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York physicists offer novel insight into experimental cancer treatment
Date:7/15/2013

Physicists from the University of York have carried out new research into how the heating effect of an experimental cancer treatment works.

Magnetic hyperthermia is viewed as an attractive approach for the treatment of certain cancers as it has no known side effects compared to more conventional therapies such as chemotherapy. It is particularly suitable for the treatment of prostate cancer and brain tumours. However, until now there has been no clear theoretical understanding of how it actually works.

Treatment by magnetic hyperthermia involves injecting magnetic nanoparticles directly into a tumour then placing the patient in a machine which produces an alternating magnetic field. The nanoparticles oscillate and heat is produced inside the tumour tissue. When the temperature rises above 42C cells begin to die. This heating process has been demonstrated to reduce tumour size.

The study, by researchers from the University of York's Department of Physics and Liquids Research Ltd, of Bangor, North Wales, showed that the amount of heat generated by magnetic nanoparticles can be understood when both the physical and hydrodynamic size distributions for the samples are known to high accuracy.

The results of the study are published in the Journal of Physics D: Applied Physics as a fast track communication.

Lead author Dr Gonzalo Vallejo-Fernandez, from York's Department of Physics, said: "While clinical trials have shown the potential of magnetic nanoparticles for cancer treatment, the mechanisms by which the heat is generated have not been fully understood. This understanding is critical to produce particles with optimised properties for specific applications at minimal dose."

Previously the heat generated was impossible to predict as several mechanisms were involved. The new work has identified and quantified the mechanisms so that work can now begin to determine the dosage required for effective treatment.

Dr Vallejo-Fernandez s
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Contact: Caron Lett
caron.lett@york.ac.uk
44-019-043-22029
University of York
Source:Eurekalert

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