Navigation Links
ZOLINZA (vorinostat) in combination with bortezomib demonstrated clinical activity
Date:12/8/2007

or 400 mg daily for 14 days in combination with bortezomib 0.7 or 0.9 mg/m2 I.V. on days 4, 8, 11 and 15 or in combination with bortezomib 0.9, 1.1, or 1.3 mg/m2 I.V. on days 1, 4, 8 and 11. Cycles were repeated every 21 days for a maximum of 8 cycles until progressive disease or intolerable toxicity. The primary objective was to determine MTD; secondary objectives included assessment of activity (using EBMT criteria) and safety and tolerability of the combination regimen. The median age of patients in the study was 61 years (45-76) and the median number of prior anti-cancer therapies was 3 (range of 1-14), with 25 percent (n=6) of patients previously treated with bortezomib.

Although the MTD has not yet been determined, of the 21 evaluable patients who received the combination regimen, as assessed using EBMT criteria, 48 percent had a partial (n=5) or minimal (n=5) response. Among the six patients previously treated with bortezomib, two achieved a partial response and three had a minimal response. Two patients experienced dose-limiting toxicities (transient AST elevation and thrombocytopenia). The most common drug-related adverse events among all patients were nausea (n=14), thrombocytopenia (n=13), diarrhea (n=12), vomiting (n=12), fatigue (n=10) anemia (n=6) and neutropenia (n=6). Accrual continues to determine the MTD.

In the second Phase I study lead by Dr. Ashraf Badros, University of Maryland, and sponsored by the Division of Cancer Treatment and Diagnosis, National Cancer Institute, 23 patients with relapsed or refractory multiple myeloma were administered oral ZOLINZA (100 mg bid, 200 mg bid, 400 mg daily or 500 mg daily) on days 4-11 over a 21-day period in combination with bortezomib (1.0 or 1.3 mg/m2 I.V. on days 1, 4, 8 and 11). Cycles were repeated every 21 days for a maximum of 8 cycles. If no response was observed at Cycle 2, dexamethasone 20 mg was added on days 4-8. The primary objective was to determine the MTD and pharmac
'/>"/>

