Keywords: cervical cancer; screening; women's health; cancer disparities; prevention; public health
A Phase 2 Trial of Prostate Specific Membrane Antigen Antibody Drug Conjugate (PSMA ADC) in Taxane-Refractory Metastatic Castration-Resistant Prostate Cancer (mCRPC) (#5023)
Authors: Daniel Peter Petrylak, David C. Smith, Leonard Joseph Appleman, Mark T. Fleming, Arif Hussain, Robert Dreicer, A. Oliver Sartor, Neal D. Shore, Nicholas J. Vogelzang, Hagop Youssoufian, Vincent A. DiPippo, Nancy Stambler, Kathleen Huang, Robert Joseph Israel; Yale University Medical Center, New Haven, CT; University of Michigan Comprehensive Cancer Center, Ann Arbor, MI; University of Pittsburgh Medical Center, Pittsburgh, PA; US Oncology Research; Virginia Oncology Associates, Hampton, VA; University of Maryland Cancer Center, Baltimore, MD; Cleveland Clinic, Cleveland, OH; Tulane University, New Orleans, LA; Carolina Urologic Research Center, Atlantic Urology Clinics, Myrtle Beach, SC; Comprehensive Cancer Centers of Nevada, Las Vegas, NV; Progenics Pharmaceuticals, Inc., Tarrytown, NY
PSMA expression on prostate cancer cells provides a rationale for ADC therapy. PSMA is a clinically validated target. PSMA ADC is a fully human antibody to PSMA linked to the microtubule disrupting agent MMAE. It induces cell cycle arrest and apoptosis specifically in PSMA-positive cells. We have completed enrollment in a multicenter phase 2 trial of PSMA ADC in mCRPC pts progressing after taxane and antiandrogen.
PSMA ADC at 2.3 mg/kg was active and well tolerated in heavily pr
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