Navigation Links
Yale researchers use genetic code to engineer a living protein
Date:8/25/2011

Yale University researchers have successfully re-engineered the protein-making machinery in bacteria, a technical tour de force that promises to revolutionize the study and treatment of a variety of diseases.

"Essentially, we have expanded the genetic code of E. coli, which allows us synthesize special forms of proteins that can mimic natural or disease states," said Jesse Rinehart of the Department of Cellular and Molecular Physiology and co-corresponding author of the research published in the August 26 issue of the journal Science.

Since the structure of DNA was revealed in the 1950s, scientists have been working hard to understand the nature of the genetic code. Decades of research and recent advances in the field of synthetic biology have given researchers the tools to modify the natural genetic code within organisms and even rewrite the universal recipe for life.

"What we have done is taken synthetic biology and turned it around to give us real biology that has been synthesized," Rinehart explained.

The Yale team under the direction of Dieter Sll, Sterling Professor of Molecular Biophysics and Biochemistry, professor of chemistry and corresponding author of the paper developed a new way to influence the behavior of proteins, which carry out almost all of life's functions. Instead of creating something new in nature, the researchers essentially induced phosphorylation, a fundamental process that occurs in all forms of life and can dramatically change a protein's function. The rules for protein phosphorylation are not directly coded in the DNA but instead occur after the protein is made. The Yale researchers fundamentally rewrote these rules by expanding the E. coli genetic code to include phosphoserine, and for the first time directed protein phosphorylation via DNA.

This new technology now enables the production of human proteins with their naturally occurring phosphorylation sites, a state crucial to
'/>"/>

