Navigation Links
ZOLINZA (vorinostat) in combination with bortezomib demonstrated clinical activity
Date:12/8/2007

okinetic and pharmacodynamic activity of the combination regimen. Patients also were evaluated for response and tolerability.

The median age of patients in the study was 54 years (39-78) and the median number of prior therapies was 7 (range of 3-13), with 19 patients previously treated with bortezomib.

Results of the study showed that the MTD for the combination regimen was achieved at ZOLINZA 400 mg daily for 8 days plus bortezomib 1.3 mg/ m2 days 1, 4, 8 and 11 respectively. Forty-three percent of patients had a partial response or greater (1 VGPR and 9 PR) following treatment with the ZOLINZA and bortezomib combination regimen, assessed using the International uniform response criteria for multiple myeloma. Among the 19 patients previously treated with bortezomib, one achieved a very good partial response and six had a partial response. Two patients experienced dose-limiting toxicities (fatigue and prolonged QT interval). Some of the non-hematological toxicities grade 2 and higher included fatigue (n=9), nausea (n=6), vomiting (n=3), diarrhea (n=3), pneumonia (n=3, bacterial and RSV), shingles (n=2) and atrial fibrillation (n=1).

Based on these initial results presented for the first time, Merck is evaluating plans to accelerate testing of ZOLINZA in combination with bortezomib in the randomized clinical trial setting to further define the clinical activity in relapsed or refractory multiple myeloma," said Dr. Garcia-Vargas.


'/>"/>

Contact: Gina Juliano
gina_juliano@cohnwolfe.com
917-359-5521
Cohn & Wolfe
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Promising drug combination may help those with ocular melanoma that has spread
2. Combination therapy reverses effects of portal hypertension in rats
3. Combination vaccines okay for infants, study shows
4. Antidepressants and painkillers - a dangerous combination
5. Intra-arterial combination chemotherapy induces long-term survival for hepatocellular carcinoma
6. U.S. Oncology Initiates Complete Phase Ib Trial of Brostallicin Combination Therapy in Advanced Solid Tumors
7. Drug combination might offer hope for patients deadly brain tumors
8. EpiCept to Present Preclinical Studies of EPC2407 in Combination With Anti-Angiogenic and Chemotherpeutic Agents at the AACR-NCI-EORTC International Conference
9. Combination targets: some drugs may work best when they work together
10. MAP Pharmaceuticals Initiates Phase 2a Clinical Trial of Combination Therapy in Adult Patients with Asthma
11. Quality Control: Nissan Quest to Feature micronAir(R) Combination Cabin Air Filters
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/18/2014)... AZ (PRWEB) November 18, 2014 ... in medical information, risk management and investigative services, ... Star Examiner Performance Model to enhance its paramedical ... distribution partners. Through use of EMSI’s 5 ... in knowing that their paramedical exams are conducted ...
(Date:11/18/2014)... By Dennis Thompson ... (HealthDay News) -- Driving "bad" LDL cholesterol down to ... significantly reduce heart attacks and strokes in high-risk patients ... experienced fewer heart attacks and strokes when taking Vytorin, ... with a non-statin medication called ezetimibe, said principal investigator ...
(Date:11/18/2014)... 2014 (HealthDay News) -- Routine screening for heart disease ... symptoms but are at high risk for a heart ... the screenings do not help prevent heart attacks or ... unstable angina (chest pain that occurs when the heart ... is still the best way to manage risks for ...
(Date:11/18/2014)... BellasDress has announced the launch of 85 new models of ... fabrics, the new styles of prom dresses have attracted many ... gifts in a variety of colors and styles. , “We ... are created by top designers,” said the vice president for ... our sales team and more than one client has told ...
(Date:11/18/2014)... 18, 2014 OpenWorks, one of America’s ... the 2014 Lincoln Guild Invitational. The John C. Lincoln ... support the Phoenix-area Desert Mission community programs. Open Works ... The tournament was held at Camelback Golf Club in ... the efforts of Desert Mission — including a food ...
Breaking Medicine News(10 mins):Health News:EMSI Launches Proprietary 5 Star Examiner Performance Model to Enhance Paramedical Exam Service 2Health News:Cholesterol Drug Vytorin Linked to Reduced Heart Attack Risk 2Health News:Cholesterol Drug Vytorin Linked to Reduced Heart Attack Risk 3Health News:Study Finds No Added Benefit From Routine Heart Scans for Diabetics 2Health News:Study Finds No Added Benefit From Routine Heart Scans for Diabetics 3Health News:85 New Models Of White Prom Dresses From BellasDress.com Online For Sale 2Health News:OpenWorks Sponsors 2014 Lincoln Guild Invitational Golf Tournament Hosted by Scottsdale's Camelback Golf Club 2
... 2012, SAN FRANCISCO A further analysis of a ... (NHLBI) funded study of children with mild persistent asthma ... varies among children with differing demographic and clinical characteristics. ... children enrolled in the TReating Children to Prevent Exacerbations ...
... flu shot during pregnancy provides unanticipated benefits to the ... study examining the issue. Specifically, the study showed that ... significantly reduced risk of stillbirth, preterm birth and extremely ... Hospital Research Institute (OHRI), the CHEO Research Institute and ...
... Gardner HealthDay Reporter , MONDAY, May 21 (HealthDay ... Fantastic Voyage , researchers have found a way to perform ... local anesthetic. The procedure, done with moveable magnets, is ... reroutes the digestive tract without leaving behind any foreign material. ...
... Reporter , MONDAY, May 21 (HealthDay News) -- The food ... Crohn,s disease by encouraging the growth of E. coli bacteria ... researchers stressed that the findings are preliminary and the tests ... too soon to advise those with the inflammatory bowel disease ...
... a scientist from the Viral Immunology Center at Georgia ... infection of the eye is associated with neovascular age-related ... the elderly. The scientists found that human cytomegalovirus, ... endothelial growth factor, or VEGF, a signal protein that ...
... that University of Cincinnati design students Alex Broerman and Ashley ... prototype for a prescription-medicine pill bottle that better serves the ... a simple and inexpensive innovation. In fact, the two ... a design intended to have universal appeal but to ...
Cached Medicine News:Health News:Baseline characteristics of children with mild persistent asthma predict response to ICS 2Health News:Flu shot during pregnancy shows unexpected benefits in large study 2Health News:Moveable Magnets Used to Forge Gastric Bypass in Pigs 2Health News:Moveable Magnets Used to Forge Gastric Bypass in Pigs 3Health News:Could Compound in Artificial Sweeteners Worsen Crohn's Disease? 2Health News:Could Compound in Artificial Sweeteners Worsen Crohn's Disease? 3Health News:Type of viral infection of eye associated with disease causing blindness in the elderly 2Health News:UC students design a better pill bottle for the blind and visually impaired 2Health News:UC students design a better pill bottle for the blind and visually impaired 3
(Date:11/18/2014)... 2014 SynCardia Systems, Inc., has been recognized ... Small Companies presented by the Arizona Technology Council in ... 11th annual Governor,s Celebration of Innovation Awards honor technology ... Arizona Governor Jan Brewer ... was honored for its Freedom® portable driver, which powers ...
(Date:11/18/2014)... , Nov. 17, 2014  Nopras Technologies ... Stewart B. Rosenberg to the position ... Mr. Rosenberg joins Nopras from Bio-Investigations Ltd., a ... consultancy he founded 27 years ago, focused in ... care.  With undergraduate and graduate degrees in biology, ...
(Date:11/18/2014)... -- Zimmer Holdings, Inc. (NYSE and SIX: ZMH) ("Zimmer") announced ... (the "EC") to extend the deadline for the EC,s ... limited number of days in order to provide the ... extensions are not uncommon in such in-depth investigations.  Zimmer ... facilitate their review of the pending transaction and is ...
Breaking Medicine Technology:SynCardia Named Innovator of the Year by the 2014 Governor's Celebration of Innovation Awards for Its Freedom Portable Driver 2SynCardia Named Innovator of the Year by the 2014 Governor's Celebration of Innovation Awards for Its Freedom Portable Driver 3Nopras Technologies Inc. Appoints Director Of Business Development - East Coast Operations 2Nopras Technologies Inc. Appoints Director Of Business Development - East Coast Operations 3Zimmer Provides Update on the European Commission Review Process Relating to the Pending Merger with Biomet, Inc. 2Zimmer Provides Update on the European Commission Review Process Relating to the Pending Merger with Biomet, Inc. 3Zimmer Provides Update on the European Commission Review Process Relating to the Pending Merger with Biomet, Inc. 4Zimmer Provides Update on the European Commission Review Process Relating to the Pending Merger with Biomet, Inc. 5
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: