Navigation Links
Your immune system: On surveillance in the war against cancer
Date:5/9/2013

WINSTON-SALEM, N.C. May 9, 2013 Predicting outcomes for cancer patients based on tumor-immune system interactions is an emerging clinical approach, and new research from Wake Forest Baptist Medical Center is advancing the field when it comes to the most deadly types of breast cancer.

"We know that one function of our immune system is to detect and destroy pre-malignant cells before they can become cancer," said lead author Lance D. Miller, Ph.D., associate professor of cancer biology at Wake Forest Baptist. "However, sometimes the immune system becomes unresponsive to the presence of these cells and a tumor develops."

This unresponsiveness can be temporary, and the immune system can remain alerted to the fact that there's a problem. Immune cells can stand post along the borders of the tumor and even infiltrate the tumor core, where they may gain a better position for eventual attack. "We now have technologies that allow us to quantify aspects of this interaction and from that information we can make predictions about cancer outcomes, Miller said."

The study published online ahead of print last month in the journal Genome Biology.

This approach is known as gene expression profiling, and by studying the expression profiles of 2,000 human breast tumors, Miller and his team identified several immune gene signatures that reflect the abundance and anti-tumor properties of different types of tumor-infiltrating immune cells. They found that in certain aggressive types of breast cancer, such as basal-like or triple negative disease, these immune signatures were highly predictive of cancer recurrence years after initial treatment.

"Strikingly, the patients who seemed to benefit the most were those with highly proliferative and clinically aggressive disease," Miller said. "In these cases, high expression levels of the immune genes predicted for recurrence-free survival, while low immune gene expression predicted for
'/>"/>