Contact: Bill Hathaway
william.hathaway@yale.edu
203-432-1322
Yale University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers developing new test to measure risk for birth defects and neuro-developmental disorders
2. Breast-Feeding Wont Prevent Kids Eczema, Researchers Say
3. Government subsidies to the US film industry promote youth smoking, argue researchers
4. Researchers Say Theyve Found Common Cause of All Types of ALS
5. UCSD researchers alarmed at rise in hookah use among California youth
6. Researchers building new sensor that could stop falls by elderly, before they happen
7. AIDS researchers isolate new potent and broadly effective antibodies against HIV
8. Pitt cancer researchers find key oncoprotein in Merkel cell carcinoma
9. Researchers create new experimental vaccine against chikungunya virus
10. USF researchers get $2.6 million NIH grant to investigate new post-stroke therapy
11. Childrens National collaborates with NIH researchers to identify gene variant in Proteus syndrome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2015)... Columbus, Ohio (PRWEB) , ... August 28, 2015 ... ... Saturday’s Imagine No Malaria Day at the Zoo to celebrate children helping children, ... people and their congregations throughout West Ohio have contributed to the United Methodist ...
(Date:8/28/2015)... ... August 28, 2015 , ... With the goal of furthering music education programs ... to the Adams County Fairgrounds in Mendon, IL on May 30th, 2015. Backed once ... music education in the underfunded school districts of Mendon and its neighboring town of ...
(Date:8/28/2015)... ... 28, 2015 , ... As reported by Medical Daily on August 22 ... results that last for two years, the longest of any cellulite reduction system currently ... for a long-lasting, effective solution for their cellulite, according to Dr. Robert Weiss, director ...
(Date:8/28/2015)... ... August 28, 2015 , ... ... those who might personally be struggling with chemical dependency, may be able to ... Drug Rehabilitation, a results-driven holistic treatment center for addiction located in Western Michigan. ...
(Date:8/28/2015)... ... August 28, 2015 , ... Altima Technologies, Inc., the maker ... data center assets and audio-video devices, recently released Visio Stencils for the following ... ProLiant Gen9, EMC VNX Series , Super Micro Computer SuperStorage, Hitachi Data Systems ...
Breaking Medicine News(10 mins):Health News:Saturday’s United Methodist Event at Columbus Zoo Celebrates Imagine No Malaria 2Health News:Saturday’s United Methodist Event at Columbus Zoo Celebrates Imagine No Malaria 3Health News:Best Drug Rehabilitation Interviews Country-Rock Duo Highway Run at the 2015 "Music With A Mission" Benefit Concert 2Health News:Maryland Dermatologists Discuss Non-Invasive Cellulite Reduction System Cellfina Receiving 2-Year FDA Clearance 2Health News:Maryland Dermatologists Discuss Non-Invasive Cellulite Reduction System Cellfina Receiving 2-Year FDA Clearance 3Health News:Best Drug Rehabilitation Releases New Video Outlining Patients' Personal Recovery Stories 2Health News:Best Drug Rehabilitation Releases New Video Outlining Patients' Personal Recovery Stories 3Health News:Altima Updates NetZoom™ Visio® Stencil Library for Cisco, HP, and EMC Devices 2Health News:Altima Updates NetZoom™ Visio® Stencil Library for Cisco, HP, and EMC Devices 3
... of Medicine (BUSM) and Public Health along with ... test scores not affected by intrauterine exposure to ... children who had no evidence of fetal alcohol ... math reasoning and spelling even after controlling for ...
... , FRIDAY, March 2 (HealthDay News) -- Approximately ... 50 and 75 who should be screened for colorectal ... for Gastrointestinal Endoscopy. As National Colorectal Cancer Awareness ... about the benefits of a colonoscopy exam to screen ...
... HealthDay Reporter , FRIDAY, March 2 (HealthDay News) -- ... demands of their own biology, women are more likely than ... see insomnia much more frequently in women, probably at least ... an assistant professor of neurology at the University of Texas ...
... matter. With this knowledge, University of Georgia researchers developed ... should be located. The results of their work could ... who dial 911 each year, according to the Federal ... critical time window [of 8 minutes], we can maximize ...
... of chains, which slowly break over time due to the ... squeezed, the pressure breaks chemical bonds and produces free radicals: ... are responsible for aging, DNA damage and cancer in the ... turned to squeezed polymers and free radicals in a search ...
... News) -- Researchers report they have developed a blood ... likely to experience the most severe symptoms of the disease. ... can suffer intense pain, internal organ damage and shortened ... to have the disease, which is caused by a genetic ...
Cached Medicine News:Health News:Study finds intrauterine exposure to drugs does not affect academic achievement test scores 2Health News:Too Many Americans Skipping Colon Cancer Screening 2Health News:For Sleep Struggles, Women Urged to Alter Routines 2Health News:For Sleep Struggles, Women Urged to Alter Routines 3Health News:For Sleep Struggles, Women Urged to Alter Routines 4Health News:GIS siting of emergency vehicles improves response time 2Health News:Energy squeeze 2Health News:Energy squeeze 3Health News:Sickle Cell Blood Test Might Predict Severity of Disease 2
(Date:8/27/2015)... FRANKLIN, Mass. , Aug. 27, 2015 /PRNewswire/ ... in the KSSTA Knee Journal, compared the Arthrosurface ... "inlay" Arthroplasty design, versus an "onlay" design implant ... showed similar improvements in function and pain scores, ... showed progression of osteoarthritis (OA). However, 53% of ...
(Date:8/27/2015)... According to a new market research report ... Standing, Bariatric ), Material (Nylon, Padded, Canvas), Usage Type (Disposable, Reusable), ... MarketsandMarkets, the Medical Lifting Sling Market is poised to reach USD ... a CAGR of 11.4 % from 2015 to 2020. ... data T ables and 65 F ...
(Date:8/27/2015)... , Aug. 27, 2015   Proxsys ... Provider (IOPP™) is expanding its population health ... medication-focused transition of care program for hospitals ... Management," provides hospitals with technology systems and ... measures that have been mandated by Center ...
Breaking Medicine Technology:Study Demonstrates Dramatic Reduction in Progression of Osteoarthritis with the Arthrosurface "Inlay" Patellofemoral Implant Design Compared to Traditional "Onlay" Implant 2Study Demonstrates Dramatic Reduction in Progression of Osteoarthritis with the Arthrosurface "Inlay" Patellofemoral Implant Design Compared to Traditional "Onlay" Implant 3Medical Lifting Sling Market Worth USD 706.0 Million by 2020 2Medical Lifting Sling Market Worth USD 706.0 Million by 2020 3Medical Lifting Sling Market Worth USD 706.0 Million by 2020 4Rx Care Management by Proxsys Rx - Transition of Care Technology Helps Prevent Hospital Medication Errors 2
... Ontario, Dec. 12, 2011 Valeant Pharmaceuticals International, Inc. (NYSE: ... the Federal Trade Commission (FTC) voted unanimously to approve the ... dermatology unit of Sanofi (EURONEXT: SAN and NYSE: ... division of Janssen Pharmaceuticals, Inc. As a ...
... PharMEDium announced the first generation solution ... Operating Room (O.R.).  PharMEDium has developed the ... "Our certiMED™ system is designed to be ... Ready-to-Use O.R. syringe medications by providing a visual and ...
Cached Medicine Technology:Valeant Pharmaceuticals Receives Approval From FTC in Connection With Acquisition of Ortho Dermatologics and Dermik 2PharMEDium Adds O.R. Medication Verification System 2
... (5-Androstene-3-0L-17-one,Androstenolone, Dehydroisoandrosterone,Transdehydroandrosterone, DHEA) is a ... mostly in its,sulfate form (DHEA-S). ... based on the competition principle ... amount of DHEA-S present in ...
Beta-2 Microglobulin EIA Lipid / Protein Quantification 025-BC-1061...
Myoglobin EIA Lipid / Protein Quantification, Cardiovascular 024-IDC-13 Muscle Disease...
Human Growth Hormone EIA Endocrine Function 025-BC-1033...
Medicine Products: