Navigation Links
Yeast unravels effects of chemotherapy drugs
Date:9/9/2009

Until now, the mode of action of nitrogen-containing bisphosphonate (N-BP) cancer drugs, used to relieve bone pain and to prevent skeletal complications in bone metastasis, has been almost entirely unknown. Researchers writing in BioMed Central's open access journal Genome Biology have used 'barcoded' yeast mutants to identify new biological processes involved in the cellular response to N-BPs, opening up opportunities for the development of new anticancer drugs.

Daniela Delneri, from the University of Manchester, UK, worked with Gianluca Tell and an Italian team of researchers to carry out the experiments. Delneri said, "We discovered two novel biological processes involved in the cytotoxic effects of the N-BPs, DNA damage and microtubule assembly, and, thanks to the novel 'barcode' approach, these could be linked directly to the responsible genes, DBF4 and TBCB."

The researchers used a collection of thousands of yeast mutants, each identified by a unique molecular barcode. By evaluating which yeasts grew best when exposed to N-BPs, they were able to identify potential drug targets and gain insight into the molecular changes occurring in cells exposed to such drugs. Speaking about the results, Delneri said, "Neither DBF4 nor TBCB have been described before as N-BP targets, and these findings may open up new opportunities for the development of new compounds with antitumor activity".


'/>"/>

Contact: Graeme Baldwin
graeme.baldwin@biomedcentral.com
44-203-192-2165
BioMed Central
Source:Eurekalert

Page: 1

Related medicine news :

1. Nuvilex Cites Study that Suggests Red Yeast Rice, an Active Ingredient in Cinnechol, Can Help to Improve Cardiovascular Health
2. Study Links Sugar Production in Yeast Cells to Longevity
3. How yeast is helping us to understand Parkinsons Disease
4. Yeast mimics severity of mutations leading to fatal childhood illness
5. Genetic Approach Boosts Yeast Infection Treatment
6. Fish oil and red yeast rice studied for lowering blood cholesterol
7. New research on mutation in yeast can enhance understanding of human diseases
8. Chinese Red Yeast Rice May Prevent Heart Attack
9. Report raises C. diff concerns; yeast-based probiotic shown to help significantly reduce recurrence
10. Yeast gives rise to new concept: cell fuel is brains behind division
11. Penn researchers find potential in yeast for selecting Lou Gehrigs disease drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... ... February 11, 2016 , ... The annual list showcases ... evaluation of DataPoint’s team dedication and commitment to the SharePoint ecosystem. A ... annual list. The panel’s goal is to recognize and promote technology entrepreneurship. , ...
(Date:2/11/2016)... (PRWEB) , ... February 11, 2016 , ... Be ... new office in the heart of Old Town at 108 South Columbus St, Suite ... businesses the highest level of medical care in the convenience of their homes, offices ...
(Date:2/11/2016)... ... February 11, 2016 , ... Hoggan ... force gauges used in physical therapy, occupational therapy and sports medicine clinics, hospitals, ... cord exercise and therapy, introduces its new microFET Digital Pinch Gauge. , ...
(Date:2/11/2016)... , ... February 11, 2016 , ... ... become more actively engaged in health and wellness best practices in the past ... riding this trend. February is American Heart Month, which acts as an exceptional ...
(Date:2/11/2016)... ... February 11, 2016 , ... Research led by Providence ... several common cancer screenings, especially among women. Cancer screenings are often the best ... , The study,“What Does Medicaid Expansion Mean for Cancer Screening and Prevention: Results ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... India , February 11, 2016 ... Global Autoclave Market Report 2016 research report provides ... key regions, development status with crucial statistical data ... --> http://www.deepresearchreports.com/142870.html . --> Complete ... profiling 19 companies and supported with 296 tables ...
(Date:2/10/2016)... Feb. 11, 2016  QT Vascular Ltd., together with ... together with its subsidiaries, the "Group"), is pleased ... with AngioScore, Inc. ("ÄngioScore") (now owned by Spectranetics ... the United States Court of ... reversed an earlier district court order (the "DCO").   ...
(Date:2/10/2016)... Inc. (Nasdaq: GHDX ) today reported financial results and ... --> --> Revenue was $74.5 ... in the fourth quarter of 2014, an increase of 8 percent. ... the same period in the prior year. --> ... fourth quarter of 2015, an increase of 9 percent compared with ...
Breaking Medicine Technology: