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Yosef Shiloh, Ph.D., receives the 51st Annual AACR G.H.A. Clowes Memorial Award
Date:3/25/2011

ORLANDO, Fla. Yosef Shiloh, Ph.D., a David and Inez Myers professor in cancer research in the department of Human Molecular Genetics and Biochemistry in the Sackler School of Medicine at Tel Aviv University, Israel, will receive the 51st Annual AACR G.H.A. Clowes Memorial Award for his studies of the cellular DNA damage response and the rare genomic instability syndrome ataxia-telangiectasia (A-T).

"Dr. Shiloh is an international leader in the study of A-T, and his identification and cloning of the A-T gene provided for the first time a definitive diagnosis for so many who had gone without one," said Margaret Foti, Ph.D., M.D. (h.c.), chief executive officer of the AACR. "This discovery, along with his subsequent work, has played a critical role in increasing our understanding of DNA damage response and repair, which has important implications for cancer and other diseases. Dr. Shiloh is a truly exceptional scientist and we congratulate him on receiving the G.H.A. Clowes Memorial Award."

Patients with A-T exhibit progressive neurodegeneration, immunodeficiency, striking cancer predisposition and chromosomal fragility. The disease is caused by a profound defect in a major mechanism that maintains genomic stability the cellular response to DNA double strand breaks.

For over 30 years Shiloh has been investigating A-T and the defect in the DNA damage response that leads to this disease. He changed the field when his lab identified the A-T gene in 1995 and successfully cloned it, calling it ataxia-telangiectasia mutated (ATM). The identification of the ATM gene revolutionized the field, opening many new avenues of inquiry and allowing research to race forward.

Since then, the Shiloh laboratory has expanded its studies to the mode of action of the ATM gene product the ATM protein kinase and the extensive signaling network that it activates in response to DNA damage. A leader in this field, Shiloh's work has made a major impa
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Contact: Michele Sharp
Michele.Sharp@aacr.org
267-646-0622
American Association for Cancer Research
Source:Eurekalert

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