Navigation Links
Your immune system: On surveillance in the war against cancer
Date:5/9/2013

WINSTON-SALEM, N.C. May 9, 2013 Predicting outcomes for cancer patients based on tumor-immune system interactions is an emerging clinical approach, and new research from Wake Forest Baptist Medical Center is advancing the field when it comes to the most deadly types of breast cancer.

"We know that one function of our immune system is to detect and destroy pre-malignant cells before they can become cancer," said lead author Lance D. Miller, Ph.D., associate professor of cancer biology at Wake Forest Baptist. "However, sometimes the immune system becomes unresponsive to the presence of these cells and a tumor develops."

This unresponsiveness can be temporary, and the immune system can remain alerted to the fact that there's a problem. Immune cells can stand post along the borders of the tumor and even infiltrate the tumor core, where they may gain a better position for eventual attack. "We now have technologies that allow us to quantify aspects of this interaction and from that information we can make predictions about cancer outcomes, Miller said."

The study published online ahead of print last month in the journal Genome Biology.

This approach is known as gene expression profiling, and by studying the expression profiles of 2,000 human breast tumors, Miller and his team identified several immune gene signatures that reflect the abundance and anti-tumor properties of different types of tumor-infiltrating immune cells. They found that in certain aggressive types of breast cancer, such as basal-like or triple negative disease, these immune signatures were highly predictive of cancer recurrence years after initial treatment.

"Strikingly, the patients who seemed to benefit the most were those with highly proliferative and clinically aggressive disease," Miller said. "In these cases, high expression levels of the immune genes predicted for recurrence-free survival, while low immune gene expression predicted for
'/>"/>