Contact: Bonnie Davis
bdavis@wakehealth.edu
336-716-4977
Wake Forest Baptist Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Immune Cell Discovery May One Day Lead to Herpes Vaccine: Study
2. Temple scientists weaken HIV infection in immune cells using synthetic agents
3. Estrogen fuels autoimmune liver damage
4. New findings on the brains immune cells during Alzheimers disease progression
5. Current HPV vaccine may not help some women with immune problems
6. UCLA, Caltech research on immune-cell therapy could strengthen promising melanoma treatment
7. Immune Therapy Shows Early Promise for Advanced Leukemia
8. Study reveals potential immune benefits of vitamin D supplements in healthy individuals
9. Delgado Protocol Announces Adrenal DMG, An Amazing New Supplement Designed to Support the Immune, Circulatory and Cardiovascular Systems
10. Evidence supports blocking immune response to enhance viral therapy against solid tumors
11. Football Injuries May Trigger Harmful Immune System Response
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/2/2014)... On July 21, 2014, the Johns Hopkins Health System ... the class action lawsuit filed October 24, 2013, ... MM, on behalf of thousands of women who allegedly were ... According to The Baltimore Sun , the $190 million ... physician accused of sexual misconduct. , An investigation prompted by ...
(Date:8/1/2014)... August 02, 2014 Although most people ... their teeth and gums, it is particularly important for ... gum disease in two different ways. Hormones can affect ... difficult for these tissues to receive nutrients essential to ... the body responds to toxins produced by plaque bacteria, ...
(Date:8/1/2014)... The Judicial Panel on Multidistrict Litigation (JPML) ... caused strokes, heart attacks, and other injuries in men ... Kennelly as the transferee judge and ordered what could ... court. , As one of his first organizing acts, ... attorneys who will move the litigation forward on behalf ...
(Date:8/1/2014)... (PRWEB) August 01, 2014 Parker Waichman ... rights of victims injured by defective medical devices and ... be recalling its Ethicon surgical power morcellator devices used ... sited concerns involving the spread of cancer associated with ... dated July 31, 2014. , Johnson & Johnson ...
(Date:8/1/2014)... Almost 140 people die every year in accidents ... But there are several simple ways to ... coordinator at Cincinnati Children,s Hospital Medical Center,s Comprehensive ... news release. "As families begin to prepare ... parents and children to go over school bus ...
Breaking Medicine News(10 mins):Health News:Baltimore Lawyer Steven H. Heisler Urges Victims of OB/GYN Misconduct to Speak Out 2Health News:Baltimore Lawyer Steven H. Heisler Urges Victims of OB/GYN Misconduct to Speak Out 3Health News:Midtown Dentistry Renews Call for Women to Look After Their Dental Health 2Health News:Judge Kennelly Appoints Attorney Michelle Kranz to the Plaintiffs’ Executive Committee in the Testosterone Replacement Therapy MDL 2Health News:J&J's Ethicon Unit Recalls its Power Morcellator Devices After Warnings by Federal Regulators and Concern About Risk of Spreading Occult Cancer, Parker Waichman Comments 2Health News:J&J's Ethicon Unit Recalls its Power Morcellator Devices After Warnings by Federal Regulators and Concern About Risk of Spreading Occult Cancer, Parker Waichman Comments 3Health News:J&J's Ethicon Unit Recalls its Power Morcellator Devices After Warnings by Federal Regulators and Concern About Risk of Spreading Occult Cancer, Parker Waichman Comments 4Health News:Expert Offers School Bus Safety Tips 2
... had been in the forefront, monitoring the Herculean task of ... the documentation of the dealers. // This is being done ... is still in safe custody. 20 teams comprising of officials ... with local civic officials. ,The teams will be ...
... in Hong Kong and China have identified the deadly H5N1 ... markets of Southern China, sparking fears of bird flu pandemic//. ... hosts of the bird flu virus. This however is the ... detected among seemingly healthy chickens. Infected chickens usually die within ...
... 'in'? A new report by the American Medical Association has ... wild (s) ways!// ,A survey of 644 female college ... berserk is their take on having fun in life. Three out ... for outrageous behavior- spring break drinking meant bingeing on booze, getting ...
... for a probable influenza pandemic, and its effects on 2.6 ... concern and at a press conference , Health Minister Philippe// ... the beginning of the epidemic we're able to limit the ... plan ready, to face a worst-case possibility, of the initial ...
... It's been a long haul from a medical college here ... becoming the only Indian-born radiologist// licensed to privately practise in ... in his specialty along the way., ,He sees up ... p.m. and then writes up the reports, a task that ...
... means just tough whole-grain products. The movement has burst out ... are available that would have been unthinkable a few years ... whole-grain muesli, rubbery tofu and tasteless vegetarian cutlets, but times ... of Europe today, you will find organic ice cream and ...
Cached Medicine News:Health News:Healthy, Bird Flu Infected Chickens In Chinese Markets 2Health News:Indian-Born Doctor Diddy Shines In Germany 2Health News:Organic food loses its whole-grain image 2
(Date:7/31/2014)... July 31, 2014 Tandem Diabetes Care®, Inc. (NASDAQ: ... of the t:slim® Insulin Pump, today reported its financial results ... In comparing the second quarter of 2014 to the same ... $10.3 million from $5.5 million , t:slim Pump shipments ... In comparing six months ended June 30, 2014 to ...
(Date:7/31/2014)... SUNNYVALE, Calif., July 31, 2014 Pharmacyclics, Inc. (the ... and recent developments for the quarter ended June 30, 2014. ... Ended June 30, 2014 Revenue Total revenue for the ... $54.7 million for the quarter ended June 30, 2013 primarily ... $109.5 million. Total revenue for the six ...
(Date:7/31/2014)... SAN FRANCISCO, July 31, 2014 Nektar Therapeutics (Nasdaq: ... the second quarter ended June 30, 2014. ... were $301.4 million as compared to $309.1 million at March ... time for Nektar as we look forward to significant milestones ... W. Robin, President and Chief Executive Officer of Nektar. "The ...
Breaking Medicine Technology:Tandem Diabetes Care Reports Second Quarter 2014 Financial Results 2Tandem Diabetes Care Reports Second Quarter 2014 Financial Results 3Tandem Diabetes Care Reports Second Quarter 2014 Financial Results 4Tandem Diabetes Care Reports Second Quarter 2014 Financial Results 5Tandem Diabetes Care Reports Second Quarter 2014 Financial Results 6Pharmacyclics Reports Second Quarter 2014 Results 2Pharmacyclics Reports Second Quarter 2014 Results 3Pharmacyclics Reports Second Quarter 2014 Results 4Pharmacyclics Reports Second Quarter 2014 Results 5Pharmacyclics Reports Second Quarter 2014 Results 6Pharmacyclics Reports Second Quarter 2014 Results 7Pharmacyclics Reports Second Quarter 2014 Results 8Pharmacyclics Reports Second Quarter 2014 Results 9Pharmacyclics Reports Second Quarter 2014 Results 10Pharmacyclics Reports Second Quarter 2014 Results 11Pharmacyclics Reports Second Quarter 2014 Results 12Pharmacyclics Reports Second Quarter 2014 Results 13Pharmacyclics Reports Second Quarter 2014 Results 14Pharmacyclics Reports Second Quarter 2014 Results 15Pharmacyclics Reports Second Quarter 2014 Results 16Pharmacyclics Reports Second Quarter 2014 Results 17Pharmacyclics Reports Second Quarter 2014 Results 18Pharmacyclics Reports Second Quarter 2014 Results 19Pharmacyclics Reports Second Quarter 2014 Results 20Pharmacyclics Reports Second Quarter 2014 Results 21Pharmacyclics Reports Second Quarter 2014 Results 22Pharmacyclics Reports Second Quarter 2014 Results 23Pharmacyclics Reports Second Quarter 2014 Results 24Pharmacyclics Reports Second Quarter 2014 Results 25Pharmacyclics Reports Second Quarter 2014 Results 26Pharmacyclics Reports Second Quarter 2014 Results 27Pharmacyclics Reports Second Quarter 2014 Results 28Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 2Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 3Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 4
... ANDOVER, Mass., June 23, 2011 Smith & Nephew, Inc., ... SNN ) (London Stock Exchange: SN) announced today ... found in Smith & Nephew,s favor that Arthrex, Inc., (Naples, ... exclusively licensed to Smith & Nephew. The ...
... Mr. Ronald L. Chez, a private investor, filed an amended ... RGEN ) with the SEC. RepliGen Corporation ... integrated company by developing and marketing innovative drugs that deliver ... and gastroenterology.  RepliGen has a core competency in the development ...
Cached Medicine Technology:Smith & Nephew Endoscopy Awarded $85 Million in Patent Infringement Case Against Arthrex, Inc. 2Smith & Nephew Endoscopy Awarded $85 Million in Patent Infringement Case Against Arthrex, Inc. 3
Lacrimal Cannulas, 19 g. shaft tapering to 23 g. curved cannula. Overall length 37.7 mm. 5/box....
Anterior Chamber Needle, 27 g. Angled. 5 mm angled tip. Overall length 20 mm. 5/box....
Anterior Chamber Needle, 20 g. Angled. 7 mm angled tip. Overall length 23 mm. 5/box....
Retinal Hydrodissection Cannula. 20 gauge shaft tapers to 41 gauge I.D. flexible tip. Packaged sterile. 5/Box....
Medicine Products: