Navigation Links
Yeast model offers clues to possible drug targets for Lou Gehrig's disease, study shows
Date:10/28/2012

STANFORD, Calif. Amyotrophic lateral sclerosis, also called Lou Gehrig's disease, is a devastatingly cruel neurodegenerative disorder that robs sufferers of the ability to move, speak and, finally, breathe. Now researchers at the Stanford University School of Medicine and San Francisco's Gladstone Institutes have used baker's yeast a tiny, one-celled organism to identify a chink in the armor of the currently incurable disease that may eventually lead to new therapies for human patients.

"Even though yeast and humans are separated by a billion years of evolution, we were able to use the power of yeast genetics to identify an unexpected potential drug target for ALS," said Aaron Gitler, PhD, an associate professor of genetics at Stanford. "Many neurodegenerative disorders such as ALS, Parkinson's and Alzheimer's exhibit protein clumping or misfolding within the neurons that is thought to either cause or contribute to the conditions. We are trying to figure out why these proteins aggregate in neurons in the brain and spinal cord, and what happens when they do."

In 2008, Gitler received a New Innovator award from the National Institutes of Health to use yeast as a model for understanding human neurodegenerative diseases and as a way to identify new targets for drug development.

Gitler is the co-senior author of the research, which will be published online Oct. 28 in Nature Genetics. Robert Farese, Jr., MD, a senior investigator at the Gladstone Institutes, is the other co-senior author. Stanford graduate student Maria Armakola shares co-first authorship with Matthew Higgins, PhD, a postdoctoral scholar at Gladstone.

Most cases of ALS have no clear-cut cause. However, it has recently been shown that an RNA-binding protein called TDP-43 accumulates in clumps in the cytoplasm of spinal cord neurons in many people with the condition, and mutations in this protein have been found in some people with the ALS. Researchers li
'/>"/>

Contact: Krista Conger
kristac@stanford.edu
650-725-5371
Stanford University Medical Center
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. Models developed from the PLCO may help identify at-risk patients for adverse smoking outcomes
2. Drug shows promise in animal model of Alzheimers and Parkinsons with dementia
3. Mouse model exposes a new type of T cell to target melanoma
4. Modeling Good Research Practices guidelines for modeling in health care research available now
5. Genetically-engineered preclinical models predict pharmacodynamic response
6. Weizmann Institutes mathematical model may lead to safer chemotherapy
7. Modeling sepsis in newborns
8. A model for development
9. A CNIO team creates a unique mouse model for the study of aplastic anaemia
10. A new model for predicting recovery after spinal cord injury
11. TRPM7 protein key to breast cancer metastasis in animal models
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2013)... DiaperBuys.com is pleased to announce the winners of ... Olathe, Kansas, won the grand prize: a six-month supply ... a three-month supply of Cuties diapers and was awarded ... prize, a one-month supply, went to Chris Calderon of ... company’s Facebook page. Entrants uploaded their cutest baby photos ...
(Date:5/24/2013)... May 24, 2013 http://www.resource4thepeople.com/defectivedrugs/Zithromax-lawsuits.html ... the latest update involving allegations that the use ... (azithromycin) can allegedly cause potentially fatal irregular ... on May 17, 2013* that Health Canada has ... warning that Zithromax can cause abnormal changes in ...
(Date:5/24/2013)... 24, 2013 HCG EZ Drops has ... excited to announce it’s new weight loss initiative. “We are so ... offering our customers their money back if they don’t lose 21 ... HCG EZ Drops. “The HCG Diet consists of 21 days ... pounds in 21 days.” , The controversial, cutting-edge diet has been ...
(Date:5/24/2013)... 24, 2013 IMED Mobility, a premier provider of ... by Nashville recording artist Michelle Murray on Thursday, June 20th 2 ... “My Finish Line” music and movie tour, which shares the story ... crash on the track in 2000. Much of the film takes ... for the sport of INDYCAR racing despite suffering a crash that ...
(Date:5/24/2013)... Psoriasis treatment cream has been released online ... FDA registered company is now offering its natural solution ... Psoriasis infected skin. , Dermasis has launched its new ... soothing cream is designed to offer immediate relief to ... of red skin often caused by psoriasis outbreaks. This ...
Breaking Medicine News(10 mins):Health News:DiaperBuys.com Announces Photo Contest Winners 2Health News:2013 Alleged Zithromax Arrhythmia and Sudden Death Cases Update: Canadian Health Officials Issue Warning 2Health News:2013 Alleged Zithromax Arrhythmia and Sudden Death Cases Update: Canadian Health Officials Issue Warning 3Health News:2013 Alleged Zithromax Arrhythmia and Sudden Death Cases Update: Canadian Health Officials Issue Warning 4Health News:Local Mobility Dealer Hosts Nashville Recording Artist 2Health News:Dermasis Psoriasis Treatment Cream for Men and Women Released Online at HealthCareSupplementz.com 2
... Million Americans Have Parkinson,s Disease, Roughly ... ... 21 Accolade, a Texas-based home,healthcare and hospice provider, observes ... Parkinson,s disease.,Accolade,s innovative short-term program enables people living with the,disease ...
... proved more beneficial than individual grief counseling, study finds ... experience the unexpected death of a parent after a ... finding that has major implications for helping children deal ... "Often children who have lost a parent are given ...
... than 6 millimeters in diameter appear more likely to ... in the April issue of Archives of Dermatology, one ... diameter guidelines currently used by dermatologists to screen for ... method to screen for melanoma, according to background information ...
... Decisions on Bottom Line Return at 3rd Annual ... Pharmaceutical Market Research Summit, NEW ... the pharmaceutical analytics company Eularis, will be,delivering a presentation on ... Research and Decisions on Bottom Line Return., ...
... of West Nile Virus and Other Diseases, SACRAMENTO, ... in hand. Coinciding with the launch of mosquito season, ... to April 25,2008 West Nile Virus and Mosquito and ... a mosquito-borne disease that can result in,debilitating cases of ...
... suggests , , MONDAY, April 21 (HealthDay News) -- The ... disease than women appear during the adolescent years, according a ... , "This is not what we would have predicted," said ... the University of Minnesota Children,s Hospital, and lead author of ...
Cached Medicine News:Health News:April is National Parkinson's Disease Awareness Month 2Health News:April is National Parkinson's Disease Awareness Month 3Health News:Treating PTSD Helps Kids Deal With Loss 2Health News:Larger skin lesions appear more likely to be melanomas 2Health News:Eularis to Address Making the Right Research Decision for ROI 2Health News:State Legislature Declares April 21 to 25, 2008 West Nile Virus and Mosquito and Vector Control Awareness Week 2Health News:Heart Disease Risks Hit Boys in Teens 2
