Navigation Links
York physicists offer novel insight into experimental cancer treatment
Date:7/15/2013

Physicists from the University of York have carried out new research into how the heating effect of an experimental cancer treatment works.

Magnetic hyperthermia is viewed as an attractive approach for the treatment of certain cancers as it has no known side effects compared to more conventional therapies such as chemotherapy. It is particularly suitable for the treatment of prostate cancer and brain tumours. However, until now there has been no clear theoretical understanding of how it actually works.

Treatment by magnetic hyperthermia involves injecting magnetic nanoparticles directly into a tumour then placing the patient in a machine which produces an alternating magnetic field. The nanoparticles oscillate and heat is produced inside the tumour tissue. When the temperature rises above 42C cells begin to die. This heating process has been demonstrated to reduce tumour size.

The study, by researchers from the University of York's Department of Physics and Liquids Research Ltd, of Bangor, North Wales, showed that the amount of heat generated by magnetic nanoparticles can be understood when both the physical and hydrodynamic size distributions for the samples are known to high accuracy.

The results of the study are published in the Journal of Physics D: Applied Physics as a fast track communication.

Lead author Dr Gonzalo Vallejo-Fernandez, from York's Department of Physics, said: "While clinical trials have shown the potential of magnetic nanoparticles for cancer treatment, the mechanisms by which the heat is generated have not been fully understood. This understanding is critical to produce particles with optimised properties for specific applications at minimal dose."

Previously the heat generated was impossible to predict as several mechanisms were involved. The new work has identified and quantified the mechanisms so that work can now begin to determine the dosage required for effective treatment.

Dr Vallejo-Fernandez said: "Through our study we have produced the first comprehensive assessment of how the heating effect in magnetic hyperthermia works. We are now in a position where we can do further work to calculate accurately the dose of magnetic nanoparticles and length of treatment required."

For the study, the researchers used magnetic nanoparticles produced by a new technique by Liquids Research Ltd, which was developed under the EU project MULTIFUN (Multifunctional Nanotechnology for Selective Detection and Treatment of Cancer). The nanoparticles are very uniform in size and well separated, which enabled detailed experiments to be performed which broadly confirmed the accuracy of the calculations.

Dr Vijay Patel, Director of Liquids Research Ltd, said: "The development of this new theory coincided with our work on the new process to fabricate the nanoparticles enabling us to 'design' almost ideal particles for this application."


'/>"/>

Contact: Caron Lett
caron.lett@york.ac.uk
44-019-043-22029
University of York
Source:Eurekalert

Related medicine news :

1. Seeing is believing: Biologists and physicists produce revealing images of cell organization, behavior
2. Experts Offer Advice After Yankee Pitchers Trampoline Injury
3. Mayo Clinic offers newly approved treatment for acid reflux disease
4. Here Are Fruits, Veggies That Offer Best Bang for Your Buck
5. Wilderness Medicine founder offers health tips for summer season
6. Ice Cream Headaches Might Offer Clues to Migraines
7. Botox Offers Little Relief for Migraine, Study Finds
8. Novel drug candidates offer new route to controlling inflammation
9. Prosthetic retina offers simple solution to restoring sight
10. Study Offers Ways to Decrease Use of Restraints at Nursing Homes
11. Cabazitaxel can offer an advantage in certain patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/20/2017)... ... June 20, 2017 , ... AMC Health , the leading provider ... the clinical trials market. Similar to its approach in demonstrating positive outcomes in the ... marketplace by proving the value of eVisits to support virtual studies. , ...
(Date:6/20/2017)... BC (PRWEB) , ... June 20, 2017 , ... As ... community on the link between stroke and gum disease. Those with bleeding gums in ... If left untreated, this condition can lead to heart disease, stroke and diabetes. Drs. ...
(Date:6/20/2017)... (PRWEB) , ... June 20, 2017 , ... ... polyA sites. To understand their regulatory principles, the research team developed expressRNA, a ... and RNA motif analyses. This reveals at nucleotide resolution the ‘RNA maps’, which ...
(Date:6/20/2017)... ... June 20, 2017 , ... BrightStar Care Centerville/South Dayton, ... by the Joint Commission, which accredits and certifies nearly 21,000 healthcare organizations and ... as a symbol of quality that reflects an organization’s commitment to meeting certain ...
(Date:6/20/2017)... ... June 20, 2017 , ... International water advocate ... Sharon Kleyne Hour Power of Water, Global Climate Change and Your Health on ... water crisis and how it affects the human eyes. , According to ...
Breaking Medicine News(10 mins):
(Date:6/12/2017)... , June 12, 2017 Kineta, Inc., a biotechnology ... Kineta Vice President of R&D and Head of ... Pandemic Preparedness for the Northwest and Beyond meeting ... on June 14, 2017 from 8:30-10:30 AM PDT at the ... Dr. Bedard will be joined by other ...
(Date:6/8/2017)... , June 8, 2017  Less than a month ... more than 200,000 companies, including hospital networks, in over ... as one of the largest online extortion attempts ever ... healthcare market, it is imperative that providers understand where ... data from this — and many other very real ...
(Date:6/7/2017)... Infusion Group, a brand of Diplomat Pharmacy, Inc. (NYSE: DPLO), has ... location. The Iowa facility ... cleanroom—the standard needed to compound intravenous (IV) nutrition formulations. A cleanroom ... "Our new cleanroom will allow us ... Iowa patients," said Phil Rielly , Diplomat ...
Breaking Medicine Technology: