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You are what your father ate
Date:12/23/2010

WORCESTER, Mass. Scientists at the University of Massachusetts Medical School and the University of Texas at Austin have uncovered evidence that environmental influences experienced by a father can be passed down to the next generation, "reprogramming" how genes function in offspring. A new study published this week in Cell shows that environmental cuesin this case, dietinfluence genes in mammals from one generation to the next, evidence that until now has been sparse. These insights, coupled with previous human epidemiological studies, suggest that paternal environmental effects may play a more important role in complex diseases such as diabetes and heart disease than previously believed.

"Knowing what your parents were doing before you were conceived is turning out to be important in determining what disease risk factors you may be carrying," said Oliver J. Rando, MD, PhD, associate professor of biochemistry & molecular pharmacology at UMMS and principal investigator for the study, which details how paternal diet can increase production of cholesterol synthesis genes in first-generation offspring.

The human genome is often described as the set of instructions that govern the development and functioning of life. It's not surprising, then, that most contemporary genetic research focuses on understanding and cataloging how mutations and changes to our DNAthe basis of those "instructions"cause disease and impact health. A number of recent studies, however, have begun to draw attention to the role epigenetic inheritance inherited changes in gene expression caused by mechanisms other than changes in the underlying DNA sequence may play in a host of illnesses. "A major and underappreciated aspect of what is transmitted from parent to child is ancestral environment," said Dr. Rando. "Our findings suggest there are many ways that parents can 'tell' their children things."

To test their hypothesis that environmental influences experienced by the fath
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Contact: Jim Fessenden
james.fessenden@umassmed.edu
774-823-0405
University of Massachusetts Medical School
Source:Eurekalert

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