemia and other cancer ... Journal of Biological Chemistry . The findings from the Universit ... way doctors treat cancer patients. "We found a gateway, ...
... survey finds , THURSDAY, March 25 (HealthDay News) ... likely to be chronically offline: they use the Internet ... , The survey, conducted by the Pew Internet & ... published online March 24, found that just 62 percent ...
Cached Medicine News:Health News:Mass. General Hospital to create registry for coronary optical coherence tomography 2Health News:Underage Drinking Soars in U.S. 2Health News:Novel Parkinson's Treatment Strategy Involves Cell Transplantation 2Health News:Novel Parkinson's Treatment Strategy Involves Cell Transplantation 3Health News:Novel Parkinson's Treatment Strategy Involves Cell Transplantation 4Health News:New gateway to treat leukemia and other cancers 2Health News:Chronic Disease Linked to Less Internet Usage 2
(Date:12/19/2014)... 19, 2014  Newport Corporation (NASDAQ: ... has joined the company,s Board of Directors.  Dr. ... a director of Evans Analytical Group, a leading ... analytical services to companies in a wide range ... Evans Analytical Group, Dr. Kadia spent nine years ...
(Date:12/19/2014)... 2014 Breckenridge Pharmaceutical, Inc. announced today that ... Laboratories Pvt. Ltd. ( Hyderabad, India ) ... new ANDAs.  Under the terms of the agreement, MSN ... Breckenridge for the U.S. market, and Breckenridge will market ... MSN have agreed to develop an oral antibiotic with ...
(Date:12/19/2014)... , Dec. 19, 2014 In ... research and marketing communication tools are essential for ... competitive – consequently consumers, desires, preferences, and unmet ... environment, market research groups across all industries are ... communication tools. However, the adoption of new market ...
Breaking Medicine Technology:Siddhartha Kadia, Ph.D. Joins Board of Directors of Newport Corporation 2Breckenridge Pharmaceutical signs Multi-Product Generic Agreement with MSN Laboratories Pvt. Ltd. 2Study Uncovers New Tools and Techniques for Understanding Consumer Decision Making 2
... SKILLMAN, N.J., Feb. 7, 2011 ConvaTec, a world-leading ... and hospital care, today announced the appointment of several ... Nino Pionati has been appointed President, Intercontinental in ... Latin America and Canada. These markets continue to be ...
... 2011 BioSpecifics Technologies Corp. (Nasdaq: BSTC ... first in class collagenase-based products, today announced that its ... "Rights Agreement"), adopted May 14, 2002 and previously amended ... increases the ownership threshold for determining "Acquiring Person" status ...
Cached Medicine Technology:ConvaTec Announces New Appointments to Leadership Team 2
... The Evans AFO is designed to ... disorders associated with immobility such as hip ... at the calcaneus. A comfortable Kodel lining ... patient. The anti-rotation bar is easily ...
Provides secure fracture immobilization while allowing for full range of motion at shoulder and elbow...
... MPO® by RCAI provides adjustable static stretch ... conditions such as diminished foot and ankle ... rotation. Medial/lateral straps attached to the sides ... ankle to be controlled, as needed, in ...
... features a completely padded posterior shell ... to provide passive flexion to help ... or Achilles tendonitis. Its neutral ... left or right. A foam ...
Medicine Products: