Navigation Links
Yale team discovers how stress and depression can shrink the brain
Date:8/12/2012

Major depression or chronic stress can cause the loss of brain volume, a condition that contributes to both emotional and cognitive impairment. Now a team of researchers led by Yale scientists has discovered one reason why this occurs a single genetic switch that triggers loss of brain connections in humans and depression in animal models.

The findings, reported in the Aug. 12 issue of the journal Nature Medicine, show that the genetic switch known as a transcription factor represses the expression of several genes that are necessary for the formation of synaptic connections between brain cells, which in turn could contribute to loss of brain mass in the prefrontal cortex.

"We wanted to test the idea that stress causes a loss of brain synapses in humans," said senior author Ronald Duman, the Elizabeth Mears and House Jameson Professor of Psychiatry and professor of neurobiology and of pharmacology. "We show that circuits normally involved in emotion, as well as cognition, are disrupted when this single transcription factor is activated."

The research team analyzed tissue of depressed and non-depressed patients donated from a brain bank and looked for different patterns of gene activation. The brains of patients who had been depressed exhibited lower levels of expression in genes that are required for the function and structure of brain synapses. Lead author and postdoctoral researcher H.J. Kang discovered that at least five of these genes could be regulated by a single transcription factor called GATA1. When the transcription factor was activated, rodents exhibited depressive-like symptoms, suggesting GATA1 plays a role not only in the loss of connections between neurons but also in symptoms of depression.

Duman theorizes that genetic variations in GATA1 may one day help identify people at high risk for major depression or sensitivity to stress.

"We hope that by enhancing synaptic connections, either with novel medications or behavioral therapy, we can develop more effective antidepressant therapies," Duman said.


'/>"/>
Contact: Bill Hathaway
william.hathaway@yale.edu
203-432-1322
Yale University
Source:Eurekalert  

Related medicine news :

1. IBN discovers human neural stem cells with tumor targeting ability
2. Rutgers team discovers novel approach to stimulate immune cells
3. UZH research team discovers the origins of key immune cells
4. Positive stress helps protect eye from glaucoma
5. Scientists identify major source of cells defense against oxidative stress
6. Stress contributes to cognitive declines in women with breast cancer, researcher says
7. Stress about wifes breast cancer can harm a mans health
8. Gatekeeper of brain steroid signals boosts emotional resilience to stress
9. Stress May Be Tougher on Womens Hearts Than Mens: Study
10. Email vacations decrease stress, increase concentration, researchers say
11. Email Vacations Boost Job Productivity, Lower Stress: Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Yale team discovers how stress and depression can shrink the brain
(Date:5/4/2016)... ... May 04, 2016 , ... World Patent Marketing , ... a sports invention that aids in the improvement of the grip and swing ... $9 billion," says Scott Cooper, CEO and Creative Director of World Patent Marketing. ...
(Date:5/4/2016)... ... 04, 2016 , ... Trinity Health today launched its inaugural ... aimed at improving care and reducing readmission rates for patients who are dually ... Health is to drive innovation that transforms our ministry and our industry to ...
(Date:5/4/2016)... ... 2016 , ... NCPDP announced today highlights from ... Frank Luntz, sharing a dynamic, bi-partisan environmental scan of healthcare-related campaign issues. Today’s ... model solution to help stem the tide of the opioid epidemic and put ...
(Date:5/4/2016)... CA (PRWEB) , ... May 04, 2016 , ... Level ... -- announced her verbal commitment to the University of Arizona for the fall of ... announced her decision last month. Brovedani’s commitment to the GymCats came from her connection ...
(Date:5/4/2016)... ... May 04, 2016 , ... IsoComforter, Inc., ... introduction of the innovative newly improved Iso-Hip Wrap. The newly designed hip ... design enhances comfort and enables the patient to enjoy the benefits of cold ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... , May 4, 2016 According ... Development, Growth and Demand Forecast to 2022 - Industry Insights ... (Hospital, Diagnostic Center and Others)" by P&S Market Research, the ... million in 2015, and it is expected to grow at ... the high slice type segment is expected to witness the ...
(Date:5/4/2016)... 4, 2016 Research ... "Global Acute Ischemic Stroke Market and Competitive ... offering.       (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ... Ischemic Stroke Market and Competitive Landscape Highlights ... Stroke pipeline products, Acute Ischemic Stroke epidemiology, ...
(Date:5/3/2016)... KANSAS CITY, Mo. , May 3, 2016 ... of Kansas Medical Center,s Institute for Advancing Medical ... develop and commercialize new drugs, diagnostics and medical ... organizations provides BioNovus Innovations with rights to license, ... "This partnership ...
Breaking Medicine Technology: