Navigation Links
You can teach an old dog new tricks: anti-malarial prevents cancer in mice
Date:12/20/2007

New data generated by a team of researchers from St Jude Childrens Research Hospital, Memphis, and Scripps Research Institute, Jupiter, have indicated that the antimalarial drug chloroquine effectively prevents cancer in mouse models of two distinct human cancer syndromes, Burkitt lymphoma and ataxia telangiectasia. As discussed in the accompanying commentary by Chi Dang, from Johns Hopkins University School of Medicine, Baltimore, these results complement an old epidemiology study suggesting that malarial prophylaxis with chloroquine diminished the incidence of Burkitt lymphoma.

In the study, chloroquine was shown to inhibit the development of Myc-induced lymphomas (a mouse model of Burkitt lymphoma) and to inhibit the development of lymphomas in ATM-deficient mice (a mouse model of ataxia telangiectasia). By contrast, chloroquine did not inhibit the development of lymphomas in p53-deficient mice. Further analysis indicated that chloroquine induced cellular features of autophagy (self-eating) and mediated its effects by inducing lysosomal stress and provoking a p53-dependent cell death. The authors therefore suggested that modulating autophagy, either using chloroquine or other approaches, might provide a new avenue for the development of anticancer therapeutics.


'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related medicine news :

1. Struggling male readers respond better to female teachers
2. Tips for Parents: Teaching Children to Resolve Conflicts
3. Vatican Affirms Church Teaching on Nutrition and Hydration for Individuals In Vegetative State
4. New Seminar Series from Activator Methods Teaches Doctors a Unique Approach to Improving Nations Chiropractic Care: Focus on the Patients
5. 10th Anniversary of Revolutionary Teaching Approach that Offers the Severely Disabled the Gift of Self-Expression - Through Painting
6. Curtailing School Violence: National Mental Health Experts Outline What Teachers Need to Know
7. TriWest Contributes $25,000 to Iowa National Guard Fund and Sponsors Education for Teachers of Military Children
8. A fresh look at existing therapies: Researchers explore ways to teach approved drugs new tricks
9. Safe Crossing Week 2007 Teaches Kids How to Behave Safely Around Trains
10. Inspirational Medical Teachers Honored with Mentor Awards from the American Society of Hematology
11. This Holiday Season, Teach Your Kids the Science of How Drinking Alcohol Can Hurt Them
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... ... May 03, 2016 , ... ... selected by Tidelands Health, a three hospital system in South Carolina, to provide ... the lookout for technology that enhances communication, drives workflow efficiencies and improves provider ...
(Date:5/3/2016)... ... ... injury law firm Monge & Associates is honoring Moms in the time leading ... their Mother or any other mother figure. , According to law firm founder, Scott Monge, ... to say, “we are choosing to do this by giving free roses to those who ...
(Date:5/3/2016)... ... May 03, 2016 , ... Ogawa World USA introduced ... user friendly Samsung tablet and exclusive Smart Application. The Smart 3D combines the best ... massage with a customized user profile and specialized massage program, each user has a ...
(Date:5/3/2016)... Toronto, ON (PRWEB) , ... May 03, 2016 ... ... been recognized as one of Canada’s top Information and Communication Technology (ICT) companies ... top Canadian and Multinational ICT companies operating in Canada, as ranked by revenue. ...
(Date:5/3/2016)... ... May 03, 2016 , ... Huntington Beach orthopedic doctor , Dr. Rick ... can be used to diagnose and treat joint problems. During this procedure, Dr. Pospisil ... a special lighting system and lens that illuminate and magnify the various structures in ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... 3, 2016   BIOTRONIK , a leader ... Food and Drug Administration (FDA) approval of Iperia ... heart failure patients with access to diagnostic magnetic ... remote monitoring with daily automatic transmission and closed ... in response to physiological demands. ...
(Date:5/3/2016)... OSWEGO, Ore. , May 3, 2016   ... the importance of extending care beyond the implant at ... Sessions, May 4-7 in San Francisco ... with continually delivering the highest quality of patient care ... patients are cared for each and every tomorrow," said ...
(Date:5/3/2016)... 3, 2016 Pharmaceutical giant Johnson ... to a woman who says its talc-based powder products ... Gloria Ristesund $5 million in compensatory damages and ... http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , This is ... company. In February, the same court awarded $72 million ...
Breaking Medicine Technology: