Clinical significance of TILs subtypes in non-small cell lung cancer.(#8082)
Authors: Kurt A. Schalper, Jason Brown, Joseph Francis McLaughlin, Roy S. Herbst, David L. Rimm; Department of Pathology, Yale School of Medicine, New Haven, CT; Department of Medical Oncology, Yale University, New Haven, CT; Yale Cancer Center, New Haven, CT; Department of Pathology, Yale University School of Medicine, New Haven, CT
Tumor infiltrating lymphocytes (TILs) are associated with better outcome in diverse neoplasms including nonsmall cell lung cancer (NSCLC). TILs are usually determined using subjective semi-quantitative methods. Studies suggest that TILs subtypes have independent roles and their contribution to prognosis remains unknown. Here, we measured TILs subtypes in NSCLC using objective methods and determined their relationship with clinico-pathologic characteristics and survival.
Increased CD3 and CD8 positive TILs are independent prognostic factors in NSCLC. Despite the positive relationship between TILs subtypes, only CD8 and CD20 show association with adenocarcinoma histology. Objective measurement of TILs subpopulations could be useful to predict response or monitor the off-target effect of anti-cancer immunostimulatory therapies.
Keywords: NSCLC; tumor infiltrating lymphocytes (TILs)
Effect of pre-existing mental health comorbidities (MHC) on stage and timeliness of care of solid tumors in Veterans Affairs Connecticut Healthcare System (VACHS).(#6542)
Authors: Roxanne Jimmy Wadia, Xiaopan Yao, Yanhong Deng, Jia Li, Steve Maron, Donna Connery, Handan Gunduz-Bruce, Michal G. Rose; Yale-New Haven Hospital, New Haven, CT; Yale Center for Analytical Sciences, New Haven, CT; Yale School of Medicine, New Haven, CT; VA Connecticut Healthcare System, West Haven, CT; VA Administration Connecticut, West Haven, CT
Axis I MHC affects approximat
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