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Young patients with metastatic colorectal cancer are at high risk of disease progression and death
Date:9/27/2013

the comprehensive nature of the study, more research will be required to identify why colorectal cancer in younger people appears to be more aggressive. "Further studies identifying biological differences are warranted," says Dr Lieu. He and his group are currently collaborating along these lines with a research group at the University of Texas MD Anderson Cancer Center (Texas, USA).

ECCO President, Professor Cornelis van de Velde, commented: "While colorectal cancer overwhelmingly occurs in older people, we must not forget that people younger than 50 can develop it too. The study by Lieu and his colleagues is important as it shows that these younger patients may have a worse prognosis if their disease has metastasised. Doctors and patients need to be aware of this so that they are alert to the early symptoms of colorectal cancer, and treatment can be given before the disease has started to spread."

ESMO spokesperson, Professor Erika Martinelli, Assistant Professor in Medical Oncology at Seconda Universit Studi di Napoli Policlinico Federico II, Naples, Italy, commented: "Considerable controversy exists concerning the outcome of younger patients with colorectal cancer and it is a critical topic because the incidence of this cancer is increasing in the younger population. Dr Lieu and his colleagues have contributed important scientific evidence from a worldwide collaboration of clinicians and scientists specialising in gastrointestinal cancer, and they have confirmed that patients younger than 40 have a worse prognosis. These patients have poor overall survival and progression-free survival, and this was not influenced by sex or performance status.

"The conclusions are intriguing because the study has been performed on a large case series of patients (the ARCAD database is one of the largest in gastrointestinal oncology), reinforcing the concept that younger people diagnosed with colorectal cancer survive less well, in spite of being in be
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Contact: José Abad
ecco2013press@gmail.com
ECCO-the European CanCer Organisation
Source:Eurekalert

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