(Date:5/24/2013)... 24, 2013  Heska Corporation (NASDAQ: HSKA, "Heska" or the ... announced today that Dr. Robert Grieve , ... Jason Napolitano , executive vice president and chief financial ... which is being held May 30, 2013 in ... The Company,s presentation is scheduled to begin ...
(Date:5/24/2013)... May 24, 2013 China Biologic Products, Inc. ... fully integrated plasma-based biopharmaceutical company in China ... learned from a public announcement issued by Shanghai RAAS ... listed on Shenzhen Stock Exchange, that on May 21, ... ("Ms. Chan"), one of the shareholders of the Company, ...
(Date:5/24/2013)... CHESTERBROOK, Pa. , May 24, 2013  Auxilium ... that executive management will participate in the Deutsche Bank ... the Westin Boston Waterfront Hotel.  Mr. Adrian ... scheduled to present an overview of the Company and ... May 29, 2013.   (Logo: http://photos.prnewswire.com/prnh/20101202/MM10881LOGO ...
Breaking Medicine Technology:Heska Corporation To Present At The Second Annual Marcum LLP MicroCap Conference 2China Biologic Comments on the Proposed Shanghai RAAS Transaction 2China Biologic Comments on the Proposed Shanghai RAAS Transaction 3China Biologic Comments on the Proposed Shanghai RAAS Transaction 4Auxilium Pharmaceuticals, Inc. To Present At The Deutsche Bank Health Care Conference 2Auxilium Pharmaceuticals, Inc. To Present At The Deutsche Bank Health Care Conference 3Auxilium Pharmaceuticals, Inc. To Present At The Deutsche Bank Health Care Conference 4
... Campath May Lead to Overall Survival in Patients with Poor ... FRANCISCO, Dec. 9 Bayer HealthCare Pharmaceuticals Inc. today announced ... showed activity in high-risk chronic lymphocytic leukemia (CLL) patients who ... 50th Annual Meeting of the American Society of Hematology in ...
... 8 Millennium: The Takeda Oncology Company today ... of patients from the large, international Phase III ... with previously untreated multiple myeloma given VELCADE, melphalan ... efficacy in all patient sub-groups, including those with ...
Cached Medicine Technology:Three Studies Presented at the American Society of Hematology Annual Meeting Showed Response to Treatment with Campath(R) in Patients with High-Risk CLL 2Three Studies Presented at the American Society of Hematology Annual Meeting Showed Response to Treatment with Campath(R) in Patients with High-Risk CLL 3Three Studies Presented at the American Society of Hematology Annual Meeting Showed Response to Treatment with Campath(R) in Patients with High-Risk CLL 4Three Studies Presented at the American Society of Hematology Annual Meeting Showed Response to Treatment with Campath(R) in Patients with High-Risk CLL 5Three Studies Presented at the American Society of Hematology Annual Meeting Showed Response to Treatment with Campath(R) in Patients with High-Risk CLL 6Three Studies Presented at the American Society of Hematology Annual Meeting Showed Response to Treatment with Campath(R) in Patients with High-Risk CLL 7Three Studies Presented at the American Society of Hematology Annual Meeting Showed Response to Treatment with Campath(R) in Patients with High-Risk CLL 8Three Studies Presented at the American Society of Hematology Annual Meeting Showed Response to Treatment with Campath(R) in Patients with High-Risk CLL 9Three Studies Presented at the American Society of Hematology Annual Meeting Showed Response to Treatment with Campath(R) in Patients with High-Risk CLL 10Continued Overall Survival Advantage Reported From Pivotal Trial of VELCADE(R) (Bortezomib) for Injection Based Therapy in Patients With Previously Untreated Multiple Myeloma 2Continued Overall Survival Advantage Reported From Pivotal Trial of VELCADE(R) (Bortezomib) for Injection Based Therapy in Patients With Previously Untreated Multiple Myeloma 3Continued Overall Survival Advantage Reported From Pivotal Trial of VELCADE(R) (Bortezomib) for Injection Based Therapy in Patients With Previously Untreated Multiple Myeloma 4Continued Overall Survival Advantage Reported From Pivotal Trial of VELCADE(R) (Bortezomib) for Injection Based Therapy in Patients With Previously Untreated Multiple Myeloma 5Continued Overall Survival Advantage Reported From Pivotal Trial of VELCADE(R) (Bortezomib) for Injection Based Therapy in Patients With Previously Untreated Multiple Myeloma 6
... Basic ergonomic chairs with ... with lumbar support • Select ... and casters and glides. • ... the following environments: industry, education, ...
... concave seats and standard-sized backrests with ... seats, backrests, armrests, and casters and ... for the following environments: industry, education, ... care and office. • With tubular ...
... Durable ergonomic chairs with concave ... support • Select options like seats, ... • Choose the BE Series for ... environments including: industry, education, laboratory, clean ...
... Durable ergonomic chairs with concave seats ... • Select options like seats, backrests, ... Choose the BE Series for top ... including: industry, education, laboratory, clean room, ...
Medicine Products: