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Yale Cancer Center's tip sheet for the 50th Annual Meeting of ASCO May 30 - June 3, 2014
Date:5/22/2014

usual care group that received a brochure about lifestyle changes. After six months, women in the weight loss counseling group experienced an approximate 30% decrease in C-reactive protein (CRP) levels compared with a minimal decrease in women randomized to the usual care group. CRP is a marker of chronic inflammation and higher CRP levels have been associated with a higher risk of breast cancer mortality. A dose-response effect was found in women randomized to weight loss counseling in that women who lost at least 5% body weight experienced an approximate 22% decrease in insulin, 38% decrease in leptin, and 55% decrease in CRP, compared to significantly less biomarker improvement in women randomized to weight loss who lost less than 5% body weight.

Effect of exercise on weight, body fat, and serum inflammatory biomarkers in breast cancer survivors with aromatase inhibitor arthralgias (joint pain): The hormones and physical exercise (HOPE) study. (#9356)

Authors: Melinda Irwin, PhD, MPH; Brenda Cartmel, PhD; Cary Gross, MD; Fangyong Li, MPH, MS; Xiaopan Yao; Martha Fiellin, MPH; Elizabeth Ercolano, PhD; Maura Harrigan, MS, RD, CSO; Yang Zhou, MPH; Tara Sanft, MD; Kathryn Schmitz, PhD; Dawn Hershman, MD; Jennifer Ligibel, MD

Yale University, New Haven, CT; University of Pennsylvania, Philadelphia, PA; Columbia University, New York, New York; Dana Farber Cancer Institute, Boston, MA.

The HOPE study looked at the effect of exercise on body weight, body fat, and inflammatory biomarkers in 121 women with joint pain from taking aromatase inhibitors (AI) as adjuvant therapy. Participants were randomized into two groups those who participated in twice-weekly strength training and 2.5 hr/wk of moderate-intensive aerobic exercise and those who did no exercise (control group). After 12 months, the study found that the exercise group experienced an approximate 3% weight and body fat loss, and 6% decrease in CRP levels compared to increases
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Contact: Vicky Agnew
vicky.agnew@yale.edu
203-785-7001
Yale University
Source:Eurekalert

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