Contact: Bonnie Davis
bdavis@wakehealth.edu
336-716-4977
Wake Forest Baptist Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Immune Cell Discovery May One Day Lead to Herpes Vaccine: Study
2. Temple scientists weaken HIV infection in immune cells using synthetic agents
3. Estrogen fuels autoimmune liver damage
4. New findings on the brains immune cells during Alzheimers disease progression
5. Current HPV vaccine may not help some women with immune problems
6. UCLA, Caltech research on immune-cell therapy could strengthen promising melanoma treatment
7. Immune Therapy Shows Early Promise for Advanced Leukemia
8. Study reveals potential immune benefits of vitamin D supplements in healthy individuals
9. Delgado Protocol Announces Adrenal DMG, An Amazing New Supplement Designed to Support the Immune, Circulatory and Cardiovascular Systems
10. Evidence supports blocking immune response to enhance viral therapy against solid tumors
11. Football Injuries May Trigger Harmful Immune System Response
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2015)... 2015 The Hermitage has responded to ... violations that date back to 2012. The mitigation work ... soon as it was approved in the summer of ... the allegations we agreed to 100% mitigation at our ... Holding Company. , Barnes further added, "we were surprised ...
(Date:2/27/2015)... UAS LifeSciences, will showcase their new chewable adult ... March 6 to 8 in Anaheim, CA. ... down best tasting probiotic in the business, Adult Cubes. ... Vitamin C. This is a companion product to our ... Living’s Supplement Award and Taste for Life’s Essential Supplements ...
(Date:2/27/2015)... Park, Kansas (PRWEB) February 27, 2015 ... ( http://www.cdc.gov/datastatistics/2008/brainInjuries ), more than 38 million children ... States each year. As a result of ... reaching capacity maximizing their equipment and square footage ... suspended athletic equipment. , "Athletic ...
(Date:2/27/2015)... 2015 Leading up to the White ... PartnerTech Inc. President, Gary Bruce, joined with other ... for the TechAmerica DC Fly-In. This is a ... technology along with the opportunity to have a voice ... products, evidenced by their current projects with NanoLumens ...
(Date:2/27/2015)... Javon Bea Mercy Health System President ... and open to the public, is held the second ... Mall Food Court, 2500 Milton Ave. Monthly meetings include ... and an educational health-related presentation. Participants receive a free ... for Health. , March 10: Using exercise to feel ...
Breaking Medicine News(10 mins):Health News:Southern Vermont's Hermitage Club Announces Statement Regarding Vermont Attorney General Lawsuit for Permit Violations 2Health News:UAS LifeSciences to Launch UP4 Adult Cubes at Expo West 2Health News:Rise of Students Participating in Sports Creates Need for Preventative Maintenance to Gymnasium Equipment in Athletic Facilities 2Health News:Rise of Students Participating in Sports Creates Need for Preventative Maintenance to Gymnasium Equipment in Athletic Facilities 3Health News:PartnerTech Joins Technology Association of Georgia for TechAmerica DC Fly-In 2Health News:PartnerTech Joins Technology Association of Georgia for TechAmerica DC Fly-In 3
... is good for the heart. A recent study undertaken by Robert// ... School has found that by eating fish regularly, the risk ... a lower risk of cardiovascular problems. , ,The substance ... lean varieties such as salmon. The study used more than 3,000 ...
... A large new study reports that Vitamin E is unlikely ... the risk of heart attacks and stroke in older women. ... Pauling Institute at Oregon State University and an expert on ... to reduce the risk of heart and other serious degenerative ...
... age of 60 and above can have less back pain ... back supporting device and doing some special exercises. ,In ... said that the new specially weighed back support device can ... extensive improvements in strength for the women who had suffered ...
... Prayers can help heart patients in the recovery process ... // University Medical Centre. Researchers said cardiac patients using ... heart failure, post-procedural ischemia or heart attack,than those without ... to April 1998 with symptoms of acute coronary ischemia. ...
... and colleagues compared their Cell culture small pox vaccine// ... vaccine. Small pox vaccine currently used is a live, ... produces adverse effects in vaccinated, 15-42 develop serious or ... 2 people every million die because of this vaccine. ...
... of osteoporosis is useful, but changes in bone// mineral ... are anti-resorptive agents that prevent bone breakdown. ,For ... that enhances bone formation is preferable, and this is ... (PTH). However, the use of PTH is limited by ...
Cached Medicine News:Health News:The Benefits of Strontium in the treatment for Osteoporosis Questioned 2
(Date:2/26/2015)... , Feb. 26, 2015  MEI Pharma, Inc. (Nasdaq: ... development of novel therapies for cancer, announced today that ... will present at the Cowen and Company 35 th ... 10:40 a.m. Eastern time from the Boston Marriott Copley Place. ... www.meipharma.com . A replay will be available approximately one ...
(Date:2/26/2015)... , Feb. 26, 2015 Ultrasound ... at the Clearwater Beach Hilton to provide the ... to plant reliability professionals from around the world. ... stellar collection of leaders in the field of ... demand for excellence continues with this year,s conference. ...
(Date:2/26/2015)... , Feb. 26, 2015   Coverall North ... franchised businesses, today celebrates 30 Years of Clean, a ... anniversary. Coverall started in 1985 as a ... and is now a leading global brand ... Coverall,s passion and mission have remained consistent: To promote ...
Breaking Medicine Technology:MEI Pharma to Present at Cowen and Company Health Care Conference 2MEI Pharma to Present at Cowen and Company Health Care Conference 3UE Systems Renowned "Ultrasound World" Conference Celebrates its 11th Year 2Coverall Celebrates 30 Years of Clean 2Coverall Celebrates 30 Years of Clean 3
... response roller-pumps, the REVOLUTION provides continuous ... field. Furthermore the dual pump system ... intra-articular pressure and flow rate. , ... controls, providing the surgeon with the ...
... Burner captures still images and full ... archives allows for multiple cases to ... unit provides software burned to every ... and editing. Compatible with DICOM and ...
The Sony DSR20-MD Grade Digital Video Player/Recorder represents a giant leap in digital technology. , ,This equipment is intended to be used by physicians who teach or present medical techniques...
Colour video monitors....
Medicine Products: