Navigation Links
Yale test detects early stage ovarian cancer with 99 percent accuracy
Date:2/12/2008

Researchers at Yale School of Medicine have developed a blood test with enough sensitivity and specificity to detect early stage ovarian cancer with 99 percent accuracy.

Results of this new study are published in the February 15 issue of the journal Clinical Cancer Research. The results build on work done by the same Yale group in 2005 showing 95 percent effectiveness of a blood test using four proteins.

The ability to recognize almost 100 percent of new tumors will have a major impact on the high death rates of this cancer, said Mor. We hope this test will become the standard of care for women having routine examinations.

Epithelial ovarian cancer is the leading cause of gynecologic cancer deaths in the United States and three times more lethal than breast cancer. It is usually not diagnosed until its advanced stages and has come to be known as the silent killer.

This new phase II clinical trial led by Gil Mor, M.D., associate professor in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale, included 500 patients; 350 healthy controls and 150 ovarian cancer patients. Mor and colleagues validated the previous research and used a new platform called multiplex technology to simplify the test into one single reaction using very small amounts of serum from the blood. The new platform uses six protein biomarkers instead of four, increasing the specificity of the test from 95 to 99.4 percent. The team looked for the presence of specific proteins and quantified the concentration of those proteins in the blood.

The Early Detection Research Network (EDRN) of the National Cancer Institute (NCI) independently evaluated the results of the test.

This is the most sensitive and specific test currently available, said Mor. Previous tests recognized 15 to 20 percent of new tumors. Proteins from the tumors were the only biomarkers used to test for ovarian cancer. That is okay when you have big masses of tumors, but it is not applicable in very early phases of the tumor. Testing the proteins produced by the body in response to the presence of the tumor as well as the proteins the tumors produce, helped us to create a unique picture that can detect early ovarian cancer.

Mor and colleagues have begun a phase III evaluation in a multi-center clinical trial. In collaboration with EDRN/NCI and Laboratories Corporation of America (LabCorp), they are testing close to 2,000 patients.

The test is available at Yale through the Discovery to Cure program. Yale has licensed the test to three companies: Lab Corp in the United States, Teva in Israel and SurExam in China.


'/>"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
Source:Eurekalert  

Related medicine news :

1. Test Detects Sensitivity to HIV Drug
2. McMaster test detects the most prevalent respiratory viruses
3. CT colonography detects wide-range of extracolonic abnormalities in elderly patients
4. Blood protein detects lung cancer, even at earliest stage
5. New technique detects specific chromosomal damage, may indicate lung cancer risk
6. New Survey Suggests Confusion, Lack of Awareness About Heart Failure Could Be Preventing Critical Early Detection and Treatment
7. JCI online early table of contents: Feb. 7, 2008
8. New study suggests link between environmental toxins and early onset puberty in girls
9. A Reminder to Parents: Early Dental Visits Essential to Childrens Health
10. Rheumatoid arthritis sends many into early retirement
11. Early detection critical in treating pediatric thyroid cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Yale test detects early stage ovarian cancer with 99 percent accuracy
(Date:2/11/2016)... NEW ORLEANS (PRWEB) , ... February 11, 2016 , ... ... : Achieving Satisfaction through a Well Managed Mind” (published by Balboa Press) teaches readers ... unique way of being through profound love, author Janice McDermott, M.Ed., LCSW, offers an ...
(Date:2/11/2016)... ... February 11, 2016 , ... Student-doctors from Western University of ... Program Tuesday, February 9, taking one of the final steps in their medical ... positions across the country. Of the 103 student-doctors who comprise the College of ...
(Date:2/11/2016)... ... 2016 , ... Florida Hospital presents Heart Health Awareness night on Sunday February ... the Amalie Arena. The puck drops at 6:00pm, but fans will have the opportunity ... to the game. The MEGA Heart will be located on Ford Thunder Alley and ...
(Date:2/11/2016)... Alexandria, Va. (PRWEB) , ... February 11, 2016 , ... ... for the DoD Military Health System but would shift more of the cost burden ... described the TRICARE-reform plan laid out in the defense budget as including limited quantifiable ...
(Date:2/11/2016)... ... February 11, 2016 , ... Pediatric cardiovascular surgeons, cardiologists ... by making data on heart procedures public and easily understandable for families and ... Reporting of Pediatric and Congenital Heart Disease Outcomes will bring hundreds of pediatric ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... Feb. 11, 2016  Delcath Systems, Inc. (NASDAQ: ... device company focused on oncology with an emphasis ... cancers, announces the engagement of Lars E. ... Medical Consultant. Dr. Birgerson will provide strategic medical ... operations team to help ensure timely facilitation of ...
(Date:2/11/2016)... 11, 2016 SI-BONE, Inc., a medical ... iFuse Implant System, a minimally invasive surgical (MIS) ... the sacroiliac (SI) joint, announced the publication of ... MIS SI joint fusion for patients suffering from ... or SI joint disruption.  In the first article, ...
(Date:2/11/2016)... CARLSBAD, Calif. , Feb.11, 2016  Ionis Pharmaceuticals, Inc. ... a live webcast on Thursday, February 25 at 11:30 a.m. ... on pipeline and business progress. www.ionispharma.com . ... at the same address. --> www.ionispharma.com . A ... the same address. --> Interested parties may listen ...
Breaking Medicine Technology: