Navigation Links
Yale researchers see decline in hospitalizations for serious heart infection

Hospitalizations for endocarditis, a deadly heart infection that disproportionately affects older heart patients, have declined in recent years despite recommendations for limited use of antibiotics to prevent the illness. These findings were recently published by Yale School of Medicine researchers in the Journal of the American College of Cardiology.

Endocarditis is the most serious infection of the cardiovascular system, and the risk increases with surgical procedures. Past studies showed a marked increase in endocarditis hospitalization rates during the 1990s. As a preventative measure, many clinicians routinely prescribed antibiotics before dental procedures, and gastrointestinal and other types of surgeries.

While endocarditis risk factors, such as rheumatic heart disease, have declined recently, the risk has increased for those with cardiac pacemakers and prosthetic valves. In addition, the American Heart Association narrowed the use of antibiotics for endocarditis to only a subgroup of patients undergoing dental procedures.

In light of these changes, the Yale research team, led by first author Behnood Bikdeli, M.D., postdoctoral associate in cardiovascular medicine at the Yale Center for Outcomes Research and Evaluation, assessed the annual rates of endocarditis hospitalization and the related outcomes among 262,658 Medicare patients aged 65 and older from 1999 through 2010.

The study showed an increase in endocarditis hospitalizations from 1999 to 2005. However from 2006 to 2010, the team saw no increase, but instead noticed a decline. "We were surprised to see reduced rates of endocarditis hospitalizations during this time period," said Bikdeli who is also an internal medicine resident at Yale. "This downward trend was consistent in all major study subgroups, but certain subgroups, including black participants, had higher hospitalization rates and worse outcomes in the study period."

Bikdeli said this racial disparity in outcomes, as well as reasons for the overall decline in hospitalizations, should be investigated further. He added, "We would ideally like to see comparative effectiveness studies, such as randomized trials, to test antibiotics' efficacy, but due to the expense and the minimal potential effects of antibiotics, such a study would be unlikely in the near future. Therefore, surveillance investigations such as ours are particularly important to monitor the disease and outcomes."

"Clinicians should consider the risks and benefits of antibiotic-use on a case-by-case basis and should share the information with their patients for appropriate decision making," Bikdeli concluded.


Contact: Karen N. Peart
Yale University

Related medicine news :

1. Researchers identify novel biomarker for diabetes risk
2. Tufts researchers identify how Yersinia spreads within infected organs
3. Approved cancer drug potentially could help treat diabetes, Stanford researchers find
4. Mount Sinai Researchers Show Stem Cells Are Wired for Cooperation, Down to the DNA
5. Virginia Tech Carilion researchers find surprising relationships in brain signaling
6. Researchers to identify genetic biomarkers for aggressive breast cancer
7. Researchers link obesity and the bodys production of fructose
8. Researchers find whats missing in teen health programs
9. UCLA researchers describe new form of irritable bowel syndrome
10. Researchers study survival in African American versus Caucasian lung cancer patients
11. Researchers develop specific tests to identify cancer biomarkers in dermatomyositis
Post Your Comments:
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary of ... award to iHire in recognition of their exemplary accomplishments in worksite health promotion. , ... Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was ...
(Date:6/24/2016)... Marne, Michigan (PRWEB) , ... June 24, 2016 , ... ... To deal with these feelings, many turn to unhealthy avenues, such as drug or ... Center of Marne, Michigan, has released tools for healthy coping following a traumatic event. ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary ... Dallas that it will receive two significant new grants to support its work ... marked its 25th anniversary by recognizing patients, medical professionals and scientists for their ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Comfort Keepers® of ... Cancer Society and the Road To Recovery® program to drive cancer patients to and ... other adults to ensure the highest quality of life and ongoing independence. Getting ...
(Date:6/24/2016)... ... 2016 , ... EB Medicine presented its first-ever “Issue of ... in Ponte Vedra Beach, FL. The awards honor the outstanding work of leading ... and Pediatric Emergency Medicine Practice. , “With this award, we recognize the efforts ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Belgium , June 24, 2016 ... the appointment of Dr. Edward Futcher ... Non-Executive Director, effective June 23, 2016.Dr. Futcher was ... Nominations and Governance Committees.  As a non-executive member ... independent expertise and strategic counsel to VolitionRx in ...
(Date:6/23/2016)... Research and Markets has announced the ... to 2022" report to their offering. ... patients with kidney failure, it replaces the function of kidneys ... blood and thus the treatment helps to keep the patient ... Increasing number of ESRD patients & substantial ...
(Date:6/23/2016)...  In a startling report released today, National Safety Council ... a comprehensive, proven plan to eliminate prescription opioid overdoses. ... states are tackling the worst drug crisis in recorded U.S. history, ... Kentucky , New Mexico , ... the 28 failing states, three – Michigan , ...
Breaking Medicine Technology: