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ZARS Pharma Announces Worldwide License Agreement With Galderma Pharma S.A. for Pliaglis(TM), a Topical Local Anesthetic
Date:3/10/2008

SALT LAKE CITY, March 10 /PRNewswire/ -- ZARS Pharma, Inc. announced today the completion of an agreement providing Galderma Pharma S.A. the exclusive promotion and distribution rights for all markets outside the United States and Canada for Pliaglis(TM) (lidocaine and tetracaine) Cream 7%/7%, a topical anesthetic that provides effective and safe local anesthesia in patients undergoing potentially painful cosmetic and other skin treatment procedures. This agreement complements the previously announced agreement between ZARS Pharma and Galderma for the promotion and distribution rights of Pliaglis in the United States and Canada and effectively grants Galderma exclusive worldwide rights for Pliaglis.

Pliaglis has been approved by the FDA for the local anesthesia of intact skin before various superficial dermatological procedures such as dermal filler procedures, pulsed dye laser therapy, facial laser resurfacing, and laser-assisted tattoo removal and is anticipated to be the subject of marketing applications to be filed with additional regulatory authorities in key markets later in 2008. Other therapies for topical anesthesia are often characterized as having slow onset of action, sporadic and shallow anesthesia (especially in highly vascularized regions such as the face), short duration of effect and inadequate safety profiles. Pliaglis is indicated for use in adults and is applied for 20 to 30 minutes prior to procedures such as dermal filler injections or facial laser resurfacing, and for 60 minutes for procedures such as laser-assisted tattoo removal.

"We are delighted to announce the worldwide license agreement for Pliaglis with Galderma, a worldwide leader in the field of dermatology," said Robert Lippert, President and Chief Executive Officer of ZARS Pharma. "We believe that Pliaglis will become the topical anesthetic of choice for these procedures and will become an integral and important tool for physicians worldwide."

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