Contact: Gina Juliano
gina_juliano@cohnwolfe.com
917-359-5521
Cohn & Wolfe
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Promising drug combination may help those with ocular melanoma that has spread
2. Combination therapy reverses effects of portal hypertension in rats
3. Combination vaccines okay for infants, study shows
4. Antidepressants and painkillers - a dangerous combination
5. Intra-arterial combination chemotherapy induces long-term survival for hepatocellular carcinoma
6. U.S. Oncology Initiates Complete Phase Ib Trial of Brostallicin Combination Therapy in Advanced Solid Tumors
7. Drug combination might offer hope for patients deadly brain tumors
8. EpiCept to Present Preclinical Studies of EPC2407 in Combination With Anti-Angiogenic and Chemotherpeutic Agents at the AACR-NCI-EORTC International Conference
9. Combination targets: some drugs may work best when they work together
10. MAP Pharmaceuticals Initiates Phase 2a Clinical Trial of Combination Therapy in Adult Patients with Asthma
11. Quality Control: Nissan Quest to Feature micronAir(R) Combination Cabin Air Filters
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... Nov. 20, 2014 (HealthDay News) -- The cost of ... percent in recent years, climbing to more than $322 ... increases in cost were seen with prediabetes care, which ... jumped 82 percent, the researchers added. In 2012, ... totaled more than $1,000 for every American. That total ...
(Date:11/21/2014)... WOBURN, Mass. (PRWEB) November 21, 2014 ... two free workshops titled “Massachusetts Insurance Funding for Autism ... disorder (ASD) navigate their way through the insurance coverage ... covered under Massachusetts law and the most effective ways ... on Thursday, Dec. 4 from 6-8:00 p.m. at 331 ...
(Date:11/21/2014)... Recently, VogueQueen has released 18 new beach ... the coming holiday season. People who register at VogueQueen.com ... , The beach wedding dresses from VogueQueen.com have been ... for the premium quality fabrics and dedicated craftsmanship. These ... the environment, they would bring more fun to a ...
(Date:11/21/2014)... November 21, 2014 For many busy people, ... office visits and months of recovery from dental surgery that ... even at the cost of their youthful appearance. , But ... Art Institute in Oxnard and Woodland Hills, Calif., can provide ... visit, even in instances where the patient’s bone has deteriorated. ...
(Date:11/21/2014)... City, MO (PRWEB) November 21, 2014 ... to Melancholy Lift, an industry leader in the ... of people have significant feelings of sadness and ... help from traditional pharmaceutical choices. Often, prescription drugs ... of depression. Prescription drugs are expensive and require ...
Breaking Medicine News(10 mins):Health News:Cost of Diabetes Care Keeps Climbing, Report Shows 2Health News:Center for Autism and Related Disorders to Host Massachusetts Autism Insurance Workshops for Parents 2Health News:Beach Wedding Dresses on Sale for the Coming Holiday Season at VogueQueen.com 2Health News:Anacapa Dental Art Institute Prosthodontists Develop New Technique to Offer Younger Appearance in Just One Visit 2Health News:Anacapa Dental Art Institute Prosthodontists Develop New Technique to Offer Younger Appearance in Just One Visit 3Health News:Anacapa Dental Art Institute Prosthodontists Develop New Technique to Offer Younger Appearance in Just One Visit 4Health News:Anacapa Dental Art Institute Prosthodontists Develop New Technique to Offer Younger Appearance in Just One Visit 5Health News:Depression Relief Product Receives Top 5-Star Rating from TopConsumerReviews.com 2
... ... from knowledge gained learning to relieve Frozen Shoulder Syndrome without surgery or prescription drugs. ... Dallas, TX ... announced its “Sponsor Your Doctor” program. The program represents one of the ways OTZ ...
... ... Approach to Application Whitelisting by Verifying Insecure Software and Applications to Help Customers Improve ... ... Lumension , a global leader in endpoint management and security, today announced it has ...
... ... News Portal & Search Engine. , ... (PRWEB) March 30, 2010 -- eNJBusiness provides a unique ... news, events, services and products that affect the citizens of New Jersey. It is ...
... ... attorneys on elder care law, released this statement concerning a March/April AARP article entitled "Love ... couple married for 44 years was forced to divorce in order to protect their remaining ... is completely off the mark , ...
... ... New website launched to help consumers make smarter healthcare ... through discounts, transparent pricing on diagnostic tests and hospital procedures, and ... wide range of health care goods and services, including services often ...
... ... of Earth Day, Zagpromos.com and the Earth Day Network have launched an online store ... and green schools. , ... Orangeburg, NY (PRWEB) March 30, 2010 -- Zagpromos.com, a one-stop online shop for ...
Cached Medicine News:Health News:Patients Sponsor Their Chiropractors to Attend Frozen Shoulder Treatment Seminar 2Health News:Patients Sponsor Their Chiropractors to Attend Frozen Shoulder Treatment Seminar 3Health News:Lumension Partners With Citrix To Advance Desktop Virtualization Security 2Health News:Lumension Partners With Citrix To Advance Desktop Virtualization Security 3Health News:Lumension Partners With Citrix To Advance Desktop Virtualization Security 4Health News:Lumension Partners With Citrix To Advance Desktop Virtualization Security 5Health News:New Jersey's Hyperlocal Portal & Search Engine 2Health News:Prominent National Elder Law Attorney Disputes AARP Article Recommending Divorce to Afford Health Care 2Health News:Prominent National Elder Law Attorney Disputes AARP Article Recommending Divorce to Afford Health Care 3Health News:My Health and Money Helps Consumers Stretch Their Healthcare Dollars and Make Better Choices 2Health News:My Health and Money Helps Consumers Stretch Their Healthcare Dollars and Make Better Choices 3Health News:My Health and Money Helps Consumers Stretch Their Healthcare Dollars and Make Better Choices 4Health News:Zagpromos.com Launches Online Store for Earth Day Network 2Health News:Zagpromos.com Launches Online Store for Earth Day Network 3
(Date:11/21/2014)... 21, 2014   Rock Creek Pharmaceuticals, Inc., ... is scheduled to present at the Biotech Showcase™ 2015 ... on January 12-14, 2015. ... Rock Creek Pharmaceuticals, will present preclinical and clinical data ... exhibits anti-inflammatory pharmacological characteristics. Dr. Mullan will outline the ...
(Date:11/21/2014)... 21. November 2014 ... bekannt gegeben, dass die Europäische Arzneimittel-Agentur ... Kennzeichnung als Orphan-Medizinprodukt an Palovarotene vergeben ... zur Behandlung von Fibrodysplasia ossificans progressiva ... beeinträchtigende genetische Krankheit, die von schmerzhaften, ...
(Date:11/21/2014)... 20, 2014 /PRNewswire/-- CANTEL MEDICAL CORP. (NYSE: CMN ) ... Officer, will be presenting at the 26 th Annual ... in New York . The formal presentation ... ET. In addition, Mr. Krakauer and Jorgen B. Hansen ... meetings during the day. An audio webcast ...
Breaking Medicine Technology:Rock Creek Pharmaceuticals to Present at the Biotech Showcase 2015 2Rock Creek Pharmaceuticals to Present at the Biotech Showcase 2015 3Rock Creek Pharmaceuticals to Present at the Biotech Showcase 2015 4Clementia Pharmaceuticals erhält EMA-Kennzeichnung als Orphan-Medizin für Palovarotene zur Behandlung von Fibrodysplasia ossificans progressiva 2Clementia Pharmaceuticals erhält EMA-Kennzeichnung als Orphan-Medizin für Palovarotene zur Behandlung von Fibrodysplasia ossificans progressiva 3
... ATLANTA, May 25, 2011 XDATA retains Adapt ... patents and fully-functioning prototype focused on breast cancer ... and tested methods and devices for automatically capturing ... validation of the value of XDATA,s patents, leading ...
... as a sort of Huffington Post for the Medical ... offering "Your One Source For Growing Medical Marijuana" for ... worldwide. This first of its kind web ... growing Medical Marijuana and the lifestyle that has arisen ...
Cached Medicine Technology:XDATA Retains Adapt IP Ventures to Market Patents and Technology for Automated 3D Ultrasound Imaging System 2
... basic principle of a competitive enzyme immunoassay ... antigen and an labelled antigen bound to ... antiserum . The amount of enzyme conjugate ... antibody is inversely proportional to the concentration ...
... Progesterone (pregn-4-ene-3, 20-dione) is a C21 ... a double bond between C-4 and C-5 ... hormone which, in conjunction with estrogens, regulates,the ... it is particularly important in preparing the,endometrium ...
Microalbumin Turbidimetric Lipid / Protein Quantification 021-SDX001...
... known as Kininase II, is a dipeptidyl ... of at least 129,000. The structure of ... a polysaccharide residue and a zinc atom. ... types such as neuronal cells and renal ...
Medicine Products: