Navigation Links
Yeast model offers clues to possible drug targets for Lou Gehrig's disease, study shows
Date:10/28/2012

STANFORD, Calif. Amyotrophic lateral sclerosis, also called Lou Gehrig's disease, is a devastatingly cruel neurodegenerative disorder that robs sufferers of the ability to move, speak and, finally, breathe. Now researchers at the Stanford University School of Medicine and San Francisco's Gladstone Institutes have used baker's yeast a tiny, one-celled organism to identify a chink in the armor of the currently incurable disease that may eventually lead to new therapies for human patients.

"Even though yeast and humans are separated by a billion years of evolution, we were able to use the power of yeast genetics to identify an unexpected potential drug target for ALS," said Aaron Gitler, PhD, an associate professor of genetics at Stanford. "Many neurodegenerative disorders such as ALS, Parkinson's and Alzheimer's exhibit protein clumping or misfolding within the neurons that is thought to either cause or contribute to the conditions. We are trying to figure out why these proteins aggregate in neurons in the brain and spinal cord, and what happens when they do."

In 2008, Gitler received a New Innovator award from the National Institutes of Health to use yeast as a model for understanding human neurodegenerative diseases and as a way to identify new targets for drug development.

Gitler is the co-senior author of the research, which will be published online Oct. 28 in Nature Genetics. Robert Farese, Jr., MD, a senior investigator at the Gladstone Institutes, is the other co-senior author. Stanford graduate student Maria Armakola shares co-first authorship with Matthew Higgins, PhD, a postdoctoral scholar at Gladstone.

Most cases of ALS have no clear-cut cause. However, it has recently been shown that an RNA-binding protein called TDP-43 accumulates in clumps in the cytoplasm of spinal cord neurons in many people with the condition, and mutations in this protein have been found in some people with the ALS. Researchers li
'/>"/>

Contact: Krista Conger
kristac@stanford.edu
650-725-5371
Stanford University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Models developed from the PLCO may help identify at-risk patients for adverse smoking outcomes
2. Drug shows promise in animal model of Alzheimers and Parkinsons with dementia
3. Mouse model exposes a new type of T cell to target melanoma
4. Modeling Good Research Practices guidelines for modeling in health care research available now
5. Genetically-engineered preclinical models predict pharmacodynamic response
6. Weizmann Institutes mathematical model may lead to safer chemotherapy
7. Modeling sepsis in newborns
8. A model for development
9. A CNIO team creates a unique mouse model for the study of aplastic anaemia
10. A new model for predicting recovery after spinal cord injury
11. TRPM7 protein key to breast cancer metastasis in animal models
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... TORONTO, April 17, 2014 Giving patients adrenaline after they ... not increase their prospects of surviving long-term, according to ... vast number of patients who have a cardiac arrest ... treating cardiac arrest for decades," said Dr. Steve Lin, ... Michael,s. "Yet, despite advances in medical treatment, long-term survival ...
(Date:4/16/2014)... 15, 2014 The Translational Genomics Research Institute (TGen) ... Founders Dinner for their support of TGen,s research into ... March 28 in Scottsdale. , Catherine Ivy, Founder and ... TGen,s John S. McCain Leadership Award, named for U.S. ...
(Date:4/15/2014)... pre-diabetes in the United States have nearly doubled since 1988, ... Public Health, with obesity apparently to blame for the surge. ... has not hit all groups equally, with alarming increases in ... new research reported in the April 15, 2014 issue of ...
(Date:4/14/2014)... over the past decade, but targeting drugs to cancer ... major challenge. , Nanotechnology has unlocked new pathways ... or capsules, that can transport cargoes of small-molecule therapeutics ... These carriers are tiny, and it matters just how ...
(Date:4/14/2014)... IL A new study shows that moderate to severe obstructive ... cancer and death. , Results of the 20-year follow-up study show ... times more likely to die (hazard ratio = 4.2), nearly four ... times more likely to die from cancer (HR = 3.4), and ...
Breaking Medicine News(10 mins):Health News:Adrenaline does little to increase patient's survival after cardiac arrest 2Health News:TGen honors Catherine Ivy and Craig Jackson with Leadership; Collaborative Spirit awards 2Health News:Pre-diabetes and diabetes nearly double over the past 2 decades 2Health News:Nano shake-up 2Health News:Study links severe sleep apnea to increased risk of stroke, cancer and death 2
... Awareness of Lupus and ... Funds for Lupus Foundation of America, WASHINGTON, Sept. 13 ... Houston, Texas, two recent,college graduates, will end their 15 week ... 4,000 miles from Bellingham,Washington to Charleston, South Carolina. The ...
... Novelli as MDMA,s Director of Federal Affairs, ... (MDMA) is pleased to announce the appointment of,Thomas ... Affairs., (Photo: http://www.newscom.com/cgi-bin/prnh/20041004/MDMALOGO ), ... Senate Committee on Finance,for Senator Charles Grassley from ...
... explores industry trends and the utilization of ... 13 Visiprise, Inc., a leader in,manufacturing execution ... the company will host a series of podcast ... Titled "Operational,Efficiency in Medical Device Manufacturing," these free, ...
... SAN DIEGO, Sept. 13 NuVasive, Inc. (Nasdaq:,NUVA), ... for,minimally disruptive surgical treatments for the spine, announced ... and Kevin,O,Boyle, Executive Vice President and Chief Financial ... 5th Annual Growth,Conference at the St. Regis Hotel, ...
... China,Shenghuo Pharmaceutical Holdings, Inc. ("China Shenghuo," "the ... in the research, development, manufacture,and marketing of ... People,s Republic of China ("PRC"), today announced ... Chinese herbal skin care,products ("12Ways") on Sunday, ...
... Education Council raises awareness about prostate cancer ... and related health concerns, ... he,has prostate cancer -- the second-leading cause of cancer death in ... making prostate,cancer among men more prevalent than breast cancer among women. ...
Cached Medicine News:Health News:Bike Ride Across the U.S. to End Saturday at Folly Beach 2Health News:MDMA Names New Director of Federal Affairs 2Health News:Visiprise Launches Podcast Series with AMR to Support Medical Device Manufacturers 2Health News:NuVasive to Present at ThinkEquity Partners 5th Annual Growth Conference 2Health News:NuVasive to Present at ThinkEquity Partners 5th Annual Growth Conference 3Health News:China Shenghuo Pharmaceutical Holdings, Inc. Begins Full-Scale Launch of 12Ways(R) Chinese Herbal Skin Care Product Line 2Health News:China Shenghuo Pharmaceutical Holdings, Inc. Begins Full-Scale Launch of 12Ways(R) Chinese Herbal Skin Care Product Line 3Health News:China Shenghuo Pharmaceutical Holdings, Inc. Begins Full-Scale Launch of 12Ways(R) Chinese Herbal Skin Care Product Line 4Health News:Prostate Cancer Awareness Week to Screen Thousands 2
(Date:1/15/2014)... LOUISVILLE, Ky. , Jan. 15, 2014  Manufacturers, ... technologies must be able to protect their most ... (Logo: http://photos.prnewswire.com/prnh/20130716/CL46586LOGO ) Because ... Industry, it steadfastly remains one of the most ...
(Date:1/15/2014)... , Jan. 15, 2014 MultiCell Technologies, Inc. (OTC ... U.S. provisional patent application concerning composition of matter, biological ... targeted tumor cell death.  This patent ... double stranded RNA molecules (VSRNAs) which interfere with the ...
(Date:1/15/2014)... 2014  According to Millennium Research Group (MRG), the ... the United States and European ... expand moderately through 2022, with embolization particles representing ... interest in drug-eluting beads (DEBs) and radioembolization spheres ...
Breaking Medicine Technology:Intellectual Property Insurance for Medical-related Products and Services 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 3US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 2US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 3
... YORK, July 4, 2011 ... market research report is available ... Global Pharmaceutical Industry Outlook ... Trends and Opportunities, Buyer Spend ...
... 2011 Simulated Environment Concepts (SMEV.PK), the manufacturer ... equipment, announced today that the Company has entered into what ... Management expects that much of the difficult items ... believes it is much more knowledgeable today about the auditing ...
Cached Medicine Technology:Global Pharmaceutical Industry Outlook Survey 2011-2012: Industry Dynamics, Market Trends and Opportunities, Buyer Spend and Procurement Strategies 2Global Pharmaceutical Industry Outlook Survey 2011-2012: Industry Dynamics, Market Trends and Opportunities, Buyer Spend and Procurement Strategies 3Global Pharmaceutical Industry Outlook Survey 2011-2012: Industry Dynamics, Market Trends and Opportunities, Buyer Spend and Procurement Strategies 4Global Pharmaceutical Industry Outlook Survey 2011-2012: Industry Dynamics, Market Trends and Opportunities, Buyer Spend and Procurement Strategies 5Global Pharmaceutical Industry Outlook Survey 2011-2012: Industry Dynamics, Market Trends and Opportunities, Buyer Spend and Procurement Strategies 6Global Pharmaceutical Industry Outlook Survey 2011-2012: Industry Dynamics, Market Trends and Opportunities, Buyer Spend and Procurement Strategies 7Global Pharmaceutical Industry Outlook Survey 2011-2012: Industry Dynamics, Market Trends and Opportunities, Buyer Spend and Procurement Strategies 8Global Pharmaceutical Industry Outlook Survey 2011-2012: Industry Dynamics, Market Trends and Opportunities, Buyer Spend and Procurement Strategies 9Global Pharmaceutical Industry Outlook Survey 2011-2012: Industry Dynamics, Market Trends and Opportunities, Buyer Spend and Procurement Strategies 10Global Pharmaceutical Industry Outlook Survey 2011-2012: Industry Dynamics, Market Trends and Opportunities, Buyer Spend and Procurement Strategies 11Simulated Environment Concepts Nears Audit Completion 2Simulated Environment Concepts Nears Audit Completion 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: