Navigation Links
Yosef Shiloh, Ph.D., receives the 51st Annual AACR G.H.A. Clowes Memorial Award
Date:3/25/2011

ORLANDO, Fla. Yosef Shiloh, Ph.D., a David and Inez Myers professor in cancer research in the department of Human Molecular Genetics and Biochemistry in the Sackler School of Medicine at Tel Aviv University, Israel, will receive the 51st Annual AACR G.H.A. Clowes Memorial Award for his studies of the cellular DNA damage response and the rare genomic instability syndrome ataxia-telangiectasia (A-T).

"Dr. Shiloh is an international leader in the study of A-T, and his identification and cloning of the A-T gene provided for the first time a definitive diagnosis for so many who had gone without one," said Margaret Foti, Ph.D., M.D. (h.c.), chief executive officer of the AACR. "This discovery, along with his subsequent work, has played a critical role in increasing our understanding of DNA damage response and repair, which has important implications for cancer and other diseases. Dr. Shiloh is a truly exceptional scientist and we congratulate him on receiving the G.H.A. Clowes Memorial Award."

Patients with A-T exhibit progressive neurodegeneration, immunodeficiency, striking cancer predisposition and chromosomal fragility. The disease is caused by a profound defect in a major mechanism that maintains genomic stability the cellular response to DNA double strand breaks.

For over 30 years Shiloh has been investigating A-T and the defect in the DNA damage response that leads to this disease. He changed the field when his lab identified the A-T gene in 1995 and successfully cloned it, calling it ataxia-telangiectasia mutated (ATM). The identification of the ATM gene revolutionized the field, opening many new avenues of inquiry and allowing research to race forward.

Since then, the Shiloh laboratory has expanded its studies to the mode of action of the ATM gene product the ATM protein kinase and the extensive signaling network that it activates in response to DNA damage. A leader in this field, Shiloh's work has made a major impact on the scientific understanding of the cellular response to genotoxic stress. This, in turn, has led to the discovery of many new genes and processes with critical roles in human biology and cancer.

Shiloh earned an undergraduate degree from The Technion - Israel Institute of Technology in 1974, a Master of Science in human genetics from The Hebrew University of Jerusalem in 1977 and his doctorate in human genetics from The Hebrew University of Jerusalem in 1983.

From 1983 to 1985 he was a research fellow at Harvard Medical School and The Children's Hospital of Boston. He joined Tel Aviv University in 1985 as a senior lecturer of human genetics and was an associate professor there from 1989 to 1995. He has been a professor of human genetics at Tel Aviv University Sackler School of Medicine since 1995 and served as chairman of the department of human genetics and molecular medicine from 2002 through 2005.

Shiloh is also research professor of the Israel Cancer Research Fund, and a member of the American Association of Cancer Research and numerous editorial boards and organizations, among them the Israel National Academy of Sciences and Humanities, the American Society of Human Genetics, the European Molecular Biology Organization, the European Association of Cancer Research, and the Human Genome Organization. His work has earned him many awards and honors, including the Israel Prize, the American Cancer Society International Research Fellowship, Teva Pharmaceutical Industries Prize in Biomedical Research, the Fogarty Scholarship at the National Institutes of Health and the EMET Prize in Life Sciences, awarded by The A.M.N. Foundation for the Advancement of Science, Art and Culture and the Prime Minister of the State of Israel.

The American Association for Cancer Research and Eli Lilly and Company established the G.H.A. Clowes Memorial Award in 1961 to honor G.H.A. Clowes, a founding member of the AACR. This honor recognizes and individual with outstanding recent accomplishments in basic cancer research.


'/>"/>

Contact: Michele Sharp
Michele.Sharp@aacr.org
267-646-0622
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. Yosef Shiloh, Ph.D., receives the 51st Annual AACR G.H.A. Clowes Memorial Award
2. Donald A. Deieso, Ph.D., Chairman & CEO, PeriGen, Inc. Named Ernst & Young Entrepreneur Of The Year 2010 Award Finalist
3. AnaLisa DiFeo, Ph.D., recognized with the Liz Tilberis Scholarship
4. Pier Paolo Pandolfi, M.D., Ph.D., to receive Pezcoller-AACR International Award for Cancer Research
5. Susan Band Horwitz, Ph.D., receives AACR Award for Lifetime Achievement in Cancer Research
6. Susan Band Horwitz, Ph.D., of Einstein, receives lifetime achievement award in cancer research
7. 2010 AAAS Philip Hauge Abelson Award presented to the Honorable Rush Holt, Ph.D., for supporting science in Congress
8. Susan Band Horwitz, Ph.D., receives Eighth Annual AACR Award for Lifetime Achievement in Cancer Research
9. NACDD Receives Two-Year Grant From Merck & Co., Inc. to Improve Diabetes Education
10. Dr Yaghouti of Global Laser Vision Receives Patient's Choice Award for 2009
11. UT researcher receives $2.4 million to research obesity, high-risk pregnancy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is helping to ... app. The fitness app plans to fix the two major problems leading the fitness industry ... fits all type program , They don’t eliminate all the reasons people quit ...
(Date:6/25/2016)... ... ... "With 30 hand-drawn hand gesture animations, FCPX users can easily customize each ... Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures into hand ... select a ProHand generator and drag it above media or text in the Final ...
(Date:6/25/2016)... ... , ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter ... bar too high can result in disappointment, perhaps even self-loathing. However, those who set ... , Research from PsychTests.com reveals that behind the tendency to set low ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary ... Dallas that it will receive two significant new grants to support its work ... marked its 25th anniversary by recognizing patients, medical professionals and scientists for their ...
(Date:6/24/2016)... ... 24, 2016 , ... People across the U.S. are sharpening their pencils and ... essay contest in which patients and their families pay tribute to a genetic counselor ... National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... and INDIANAPOLIS , June 23, 2016 ... Lilly Diabetes Tomorrow,s Leaders Scholarship is any indication, the ... announced today online at www.diabetesscholars.org by the ... diabetes stand in the way of academic and community ... Foundation,s scholarship program since 2012, and continues to advocate ...
(Date:6/23/2016)... 2016  Guerbet announced today that it has been ... Award . One of 12 suppliers to ... its support of Premier members through exceptional local customer ... commitment to lower costs. ... our outstanding customer service from Premier," says Massimo ...
(Date:6/23/2016)... , June 23, 2016  Experian Health, ... and transforming the patient payment and care ... innovative new products and services that will ... revenue cycle offerings. These award-winning solutions will ... workflows, remain compliant in an ever-changing environment ...
Breaking Medicine Technology: